Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis

Umekita, Kunihiko

doi:10.3390/v14071460

Cited by 7 publications

(10 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 HTLV-1 induced anticitrullinated protein antibody autoantibody production and was significantly higher in RA patients. 6 In addition, human papillomaviruses (HPVs), herpes simplex virus (HSV) I, and HSV II have been associated with infertility, miscarriage, cervical disease, and cancer. [8][9][10][11] The effects of HSV and HPV on RA are not fully elucidated.…”

mentioning

confidence: 89%

“…The viral structural particle of EBV induced RA-like bone erosion in virus-infected humanized mice 7 . HTLV-1 Tax and HBZ protein increased proinflammatory cytokines autoantibody production in the model of transgenic mice 6 . HTLV-1 induced anticitrullinated protein antibody autoantibody production and was significantly higher in RA patients 6 .…”

mentioning

confidence: 99%

“…[2][3][4] The infection of EBV and human T-cell leukemia virus type 1 (HTLV-1) etiologically contributes to the development of RA. 5,6 The viral structural particle of EBV induced RA-like bone erosion in virus-infected humanized mice. 7 HTLV-1 Tax and HBZ protein increased proinflammatory cytokines autoantibody production in the model of transgenic mice.…”

mentioning

confidence: 99%

“…Human endogenous retrovirus, cytomegalovirus, Epstein-Barr virus (EBV), and herpesviruses 6 and 8 in RA have been demonstrated to affect inflammatory autoimmune diseases 2–4 . The infection of EBV and human T-cell leukemia virus type 1 (HTLV-1) etiologically contributes to the development of RA 5,6 . The viral structural particle of EBV induced RA-like bone erosion in virus-infected humanized mice 7 .…”

mentioning

confidence: 99%

See 3 more Smart Citations

Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults

Fu,

Lin,

Chang

2023

J Clin Rheumatol

View full text Add to dashboard Cite

Background/Objective The potential correlation between herpes simplex virus (HSV) and human papillomavirus (HPV) infections and rheumatoid arthritis (RA) has not been definitively established. Further research is needed to determine the relationship between the development of RA and the presence of these viral infections. Methods A retrospective case-control study was conducted with data from the National Health and Nutrition Examination Survey between 2009 and 2014. Our analysis examined the association between HSV I, HSV II, HPV oral polymerase chain reaction (PCR), HPV vaginal PCR, and RA. We identified adults aged 20 to 49 years with a primary diagnosis of RA using the National Health and Nutrition Examination Survey database codes (MCQ191 = 1 [years 2009–2010]; MCQ195 = 2 [years 2011–2014]) and excluded patients with incomplete data on key variables and primary outcomes. Results The study included 8620 patients, with 150 patients diagnosed with RA and 1500 patients without RA. Patients with RA had a significantly higher prevalence of HSV II infection compared with those without RA (36.34% vs. 24.72%, p = 0.015) after propensity score matching. No significant differences were observed for HSV I, HPV oral PCR, and HPV vaginal PCR between the 2 groups. Patients with RA were older; were more likely to be female, obese, and non-Hispanic White; and had a higher prevalence of comorbidities than those without RA. Conclusions This population-based propensity score–matching study provides evidence of an association between HSV II infection and RA in US adults. Further research is needed to fully elucidate the relationship between viral infections and RA, with the aim of developing effective risk reduction strategies and innovative treatments for RA.

show abstract

mentioning

confidence: 89%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults

Fu,

Lin,

Chang

2023

J Clin Rheumatol

View full text Add to dashboard Cite

show abstract

“…Several inflammatory diseases, such as Sjögren’s syndrome [ 67 ], myositis [ 68 ], uveitis [ 69 ], pulmonary disorder [ 70 ], arthritis [ 71 ], and infective dermatitis [ 72 ], occasionally occur in HTLV-1-infected individuals, including HAM/TSP patients [ 21 ]. Although it is necessary to consider the pathogenesis in those complicated with HAM/TSP in distinction from those complicated with HTLV-1 carrier status, at least, the exact pathogenesis of these inflammatory diseases is still obscure.…”

