Effect Of Human Milk-Based Fortification in Extremely Preterm Infants Fed Exclusively with Breast Milk: A Randomised Controlled Trial

Association of Fortification with Human Milk versus Bovine Milk-Based Fortifiers on Short-Term Outcomes in Preterm Infants—A Meta-Analysis

“…Twenty-two full-text articles were assessed. A final total of 4 articles including 3 RCTs [ 14 , 15 , 16 ], and 1 non-randomized study of interventions (NRSIs) were deemed eligible to be included in the final meta-analysis ( Table 1 ).…”

“…In the OptiMoM, Sullivan and Jensen trials, the diagnosis of NEC was made by radiologists, who were blind to the dietary assignment to improve diagnostic reliability. Final assessment of NEC diagnosis was performed by a blinded consensus panel review in the Jensen study [ 14 ].…”

“…All included studies [ 14 , 15 , 16 , 18 ] used BPD as need for oxygen requirement at 36 weeks postmenstrual age.…”

“…Two studies examined severe ROP [ 15 , 16 ], and one examined all ROP [ 18 ]. ROP was diagnosed in the Jensen study after postmenstrual week 42 + 0 according to international classification into stages I–V [ 14 ]. We opted to combine the four studies despite heterogeneity.…”

“…Both in the Jensen study [ 14 ] and in the OptiMom [ 15 ] study feeding intolerance was quantitated by the number of days that feeding was withheld for ≥12 h due to gastric residuals greater than 50% of the prior feeding or more than 2 mL/kg, bile- or bloodstained gastric residuals, emesis, abdominal distention or tenderness, changes in stool pattern or consistency, or presence of blood in the stool.…”