Effect of human recombinant vascular endothelial growth factor165on progression of atherosclerotic plaque

Abstract

Recombinant human VEGF increases the rate and degree of atherosclerotic plaque formation in the thoracic aorta in a cholesterol-fed rabbit model.

Serum bFGF levels are reduced in Japanese overweight men and restored by a 6-month exercise education

“…24 Another potential complication is the administration of angiogenic cytokines may promote the neointimal thickening and accelerate atherosclerosis by angiogenic stimuli on vasa vasorum of the artery wall. [25][26][27][28] So far, the clinical trials refute the idea that angiogenesis therapy stimulates tumor growth; however, animal studies have demonstrated that VEGF significantly enhances intimal thickening. [25][26][27][28] Since obesity is one of the major risk factors for atherosclerosis and coronary artery disease, the angiogenic status in overweight subjects without diabetes, hypertension, hyperlipidemia, and ischemic heart disease was evaluated in this investigation.…”

“…Indeed, in animal studies, there are still controversies whether it reduces intimal thickening by accelerating re-endothelialization 34 or enhances intimal thickening. [25][26][27][28] In preadipocytes in culture, bFGF stimulates the replication and inhibits their differentiation 10 and the expression of bFGF decreases during adipocyte differentiation 11 . In fully matured adipocytes, the addition of a high concentration of bFGF into culture media induces the reversal of adipocyte differentiation 12 and marked suppression of activity of GPDH 13 .…”

Critical role of the NADPH oxidase subunit p47phox on vascular TLR expression and neointimal lesion formation in high-fat diet-induced obesity

“…21 In contrast, treatment with VEGF stimulates plaque angiogenesis and promotes lesion progression both in ApoE À/À mice and in cholesterol-fed rabbit models. 43 There is a notable dearth of knowledge about the signaling processes that link ROS, angiogenesis and neointimal lesion formation. For instance, overexpression of the NADPH oxidase subunit, p22 phox has been shown to increase HIF-1a, VEGF expression and intralesional angiogenesis and to promote experimental atheroma progression.…”

Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo

“…26,27 A possible link between increased plasma levels of VEGF and the development of cardiovascular disease is discussed after two reports showed that administration of VEGF in mice and rabbits induced the progression of atherosclerotic plaques. 28,29 It should be mentioned, however, that the impact of adipose tissue VEGF to the serum VEGF level is still controversially discussed. Here we show that the inflammatory mediators IL-6 and OSM upregulate the expression of VEGF in human and murine adipose tissue and Figure 5.…”