Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention. the swiss heart study: a randomized controlled trial

Schnyder, Guido; Roffi, Marco; Flammer, Yvonne; Pin, Riccardo; Hess, Otto M.

doi:10.1016/s1062-1458(02)01039-5

Cited by 123 publications

(149 citation statements)

References 38 publications

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“…Some clinical trials of homocysteine lowering through B-vitamin treatment support a cardioprotective effect (Schnyder et al, 2001(Schnyder et al, , 2002, but others do not (Baker et al, 2002;Lange et al, 2004;Toole et al, 2004;Bonaa et al, 2006;HOPE 2 Investigators, 2006).…”

Section: Discussionmentioning

confidence: 99%

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women

et al. 2007

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Objective: To investigate the association between dietary intakes of folate, betaine and choline and the risk of cardiovascular disease (CVD). Design: Prospective cohort study. Subjects: A total of 16 165 women aged 49-70 years without prior CVD. Subjects were breast cancer screening participants in the PROSPECT-EPIC cohort, which is 1 of the 2 Dutch contributions to the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Each participant completed a validated food frequency questionnaire. Folate intake was calculated with the Dutch National Food Database. Betaine and choline intakes were calculated with the USDA database containing choline and betaine contents of common US foods. Data on coronary heart disease (CHD) events and cerebrovascular accident (CVA) events morbidity data were obtained from the Dutch Centre for Health Care Information. Results: During a median follow-up period of 97 months, 717 women were diagnosed with CVD. After adjustment, neither folate, nor betaine, nor choline intakes were associated with CVD (hazard ratios for highest versus lowest quartile were 1.23 (95% confidence interval 0.75; 2.01), 0.90 (0.69; 1.17), 1.04 (0.71; 1.53), respectively). In a subsample of the population, high folate and choline intakes were statistically significantly associated with lower homocysteine levels. High betaine intake was associated with slightly lower high-density lipoprotein (HDL)-cholesterol concentrations. Conclusion: Regular dietary intakes of folate, betaine and choline were not associated with CVD risk in post-menopausal Dutch women. However, the effect of doses of betaine and choline beyond regular dietary intake -for example, via supplementation or fortification -remains unknown.

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Section: Discussionmentioning

confidence: 99%

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women

et al. 2007

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“…Furthermore, vitamin B 6 and folate have little effect on plasma homocysteine concentration when individuals have an adequate vitamin B 6 and folate status (Huang et al, 2003). In The Swiss Heart Study, homocysteine-lowering therapy with folic acid, vitamin B 12 and vitamin B 6 significantly decreases the incidence of major events after percutaneous coronary intervention (Schnyder et al, 2002). Even though Taiwanese vegetarians were found to have higher plasma homocysteine levels than omnivores (8.44 vs 10.97 mmol/l), they are still way below the hyperhomocysteinemia (level of homocysteine414 mmol/l), whether dietary supplementation with vitamin B 12 would lower homocysteine levels and have additional benefits on top of the cardiovascular protective effects of vegetarian diets, remains to be studied.…”

Section: Vitamin Supplementationmentioning

confidence: 99%

Total cardiovascular risk profile of Taiwanese vegetarians

Chen

Lin

et al. 2007

Eur J Clin Nutr

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Background: Although the health benefits of vegetarian diets have been well documented among Western population, there are geographic differences of vegetarian diets and the health benefits of the Taiwanese vegetarian diet have not been studied extensively. In addition to conventional risk factors, homocysteine and high-sensitivity C-reactive protein (hs-CRP) levels have been found to predict first atherothrombotic events. We undertook this study to examine the total risk profile of Taiwanese vegetarians. Methods: A total of 198 healthy subjects (99 vegetarians and 99 omnivores) were recruited. Fasting blood samples were analyzed for glucose, cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell count, hs-CRP and homocysteine. Results: There was no significant difference in age, body mass index, blood glucose, white blood cell count, triglyceride and HDL-C between the two groups. The vegetarian group had significantly more females (65.7 vs 46.5%); lower body weight (58.66711.13 vs 62.88712.24 kg); shorter height (159.1477.88 vs 162.53 78.14 cm); lower total cholesterol (184.74733.23 vs 202.01741.05 mg/dl); and lower LDL-C (119.63731.59 vs 135.89739.50 mg/dl). Hs-CRP was significantly lower (0.1470.23 vs 0.2370.44 mg/dl, P ¼ 0.025), whereas homocysteine was significantly higher (10.9776.69 vs 8.4472.50 mmol/l, P ¼ 0.001) in vegetarians than omnivores. Conclusions: Taiwanese vegetarians have lower total cholesterol, LDL-C and hs-CRP levels, and higher homocysteine levels than omnivores. Owing to different predictive value of each risk factor, the Taiwanese vegetarians had a better cardiovascular risk profile than omnivores. Whether the Taiwanese vegetarian diet should be supplemented with vitamin B 12 to lower serum homocysteine level remains to be addressed.

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“…This too was lower in the treated patients, but was principally the result of a reduced rate of target lesion revascularization. 16 In a larger, open-label study, patients with stable coronary artery disease were given folic acid and followed for a mean of 2 years. Plasma homocysteine levels fell by 18%, but all-cause mortality and a composite end point of vascular events were not significantly reduced.…”

Section: See P 369mentioning

confidence: 99%

Renal Disease, Homocysteine, and Cardiovascular Complications

Robinson

2004

Circulation

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Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention. the swiss heart study: a randomized controlled trial

Cited by 123 publications

References 38 publications

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women

Prospective study on dietary intakes of folate, betaine, and choline and cardiovascular disease risk in women

Total cardiovascular risk profile of Taiwanese vegetarians

Renal Disease, Homocysteine, and Cardiovascular Complications

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