Effect of Human Infant Gut Microbiota on Mouse Behavior, Dendritic Complexity, and Myelination
Harikesh Dubey,
Rohon Roychoudhury,
Ann Alex
et al.
Abstract:The mammalian gut microbiome influences numerous developmental processes. In human infants it has been linked with cognition, social skills, hormonal responses to stress, and brain connectivity. Yet, these associations are not necessarily causal. The present study tested whether two microbial stool communities, common in human infants, affected behavior, myelination, dendritic morphology, and spine density when used to colonize mouse models. Humanized animals were more like specific-pathogen free mice than ger… Show more
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