Effect of Hospital Volume on Clinical Outcome in Patients With Acute Pancreatitis, Based on a National Administrative Database

Abstract

This study demonstrated that hospital volume influences the clinical outcome in both patients with mild and those with severe acute pancreatitis.

Effects of proton pump inhibitor on outcomes of patients with severe acute pancreatitis based on a national administrative database

“…Acute pancreatitis is defined as an acute inflammatory condition of the pancreas that may involve peripancreatic tissues or remote organ systems [1,2]. The incidence of acute pancreatitis still remains high [3].…”

“…Acute pancreatitis has a wide spectrum of clinical courses, ranging from a mild to a severe form, and severe acute pancreatitis is still associated with a high mortality, despite continuing improvements in critical care [1][2][3]. With regard to the management of severe acute pancreatitis, some clinical practice guidelines have introduced basic treatments, such as use of antimicrobial drugs or protease inhibitors, as well as specific procedures, such as continuous regional arterial infusion or surgical drainage [7][8][9].…”

Mortality following acute pancreatitis: social deprivation, hospital size and time of admission: record linkage study

“…Little has also been reported on the relationship between social deprivation and mortality following acute pancreatitis [3]. Studies relating mortality to volume of acute pancreatitis cases have mostly reported lower mortality in hospitals with high volumes of cases, for example, in Sweden [18], the USA [19], Japan [20] and Taiwan [21], but there have been no reports on this from the UK. In a previous study we noted that the hospital admission rate for alcoholic acute pancreatitis was linked positively with consumption of spirits and beer but negatively with wine, and was increased during the Christmas holiday and with high levels of social deprivation [22].…”

Time Trend of Outcomes for Severe Acute Pancreatitis After Publication of Japanese Guidelines Based on a National Administrative Database

“…[1][2][3] This medical condition has a spectrum of clinical courses, ranging from a mild form with minimal morbidity to a severe form with a high incidence of systemic complications, such as systemic inflammatory response syndrome and multiple organ failure. [2][3][4] Severe acute pancreatitis is characterized as a high-mortality disease despite continuing improvements in critical care. 4,5 Therefore, severe acute pancreatitis has been recognized as a life-threatening disease with a poor prognosis.…”