Effect of Homocysteine and Vitamin D in Polycystic Ovary Syndrome with Iraqi Women

Abstract

This research has been carried out on the effect of some biochemical parameters on women with polycystic ovaries. The presented work aims to determine the levels of a few biochemical parameters in females with polycystic ovaries syndrome (PCOS) attending the Department of Biotechnology, College of Science, University of Baghdad’s. The study comprised 35 women between 18 and 35 who had PCOS based upon complete Rotterdam criteria. The control group comprised 35 healthy females of one age who had a regular menstrual cycle. The results indicated that females with PCOS have been obese or overweight when their body mass index (BMI) was more than 30. Insulin, fasting blood sugar (FBS), glycated hemoglobin (HbA1c%), and homeostatic model assessment for insulin resistance (HOMA-IR) have all been higher (≤ 0.05) in females with PCOS in comparison with a control group, showing that insulin resistance (IR) has been present. Total cholesterol (TC) and low-density lipoprotein (LDL) levels have been higher (≤ 0.05). Still, very-low-density lipoprotein (VLDL) and triglycerides (TG) levels were within the normal reference range without considerable differences compared to the control group. High-density lipoprotein (HDL) has been lower than the control group. According to this work, the majority of females with PCOS had a high BMI. Those patients showed signs of IR. It was discovered that the patient had dyslipidemia. Those results vary from previous studies that found no evidence of IR. The primary goal of this work is to assess the effects of homocysteine and vitamin D in females who have PCOS, and the findings revealed a significant increase in the homocysteine levels and a considerable drop or deficiency in vitamin D in Iraqi females who have PCOS.

Estimation of Spexin level and some biochemical indicators in obese and non-obese woman's with polycystic ovary syndrome

“…According to Table (1) , showed no statistically differences in the value in BMI between two groups, but there was a significant difference in the BMI value (P0.01), obese women with PCOS were compared to non-obese patients. This information was used to determine the prevalence of obesity among patients (PCOS) concur with those of Al-Mahdawi and his team's study (14) Those who indicated no differences in body mass index in obese PCOS women compared with the control group, while the results of this study contradicted the results of the study of Esmaeilzadeh and his group (15) , as they found that women with polycystic ovary syndrome have a body mass index Significantly higher than in the control group, higher mean weight gain was indicated to be associated with less exerciseSports among women and wrong eating habits with high calories approved. (16) .…”