Effect of histidine administration to female rats during pregnancy and lactation on enzymes activity of phosphoryltransfer network in cerebral cortex and hippocampus of the offspring

Rojas, Denise Bertin; Andrade, Rodrigo; Gemelli, Tanise; Oliveira, Lenise Santos; Campos, Aline Alves Scarpellini; Dutra-Filho, Carlos Severo; Wannmacher, Clóvis Milton Duval

doi:10.1007/s11011-012-9319-5

Cited by 10 publications

(4 citation statements)

References 62 publications

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“…In the AM group, the levels of His, Phe, Thr, Glu, Met, and Gly were all abnormal. Abnormalities of single amino acids in circulating blood are closely related to the prevalence of diseases such as histidinemia (Rojas et al, 2012 ), hyperphenylalaninemia and hyperprolinemia (Pontoizeau et al, 2016 ), as well as other amino-acid-related metabolic diseases. These results suggest that the amino acid composition in the hyperproteinemic silkworm FBs were altered, implying that they have adverse effects on tissues and their related functions.…”

Section: Resultsmentioning

confidence: 99%

Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori

Chen

Wang

et al. 2018

Front. Physiol.

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Hyperproteinemia, which is characterized by an abnormally elevated plasma protein concentration (PPC), is a high-mortality, metabolic complication associated with severe liver and kidney disease. It is difficult to clinically distinguish the difference between the impacts of primary diseases and hyperproteinemia on tissues and organs, and there are no available animal models of hyperproteinemia. Here, we constructed an animal model of hyperproteinemia with a controllable PPC and no primary disease effects in the silkworm Bombyx mori that has attracted interest owing to its potential use in the pathological analysis of model animals. Silkworm have an open circulatory system in which each organ is directly immersed in hemolymph. The fat body (FB) of a silkworm, as a major organ for nutrient storage and energy metabolism, can effectively reflect hyperproteinemia-induced metabolic abnormalities in damaged visceral tissues. A pathogenesis study showed that hyperproteinemia attenuated cell autophagy and apoptosis by attenuating an endocrine hormone, thereby preventing FB remodeling during metamorphosis. Meanwhile, hyperproteinemia increased oxidative stress in the FB and resulted in a dysfunction of amino acid conversion. Supplementation with exogenous 20-hydroxyecdysone effectively mitigated the hyperproteinemia-mediated inhibition of FB remodeling.

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Section: Resultsmentioning

confidence: 99%

Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori

Chen

Wang

et al. 2018

Front. Physiol.

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“…This gene is associated with endometrial tumor when it is overexpressed, thus it is a marker for endometrial tumor. Rojas et al (2012) demonstrated that endometrial tumor can cause pregnancy failure. Kuang et al (2009) concluded that after embryo implantation, the chemokine (C-X-C motif) ligand 14 (CXCL14) gene can promote the growth and development of trophoblast.…”

Section: Discussionmentioning

confidence: 99%

A Transcriptome Analysis: Various Reasons of Adverse Pregnancy Outcomes Caused by Acute Toxoplasma gondii Infection

