Effect of high trait anxiety on mechanical hypersensitivity in male rats

Roeska, Kerstin; Ceci, Angelo; Treede, Rolf‐Detlef; Doods, Henri

doi:10.1016/j.neulet.2009.08.031

Cited by 40 publications

(34 citation statements)

References 43 publications

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“…Using pain models such as virally induced neuropathy [27], drug-induced toxic neuropathy [27,28], nerve injury-induced neuropathy [21,23,25,34,35] or models mimicking arthritic pain [21,36,37], studies have shown that the development of pain influenced the onset of anxiety-like behaviors in rodents. The use of one or two behavioral tests in the experimental designs of these studies is, however, a salient feature to be addressed.…”

Section: Discussionmentioning

confidence: 99%

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Parent

Beaudet

Beaudry

et al. 2012

Behavioural Brain Research

119

111

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For many patients, chronic pain is often accompanied, and sometimes amplified, by co-morbidities such as anxiety and depression. Although it represents important challenges, the establishment of appropriate preclinical behavioral models contributes to drug development for treating chronic inflammatory pain and associated psychopathologies. In this study, we investigated whether rats experiencing persistent inflammatory pain induced by intraplantar injection of complete Freund's adjuvant (CFA) developed anxiety-like behaviors, and whether clinically used analgesic and anxiolytic drugs were able to reverse CFA-induced anxiety-related phenotypes. These behaviors were evaluated over 28 days in both CFA-and saline-treated groups with a variety of behavioral tests. CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: 1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), 2) a decrease in number of central squares visited in the open field (OF), and 3) a reduction in active social interactions in the social interaction test (SI). The number of entries in closed arms in the EPM and the distance travelled in the OF used as indicators of locomotor performance did not differ between treatments. Our results also reveal that in CFAtreated rats, acute administration of morphine (3 mg/kg, s.c.) abolished tactile allodynia and anxiety-like behaviors, whereas acute administration of diazepam (1 mg/kg, s.c) solely reversed anxiety-like behaviors. Therefore, pharmacological treatment of anxiety-like behaviors induced by chronic inflammatory pain can be objectively evaluated using multiple behavioral tests. Such a model could help identify/validate alternative potential targets that influence pain and cognitive dimensions of anxiety.

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Section: Discussionmentioning

confidence: 99%

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Parent

Beaudet

Beaudry

et al. 2012

Behavioural Brain Research

119

111

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“…Anxiety-related behaviors during neuropathic pain were reversed by morphine, gabapentin and duloxetine at doses that did not alter the behavioral response in pain free animals. This suggests that the suppression of pain induced an improvement in the emotional state of the animals, which in turn led to a decrease in anxiety behavior [112,203,204]. In addition, the enhanced anxiety-like behaviors during peripheral neuropathy were almost fully suppressed by imipramine, milnacipran, paroxetine and midazolam, although their effects in neuropathic sensory hypersensitivity were modest or absent [204,205].…”

Section: Pain-induced Emotional Dysfunction: Anxiety Depression and mentioning

confidence: 99%

“Bedside-to-Bench” Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes

Cobos

Portillo‐Salido

2013

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Despite the myriad promising new targets and candidate analgesics recently identified in preclinical pain studies, little translation to novel pain medications has been generated. The pain phenotype in humans involves complex behavioral alterations, including changes in daily living activities and psychological disturbances. These behavioral changes are not reflected by the outcome measures traditionally used in rodents for preclinical pain testing, which are based on reflexes evoked by sensory stimuli of different types (mechanical, thermal or chemical). These measures do not evaluate the impact of the pain experience on the global behavior or disability of the animals, and therefore only consider a limited aspect of the pain phenotype. The development of relevant new outcomes indicative of pain to increase the validity of animal models of pain has been increasingly pursued over the past few years. The aim has been to translate “bedside-to-bench” outcomes from the human pain phenotype to rodents, in order to complement traditional pain outcomes by providing a closer and more realistic measure of clinical pain in rodents. This review summarizes and discusses the most important nonstandard outcomes for pain assessment in preclinical studies. The advantages and drawbacks of these techniques are considered, and their potential impact on the validation of potential analgesics is evaluated.

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“…Whereas anxiety is a psychophysiological alarm function that signals a situational threat to integrity, pain is a psychophysiological alarm function that signals a physical threat to integrity. It has been shown even in animal experiments that, with respect to neuroperception, an additive effect takes place if both systems are activated 30,31. Neugebauer et al imply a relationship with some direct modulation by the laterocapsular division of the central nucleus of the amygdala, assuming this to be of major importance in traumatogenic pain genesis 32…”

Section: Clinical and Physiological Backgroundmentioning

confidence: 99%

Traumatization and chronic pain: a further model of interaction

Egloff¹,

Hirschi²,

Känel³

2013

JPR

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Up to 80% of patients with severe posttraumatic stress disorder are suffering from “unexplained” chronic pain. Theories about the links between traumatization and chronic pain have become the subject of increased interest over the last several years. We will give a short summary about the existing interaction models that emphasize particularly psychological and behavioral aspects of this interaction. After a synopsis of the most important psychoneurobiological mechanisms of pain in the context of traumatization, we introduce the hypermnesia–hyperarousal model, which focuses on two psychoneurobiological aspects of the physiology of learning. This hypothesis provides an answer to the hitherto open question about the origin of pain persistence and pain sensitization following a traumatic event and also provides a straightforward explanatory model for educational purposes.

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Effect of high trait anxiety on mechanical hypersensitivity in male rats

Cited by 40 publications

References 43 publications

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain

“Bedside-to-Bench” Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes

Traumatization and chronic pain: a further model of interaction

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