Effect of honey dressing in the management of diabetic foot ulcers: A meta‐analysis

Li, Shaoting; Xiao, Ting; Ye, Ning; Yang, Guosheng; Chen, Haiting; Xia, Liang; Li, Tuodi; Wang, Jinying; Peng, Yaozhong; Li, Yuan; Liu, Yanping

doi:10.1111/iwj.14135

Cited by 4 publications

(2 citation statements)

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“…Additionally, ulcer healing following these treatments is reported to be poor and time‐consuming 11 . Hence, several adjuvant approaches have been recently investigated for the treatment of DFU, such as human amniotic membrane allograft, 12 recombinant human epidermal growth factor, 13 laser therapy, 14 platelet‐rich plasma, 15 hyperbaric oxygen therapy 16 and modern dressings 17 . However, the use of these adjuvant treatments is not without concerns, and the best strategies for the healing of DFU continue to be a challenge 18 .…”

Section: Introductionmentioning

confidence: 99%

“… 11 Hence, several adjuvant approaches have been recently investigated for the treatment of DFU, such as human amniotic membrane allograft, 12 recombinant human epidermal growth factor, 13 laser therapy, 14 platelet‐rich plasma, 15 hyperbaric oxygen therapy 16 and modern dressings. 17 However, the use of these adjuvant treatments is not without concerns, and the best strategies for the healing of DFU continue to be a challenge. 18 Thus, to find new cost‐effective and safe interventions for better management of DFU, it is necessary to investigate the potential effects of other alternative therapies using an evidence‐based approach.…”

Section: Introductionmentioning

confidence: 99%

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Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta‐analysis of randomized controlled trials

Zamanifard,

Nasiri,

Yarahmadi

et al. 2024

International Wound Journal

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This systematic review aimed to qualitatively synthesize recent randomized controlled trials (RCTs) regarding the effect of topical application and oral intake of herbal products on the healing of diabetic foot ulcer (DFU). Also, we sought to pool the obtained findings in a meta‐analysis using a random‐effects model, if RCTs were relatively comparable and homogenous. A comprehensive search was performed on five electronic data sources from their inception through 23 January 2024. The RCTs, without restriction on the country of origin, were included if they compared the effect of administering standard treatments and/or placebo (i.e. control condition) to applying standard treatments and/or herbal products in topical or oral routes (i.e. experimental condition). Out of 1166 retrieved records, 28 RCTs were included. Studies used different poly and single herbal formulations. Based on the meta‐analysis, administration of standard care plus daily dressing of the ulcer site with olive oil for 28 days significantly increased the total ulcer healing score (3 RCTs; weighted mean difference [WMD] = 89.30; p < 0.001), raised frequency of complete ulcer healing (2 RCTs; risk ratio [RR] = 12.44; p = 0.039) and declined ulcer degree (3 RCTs; WMD = −22.28; p = 0.002). Also, daily use of the bitter melon leaf extract in oral form for 28 days significantly increased the total ulcer healing score (2 RCTs; WMD = 0.40; p = 0.001). Additionally, based on qualitative synthesis, the adjuvant use of herbal agents seems an intriguing choice to manage DFU. Nonetheless, considering the undesirable methodological quality of most studies and the high heterogeneity in administered herbal formulations, more robust trials are required to build a solid conclusion regarding the use of herbal products for healing DFU.

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