et al. 2020

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Background: Toxoplasma gondii (T. gondii) is an obligate intracellular parasite, which can affect the pregnancy outcomes in infected females by damaging the uterus, and the intrauterine environment as well as and the hypothalamus resulting in hormonal imbalance. However, the molecular mechanisms underlying the parasite-induced poor pregnancy outcomes and the key genes regulating these mechanisms remain unclear. Therefore, this study aimed to analyze the gene expression in the mouse's uterus following experimentally-induced acute infection with T. gondii RH strain. Three groups of female mice were intraperitoneally injected with tachyzoites as follow; 3 days before pregnancy (FBD6), after pregnancy (FAD6), and after implantation (FID8) as the experimental groups. Another corresponding three groups served as control, were injected with normal saline at the same time. Transcriptome analysis of the total RNA extracted from both infected and non-infected mouse uterus samples was performed using RNA sequencing (RNA-Seq).Results: The three experimental groups (FBD6, FAD6, and FID8) had a total of 4,561, 2,345, and 2,997 differentially expressed genes (DEGs) compared to the controls. The significantly upregulated and downregulated DEGs were 2,571 and 1,990 genes in FBD6, 1,042 and 1,303 genes in FAD6 and 1,162 and 1,835 genes in FID8 group, respectively. The analysis of GO annotation, and KEGG pathway showed that DEGs were mainly involved in anatomical structure development, transport, cell differentiation, embryo development, hormone biosynthetic process, signal transduction, immune system process, phagosome, pathways in cancer, and cytokine-cytokine receptor interaction pathways. Frontiers in Physiology | www.frontiersin.org February 2020 | Volume 11 | Article 115 Zhou et al. Adverse Pregnancy and T. gondii InfectionConclusion: T. gondii infection can induce global transcriptomic changes in the uterus that may cause pregnancy hypertension, destruct the intrauterine environment, and hinder the normal development of placenta and embryo. Our results may help to understand the molecular mechanisms of the acute T. gondii infection, which could promote the development of new therapeutics or prophylactics for toxoplasmosis in pregnancy.Abbreviations: CD6A, mice injected with normal saline (NS) 3 days after pregnancy; CD6B, mice injected with NS 3 days before pregnancy; CD8, mice injected with NS in the fifth day of pregnancy; DEGs, differentially expressed genes; FAD6, mice infected with T. gondii 3 days after pregnancy; FBD6, mice infected with T. gondii 3 days before pregnancy; FID8, mice infected with T. gondii on the fifth day of pregnancy.

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“…We also measured the activities of phosphoryl transfer network, Na + , K + -ATPase activity, and respiratory chain and in cerebral cortex of rats. Deficiency of these enzyme activities has been observed in some neurodegenerative diseases and patients with creatine deficiency syndromes presenting symptoms similar to those observed in patients affected by other inborn errors [36][37][38]. The hexokinase activity was not altered by sarcosine in cerebral cortex of rats.…”

Section: Discussionmentioning

confidence: 69%

Evaluation of Oxidative Stress Parameters and Energy Metabolism in Cerebral Cortex of Rats Subjected to Sarcosine Administration

et al. 2016

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Sarcosine is an N-methyl derivative of the amino acid glycine, and its elevation in tissues and physiological fluids of patients with sarcosinemia could reflect a deficient pool size of activated 1-carbon units. Sarcosinemia is a rare inherited metabolic condition associated with mental retardation. In the present study, we investigated the acute effect of sarcosine and/or creatine plus pyruvate on some parameters of oxidative stress and energy metabolism in cerebral cortex homogenates of 21-day-old Wistar rats. Acute administration of sarcosine induced oxidative stress and diminished the activities of adenylate kinase, GAPDH, complex IV, and mitochondrial and cytosolic creatine kinase. On the other hand, succinate dehydrogenase activity was enhanced in cerebral cortex of rats. Moreover, total sulfhydryl content was significantly diminished, while DCFH oxidation, TBARS content, and activities of SOD and GPx were significantly enhanced by acute administration of sarcosine. Co-administration of creatine plus pyruvate was effective in the prevention of alterations provoked by sarcosine administration on the oxidative stress and the enzymes of phosphoryltransfer network. These results indicate that acute administration of sarcosine may stimulate oxidative stress and alter the energy metabolism in cerebral cortex of rats. In case these effects also occur in humans, they may contribute, along with other mechanisms, to the neurological dysfunction of sarcosinemia, and creatine and pyruvate supplementation could be beneficial to the patients.

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Effect of histidine administration to female rats during pregnancy and lactation on enzymes activity of phosphoryltransfer network in cerebral cortex and hippocampus of the offspring

Cited by 10 publications

References 62 publications

Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori

Induced Hyperproteinemia and Its Effects on the Remodeling of Fat Bodies in Silkworm, Bombyx mori

A Transcriptome Analysis: Various Reasons of Adverse Pregnancy Outcomes Caused by Acute Toxoplasma gondii Infection

Evaluation of Oxidative Stress Parameters and Energy Metabolism in Cerebral Cortex of Rats Subjected to Sarcosine Administration

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