Effect of Histamine on Gastric Secretion

Ivy, A. C.; Bachrach, William H.

doi:10.1007/978-3-662-12016-3_14

“…However, our previous findings suggest that PGF2, is capable in stimulating gastric acid secretion in anaesthetized rats (Karppanen & Puurunen 1976). The present findings confirm these observation; after intravenous administration PGFzo stimulated gastric acid output in the same range of doses as histamine, a well-known gastric stimulant (Ivy & Bachrach 1966). In vagotomized rats the acid output was not lower than in the animals with intact vagi.…”

Section: Discussionsupporting

confidence: 91%

Stimulatory Effect of Prostaglandin F_2α on Gastric Acid Secretion in Rats

Jaatinen

¹

,

Puurunen

²

,

Karppanen

³

1988

Pharmacology & Toxicology

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The effect of intravenously administered prostaglandin F2 alpha on gastric acid secretion was investigated in anaesthetized rats. Doses of 0.03-0.3 mg/kg PGF2 alpha stimulated gastric acid output in rats with intact vagi, whereas an inhibitory effect was observed in vagotomized animals. Treatment with 5 mg/kg of Na-meclofenamate intravenously attenuated the secretory response to PGF2 alpha, while 10 mg/kg of indomethacin intravenously and 3 mg/kg of 8-phenyltheophylline intraperitoneally were without any effect. The results indicate that intravenously administered PGF2 alpha stimulates gastric acid secretion in anaesthetized rats via activation of the vagus nerve. The effects of Na-meclofenamate and indomethacin suggest that PGF2 alpha may exert its secretagogue action via specific receptors. The lack of the effect of 8-phenyltheophylline indicates that adenosine which reportedly had a similar effect on gastric secretion after intravenous injection seems not to be involved here.

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“…This increase in histamine formation could be responsible for the development of gastric ulceration because histamine has been considered as a contributing agent in the production of the aggressive acid-pepsin factor (Emmelin & Kahlson, 1944;Code, 1956Code, , 1965Kahlson, Rosengren, Svahn & Thunberg, 1964;Haverback, Stubrin & Dyce, 1965;Fischer & Snyder, 1965;Levine, 1965;Ivy & Bachrach, 1966;Beaven, Harakova, Johnson, Erjavec & Brodie, 1967). Moreover, histamine has also been thought to take part in the regulation of the gastric microcirculation (Schayer, 1962a(Schayer, , 1963(Schayer, , 1964(Schayer, , 1965(Schayer, , 1966.…”

Section: Discussionmentioning

confidence: 99%

Phenylbutazone and Histamine Formation in Rat Glandular Stomach: Its Relationship to Gastric Ulceration

Abdelgalil

¹

,

Marshall

²

1968

British Journal of Pharmacology and Chemotherapy

23

0

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“…This increase in histamine formation could be responsible for the development of gastric ulceration because histamine has been considered as a contributing agent in the production of the aggressive acid-pepsin factor (Emmelin & Kahlson, 1944;Code, 1956Code, , 1965Kahlson, Rosengren, Svahn & Thunberg, 1964;Haverback, Stubrin & Dyce, 1965;Fischer & Snyder, 1965;Levine, 1965;Ivy & Bachrach, 1966;Beaven, Harakova, Johnson, Erjavec & Brodie, 1967). Moreover, histamine has also been thought to take part in the regulation of the gastric microcirculation (Schayer, 1962a(Schayer, , 1963(Schayer, , 1964(Schayer, , 1965(Schayer, , 1966.…”

Section: Discussionmentioning

confidence: 99%