Effect of Hormones on the Human Fetal Prostate

Zondek, Lilly H.; Zondek, Theodor

doi:10.1159/000402469

Cited by 6 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elongation and branching morphogenesis of human prostatic buds has been illustrated in several reports (Zhu et al, 2007; Adams et al, 2002; Dauge et al, 1986; Sebe et al, 2005; Xue et al, 2000; Wernert et al, 1987; Xia et al, 1990; Zondek and Zondek, 1979; Timms et al, 1994; Timms, 2008; Timms and Hofkamp, 2011). For many of these papers the analysis is exclusively histologic.…”

Section: Introductionmentioning

confidence: 91%

“…The actual emergence of prostatic buds from the human fetal UGS is said to occur at 9 to 10 weeks of gestation: 9.5 weeks (Dauge et al, 1986), 10 weeks (Kellokumpu- Lehtonen et al, 1980), and in a 40-to 60-mm crown rump fetus (9 to 10 week) (Zondek and Zondek, 1979). The reported age range described above is likely due to the inherent difficulty of estimating specimen age as described below.…”

Section: Introductionmentioning

confidence: 99%

“…The focus in their paper was squamous metaplasia within the developing human prostate, which they proposed was due to a balance between estrogen and androgen action. They suggested “that diminished androgen production (due to ancephaly) led to a disturbance in the hormonal balance and was thus at least partly responsible for the extreme metaplastic changes in the organ” (Zondek and Zondek, 1979).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of the human prostate

et al. 2018

View full text Add to dashboard Cite

This paper provides a detailed compilation of human prostatic development that includes human fetal prostatic gross anatomy, histology, and ontogeny of selected epithelial and mesenchymal differentiation markers and signaling molecules throughout the stages of human prostatic development: (a) pre-bud urogenital sinus (UGS), (b) emergence of solid prostatic epithelial buds from urogenital sinus epithelium (UGE), (c) bud elongation and branching, (d) canalization of the solid epithelial cords, (e) differentiation of luminal and basal epithelial cells, and (f) secretory cytodifferentiation. Additionally, we describe the use of xenografts to assess the actions of androgens and estrogens on human fetal prostatic development. In this regard, we report a new model of de novo DHT-induction of prostatic development from xenografts of human fetal female urethras, which emphasizes the utility of the xenograft approach for investigation of initiation of human prostatic development. These studies raise the possibility of molecular mechanistic studies on human prostatic development through the use of tissue recombinants composed of mutant mouse UGM combined with human fetal prostatic epithelium. Our compilation of human prostatic developmental processes is likely to advance our understanding of the pathogenesis of benign prostatic hyperplasia and prostate cancer as the neoformation of ductal-acinar architecture during normal development is shared during the pathogenesis of benign prostatic hyperplasia and prostate cancer.

show abstract

Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of the human prostate

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Prostatic squamous metaplasia and the complications of alphafetoprotein in the neonatal mouse: The developing human prostate is susceptible to effects of the high levels of maternal estrogens in the third trimester (Boroditsky et al, 1978;Dawson et al, 1983). Prostatic squamous metaplasia is a striking and consistent manifestation of maternal estrogens in the third trimester (Zondek and Zondek, 1979). In contrast, spontaneous prostatic squamous metaplasia has never been reported in mice, even though prostatic squamous metaplasia can be induced in mice by exogenous estrogens such as estradiol or diethylstilbestrol (DES) (Risbridger et al, 2001).…”

Section: Prostatementioning

confidence: 99%

“…Thus, endogenous serum estrogen of either fetal or maternal origin is sequestered in mice and is not available for entry into target cells. In contrast, human AFP does not bind estrogens (Swartz and Soloff, 1974), and thus in humans, endogenous and exogenous estrogens are free to interact with target cells and to elicit prostatic squamous metaplasia (and in females stimulate breast, uterus and vagina) during the perinatal period (Driscoll and Taylor, 1980;Yonemura et al, 1995;Zondek and Zondek, 1979). After birth prostatic squamous metaplasia disappears.…”

Section: Prostatementioning

confidence: 99%

Reproductive tract biology: Of mice and men

et al. 2019

View full text Add to dashboard Cite

The study of male and female reproductive tract development requires expertise in two separate disciplines, developmental biology and endocrinology. For ease of experimentation and economy, the mouse has been used extensively as a model for human development and pathogenesis, and for the most part similarities in developmental processes and hormone action provide ample justification for the relevance of mouse models for human reproductive tract development. Indeed, there are many examples describing the phenotype of human genetic disorders that have a reasonably comparable phenotype in mice, attesting to the congruence between mouse and human development. However, anatomic, developmental and endocrinologic differences exist between mice and humans that (1) must be appreciated and (2) considered with caution when extrapolating information between all animal models and humans. It is critical that the investigator be aware of both the similarities and differences in organogenesis and hormone action within male and female reproductive tracts so as to focus on those features of mouse models with clear relevance to human development/pathology. This review, written by a team with extensive expertise in the anatomy, developmental biology and endocrinology of both mouse and human urogenital tracts, focusses upon the significant human/mouse differences, and when appropriate voices a cautionary note regarding extrapolation of mouse models for understanding development of human male and female reproductive tracts.

show abstract

Embryonal hyperplasia of the prostate

Bennett¹,

Gardner²

1985

The Prostate

View full text Add to dashboard Cite

Unusual patterns of prostatic hyperplasia require close scrutiny by the pathologist in order to distinguish them from adenocarcinoma. One such pattern, basal cell hyperplasia, has been the subject of several recent reports. We describe a second pattern, which we refer to as embryonal hyperplasia because of its resemblance to the embryonal or fetal prostate. Although this lesion bears some resemblance to basal cell hyperplasia, it differs in histochemical characteristics. A review of previous cases of this entity, which were reported as basal cell hyperplasia, suggests that they differ in ultrastructural characteristics as well. The significance of this proliferative pattern currently rests in its resemblance to prostatic adenocarcinoma, particularly when present in many chips from a transurethral resection of the prostate. Further studies, especially relating to hormone dependency, would be useful in understanding the development of this and other more atypical prostatic proliferations.

show abstract

Effect of Hormones on the Human Fetal Prostate

Cited by 6 publications

References 0 publications

Development of the human prostate

Development of the human prostate

Reproductive tract biology: Of mice and men

Embryonal hyperplasia of the prostate

Contact Info

Product

Resources

About