Effect of honey on febrile neutropenia in children with acute lymphoblastic leukemia: A randomized crossover open-labeled study

Abdulrhman, Mamdouh; Hamed, Ahmad A.; Mohamed, S. A.; Hassanen, Nouran Abdel Aal

doi:10.1016/j.ctim.2016.01.009

Cited by 25 publications

(27 citation statements)

References 19 publications

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“…Another study found febrile period which is mostly a consequence of neutropenia in patients receiving chemotherapy, diminished significantly (p<0.05) (19) . Similarly was previously reported with honey consumption improved the levels of hemoglobi (25) .…”

Section: Discussionsupporting

confidence: 83%

Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

Gendy

Sayed²,

Alfy³

et al. 2018

Egyptian Journal of Hospital Medicine

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Background: the treatment of cancer is associated with nausea and vomiting, oral mucositis, constipation, xerostomia and diarrhea and weight loss, additionally; chemotherapeutic agents promote inflammatory changes in the gut, intestinal necrosis, and anaerobic conditions, allowing proliferation of Clostridium Difficile. Honey, as a natural honeybee product, has antioxidant, antimicrobial, immunomodulatory and anticancer effects. Honey can fight microbial infection by its immuno-activating, anti-inflammatory and prebiotic activity. Objectives: the aim of this study was to evaluate the effect of honey supplementation on frequency of Clostridium Difficile infection (CDI) and gastrointestinal complications in pediatric patients undergoing chemotherapy. Design: a cross sectional study conducted on 40 patients with malignancy recruited from Children's Hospital, Ain Shams University, Oncology Unit and Clinic, Cairo, Egypt in the period from December 2015 to December 2016. Patients were divided into two groups; group I (25 patients) received honey in the dose of 2gm/kg 3 times dailyfor 1month) while group II (15 patients) did not receive honey. All the studied patients were subjected to medical history and clinical examination, with special emphasis on gastrointestinal complication including oral mucositis, vomiting, diarrhea, constipation, and abdominal pain. Follow up was done for weight, height z score, gastrointestinal complications and any adverse events. Stool analysis, culture, C difficle toxin A, B by ELISA was done to all patients at baseline and repeated to patients receiving honey at week 4 of supplementation. Main outcome measure frequency of CDI, gastrointestinal complication, febrile neutropenia. Results: the frequency of C difficle was 8% (2), the first case was 9 years old patient with ALL (50%) and the other 11 years old patient with Burkitts lymphoma both were diagnosed by positive stool culture and positive stool ELISA for toxin A, B. gastrointestinal complications were significantly less and improved in the supplemented group and mean of hemoglobin significant increase in group 1. Conclusion: the frequency of CDI in children with cancer 8% diagnosed by stool culture and toxin A, B study in stool. Honey improved the oral mucositis and different GIT complications associated with chemotherapy.

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Section: Discussionsupporting

confidence: 83%

Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

Gendy

Sayed²,

Alfy³

et al. 2018

Egyptian Journal of Hospital Medicine

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“…Abdul Rahman et al (2016) studied children with acute lymphoblastic leukemia (ALL) and found that the oral administration of 2.5 g/kg of clover honey twice a week for three months increased the level of hemoglobin without causing side effects. In this cross-sectional study, discontinuation of taking honey at a later period decreased hemoglobin level, total neutrophil count, and platelet count (21).…”

Section: Introductionmentioning

confidence: 62%

“…The reason for these findings is probably due to the specific conditions of the research units (the hemodialysis patients), but not due to the type of intervention (thyme honey), resulting in no effect of the intervention. Most previous studies that reported the positive effects of honey administration on slightly or significantly elevated hemoglobin levels mainly used amber and dark honeys, such as Manuka, Tualang, Clover and Carob honey (16,17,21). These honeys have high levels of phenolic compounds, minerals (iron, copper, etc) and antioxidant properties, which have hepatoprotective effects and positive effects on red blood cell production by stimulating bone marrow (17).…”

Section: Discussionmentioning

confidence: 99%

The effect of thyme honey on anemia in hemodialysis patients

Kiasari

Nobahar

Ghorbani

et al. 2020

NPT

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Background & Aim: Anemia is one of the most common complications of chronic renal failure, which is associated with increased fatigue, dyspnea, depression, malaise, prolonged hospitalization and mortality. Some patients are resistant to erythropoietin therapy. Therefore, the purpose of this study was to determine the effect of thyme honey on anemia in hemodialysis patients. Methods & Materials: The present clinical trial was conducted in 2018 at Kowsar Hospital of Semnan on hemodialysis patients randomly selected with convenience sampling method within two groups of case (n=28) and control (n=27). The case group received thyme honey (33 g) daily for one month. The control group did not consume thyme honey. Blood samples were taken from the patients before and after the intervention with 10-hour fasting and then blood parameters were assessed. Results: The mean ±SD reduction rate in hemoglobin level was 0.46±0.96 in the case group and 0.23±3.15 g/dl in the control group, but no significant difference using independent t-test (P=0.758). The mean±SD reduction rate in hematocrit percentages was 1.20±2.78 in the case group and 0.11±8.53 in the control group, but there is no significant difference between the two groups using independent t-test (P=0.590). Conclusion: Results showed that daily administration of 33 grams of thyme honey had no effect on anemia in hemodialysis patients. Further studies are recommended with modification of the methodology regarding the type, dose, duration and instructions of honey consumption for better results.

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“…Febrile neutropenia is a common negative result of chemotherapy, and the present treatment for it is costly and may prompt adverse effects. Abdulrhman et al (2016) investigated the influence of Egyptian honey on febrile neutropenia in children with acute lymphoblastic leukemia. Forty patients male and female aged 2.5-10 years with acute lymphoblastic leukemia were randomly allocated into two equal groups, intervention to control (I/C) and control to intervention (C/I).…”

Section: Effect Of Honey On Febrile Neutropeniamentioning

confidence: 99%

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

Tahir

Mariod

Mahunu

et al. 2019

Journal of Apicultural Science

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Honey production in Africa is considered an integral part of folk medicine and provides an opportunity for poor rural communities to increase their economic sustainability. In this review, we provide and discuss the data available on the positive nutritional value and health properties of honey harvested from Africa. Besides sugar, honey contains protein and amino acids, with proline which is about 50% of the total amino acids, vitamins, enzymes, some minerals (Na, K, Mg, Ca, Zn, Cu, Mn, Fe, P, S), trace elements (Mn, Ni, Li, F, I, Cl, Sr, Co) and polyphenol compounds. The paper reviewed studies on the use of African honey with anti-inflammatory, antioxidant, antibacterial, antifungal, anti-breast cancer, antidiabetic and antimycotic properties and also its positive effects on infertility (asthenozoospermia), febrile neutropenia and diabetic foot ulcers.

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Effect of honey on febrile neutropenia in children with acute lymphoblastic leukemia: A randomized crossover open-labeled study

Cited by 25 publications

References 19 publications

Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

Effect of Honey Supplementation on Clostridium Difficile Infection in Childhood Cancer

The effect of thyme honey on anemia in hemodialysis patients

Chemical Composition, Nutritional Functions, and Antioxidant Activities of Honeys in Africa

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