Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non–small cell lung carcinoma

Okada, Morihito; Nishio, Wataru; Sakurai, Toshihiko; Uchino, Kenji; Yuki, Tsuyoshi; Nakagawa, Akio; Tsubota, Noriaki

doi:10.1016/j.athoracsur.2004.03.019

Cited by 50 publications

(56 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result, CEA level was the only tumor marker that was found to be significantly different between patients with BM and without BM. Although some studies indicated that the prognostic value of CEA was more specific in adenocarcinoma patients than in SCC patients, it should be noticed that less than one third of patients enrolled in these studies had SCC histology [26,28]. Since our findings were concluded in SCC patients, we believed that, at least in patients with SCC, those with abnormal serum levels of CEA at diagnosis should be considered as at risk population of BM.…”

Section: Discussionmentioning

confidence: 90%

Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center

Liu

et al. 2017

Chin Neurosurg Jl

View full text Add to dashboard Cite

Background: To explore risk factors and the efficacy of treatment strategies for brain metastasis (BM) in squamous cell carcinoma (SCC) of the lung. Methods: The clinical data of 188 pathologically confirmed as squamous cell carcinoma or adenosquamous carcinoma patients were studied retrospectively. Factors including age (<60 vs. ≥60), gender, stage at diagnosis, T status (T1-2 vs. T3-4), N status (N0-1 vs. N2-3), histology (squamous vs. adenosquamous), smoking history (non-smoker vs. current smoker) and serum tumor markers (normal vs. elevated) were analyzed. Results: The incidence of BM was 19.1% (36/188) in our cohort. Patients who were female (p = 0.005), had advanced disease at diagnosis (p < 0.001), had adenosquamous carcinoma histology (p = 0.033) or had elevated serum level of CEA at diagnosis (p < 0.001) had significantly higher incidence of BM. In multivariate analysis, female (p = 0.034, HR = 18.874) and elevated serum level of CEA at diagnosis (p = 0.009, HR = 19.824) were independent risk factors of BM. BM patients who received additional systemic therapy after local therapy had significantly longer post-BM survival than those who received local therapy only (p = 0.004, HR = 0.058). Gemcitabine/platinum-containing regimen (GP) and taxans/platinum-containing regimen (TP) led to comparable brain-metastasis-free survival (BMFS) (p = 0.10). Conclusions: Females and patients with elevated serum level of CEA at diagnosis had a higher risk of developing BM. The following systemic therapy after local therapy prolonged the survival of BM patient, but the efficacy of GP and TP was comparable in terms of preventing BM.

show abstract

Section: Discussionmentioning

confidence: 90%

Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center

Liu

et al. 2017

Chin Neurosurg Jl

View full text Add to dashboard Cite

show abstract

“…Some reports have indicated that CEA levels were significantly higher in patients with adenocarcinoma compared to patients with squamous cell carcinoma [31,34].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Said¹,

Abd-Elnaeem²,

Mohamed³

et al. 2015

J Clin Cell Immunol

View full text Add to dashboard Cite

show abstract

“…Alexander et al (25) found correlation between smoking and S-CEA levels, with levels being significantly higher in smokers than nonsmokers and with significantly higher percentage of smokers having elevated S-CEA levels; furthermore within 3 months of cessation of smoking, S-CEA levels did not appear to be influenced by previous smoking habits, with levels returning to a range that was characteristic of nonsmokers. Okada et al (26) reported that among nonsmokers, the rate of CEA positive patients was 21.5% for adenocarcinoma and 20% for squamous cell carcinoma. In contrast among smokers the rate of CEA positive patients was 49.3% for adenocarcinoma and 43.8% for squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…Several reports have indicated that S-CEA levels are significantly higher in patients with adenocarcinoma as compared to patients with squamous cell carcinoma (26)(27)(28)(29). Okada et al (26) reported that although S-CEA levels were significantly higher in patients with adenocarcinoma than in those with squamous cell carcinoma, but the proportion of CEApositive patients with adenocarcinoma (35.3%) was less than that of CEA-positive patients …”

Section: Discussionmentioning

confidence: 99%

Serum Carcinoembryonic Antigen Level as a Predictive Marker for Distant Metastasis in Non-Small Cell Lung Cancer

et al. 2007

View full text Add to dashboard Cite

Aim: Elevated serum CEA (S-CEA) levels are sometimes attributable to the production of CEA by malignant cells, and in turn, the antigen itself can enhance the metastatic potential of malignant cells. We investigated the predictive role of S-CEA level for distant metastasis in nonsmall cell lung cancer (NSCLC).Methods: Consecutive 116 NSCLC patients referred to our department were retrospectively investigated. S-CEA levels was compared according to age, gender, smoking habits, histological type, distant metastases and clinical disease stage in all patients.Results: There were no significant relationship between S-CEA level and age, gender and smoking habits. There was significant difference in S-CEA level between M0 and M1 patients (p<0.001). S-CEA levels were not significantly different between symptomatic and silent metastases NSCLC patients (p=0.103). We could not find significant differences in S-CEA levels between T1-2 and T3-4 (p=0.141), N0-1 and N2-3 (p=0.672). In NSCLC, the area under the ROC curve was 0.728 (p<0.001), S-CEA threshold of 6.4 ng/mL has predictive sensitivity and specificity, for distant metastases as 69.8% and 73.0% respectively. In multivariate analysis including age, gender, smoking status, histologic type and S-CEA level that only S-CEA levels qualified as an independent predictive factor for distant metastases (p=0.001).Conclusion: We conclude that S-CEA levels were significant for predicting distant metastases. High levels of S-CEA may be an indication to perform routine investigation of distant metastases even in the absence of symptoms and signs.

show abstract

Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non–small cell lung carcinoma

Cited by 50 publications

References 11 publications

Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center

Risk factors of brain metastasis of lung squamous cell carcinoma: a retrospective analysis of 188 patients from single center

Prognostic Value of CYFRA 21-1 and Carcinoembryonic Antigen in Non-Small Cell Lung Cancer

Serum Carcinoembryonic Antigen Level as a Predictive Marker for Distant Metastasis in Non-Small Cell Lung Cancer

Contact Info

Product

Resources

About