Section: Other Inflammatory Diseases In Ham/tsp Patientsmentioning

confidence: 99%

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

Nakamura

2023

Pathogens

View full text Add to dashboard Cite

Slowly progressive spastic paraparesis with bladder dysfunction, the main clinical feature of human T-cell leukemia virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), is induced by chronic inflammation in the spinal cord, mainly the lower thoracic cord. A long-standing bystander mechanism, such as the destruction of surrounding tissues by inflammatory cytokines, etc., induced under the interaction between infiltrated HTLV-1-infected CD4+ T cells and HTLV-1-specific CD8+ cytotoxic T cells, has been considered implicated for the induction of chronic inflammation. As this bystander mechanism is triggered conceivably by the transmigration of HTLV-1-infected CD4+ T cells to the spinal cord, heightened transmigrating activity of HTLV-1-infected CD4+ T cells to the spinal cord might play a crucial role as the first responder in the development of HAM/TSP. This review evaluated the functions of HTLV-1-infected CD4+ T cells in HAM/TSP patients as the prerequisite for the acquisition of the activity such as adhesion molecule expression changes, small GTPases activation, and expression of mediators involved in basement membrane disruption. The findings suggest that HTLV-1-infected CD4+ T cells in HAM/TSP patients have enough potential to facilitate transmigration into the tissues. Future HAM/TSP research should clarify the molecular mechanisms leading to the establishment of HTLV-1-infected CD4+ T cells as the first responder in HAM/TSP patients. In addition, a regimen with an inhibitory activity against the transmigration of HTLV-1-infected CD4+ T cells into the spinal cord might be recommended as one of the therapeutic strategies against HAM/TSP patients.

show abstract

Accelerating Cancer Vaccine Development for Human T-Lymphotropic Virus (HTLV) Using a High-Throughput Molecular Dynamics Approach

Moin,

Rani,

Ullah

et al. 2023

Preprint

View full text Add to dashboard Cite

Human T-lymphotropic virus (HTLV), a retrovirus belonging to the oncovirus family, has long been linked to be associated with various inflammatory and immunosuppressive disorders. To combat the devastating impact of this virus, our study employed a reverse vaccinology approach to design a multi-epitope-based vaccine targeting the highly virulent subtypes of HTLV. We conducted a comprehensive analysis of the molecular interactions between the vaccine and Toll-like receptors (TLRs), providing valuable insights for future research on preventing and managing HTLV-related diseases and any possible outbreaks. The vaccine was designed by focusing on the envelope glycoprotein gp62, a crucial protein involved in the infectious process and immune mechanisms of HTLV inside the human body. Epitope mapping identified T cell and B cell epitopes with low binding energies, ensuring their immunogenicity and safety. Linkers and adjuvants were incorporated to enhance the vaccine's stability, antigenicity, and immunogenicity. Two vaccine constructs were developed, both exhibiting high antigenicity and conferring safety. Vaccine construct 2 demonstrated expected solubility and structural stability after disulfide engineering. Molecular docking analyses revealed strong binding affinity between the vaccine construct 2 and both TLR2 and TLR4. Molecular dynamics simulations indicated that the TLR2-vaccine complex displayed enhanced stability, compactness, and consistent hydrogen bond formation, suggesting a favorable affinity. Contact analysis, Gibbs free energy landscapes, and DCC analysis further supported the stability of the TLR2-vaccine complex, while DSSP analysis confirmed stable secondary structures. MM-PBSA analysis revealed a more favorable binding affinity of the TLR4-vaccine complex, primarily due to lower electrostatic energy. In conclusion, our study successfully designed a multi-epitope-based vaccine targeting HTLV subtypes and provided valuable insights into the molecular interactions between the vaccine and TLRs. These findings should contribute to the development of effective preventive and treatment approaches against HTLV-related diseases.

show abstract

Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis

Cited by 7 publications

References 109 publications

Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults

Association Between Herpes Simplex Virus II Infection and Rheumatoid Arthritis in US Adults

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues

Accelerating Cancer Vaccine Development for Human T-Lymphotropic Virus (HTLV) Using a High-Throughput Molecular Dynamics Approach

Contact Info

Product

Resources

About