Effect of high‐intensity running in rectus femoris muscle fiber in rats

Díaz-Herrera, Pilar; García-Castellano, José Manuel; Torres, Ana; Morcuende, José A.; Calbet, José A. L.; Sarrat, R

doi:10.1016/s0736-0266(00)00031-0

Cited by 10 publications

(18 citation statements)

References 19 publications

(23 reference statements)

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“…With regard to muscle morphology, several previous studies have demonstrated that muscle exercise changed the composition of muscle fiber types (6), fiber size (24,25), and muscle mass (14). These results suggest that morphological changes in muscle fibers result in recovery of muscle strength.…”

Section: Muscle Fiber Composition and Lesser Diameter Of Muscle Fibermentioning

confidence: 87%

Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in normal and ovariectomized rats

et al. 2010

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Vitamin D affects not only bone but also muscle to prevent falls and osteoporotic fractures. However, these effects on muscle and the mechanisms of fall prevention are still unclear. The purpose of this study was to investigate the effects of alfacalcidol [1α(OH)D 3 ] on muscle strength, muscle fatigue, and bone mineral density (BMD) in ovariectomized rats. Seven-month-old female Wistar rats were orally administered 1α(OH)D 3 or its vehicle everyday for 4 weeks after ovariectomy (OVX) or sham operation. Calf muscle strength and fatigue were evaluated by electrical stimulation of the sciatic nerve under general anesthesia. 1α(OH)D 3 administration significantly increased the maximum muscle strength in the sham-operated (P < 0.01) and the OVX (P < 0.01) groups compared to their respective control groups. However, 1α(OH)D 3 administration did not significantly affect muscle fatigue in these groups. The BMD of the femur in the 1α(OH)D 3 -treated OVX group was significantly higher than that in the vehicle-treated OVX group (P = 0.04). These results suggested that 1α(OH)D 3 increases muscle strength but does not affect muscle fatigue in this rat model. The effectiveness of activated vitamin D in preventing bone fractures may be partly owing to its effect on muscle strength in addition to its known effect on bone metabolism.The active, hormonal form of vitamin D 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 or calcitriol] and its prodrug 1α-hydroxyvitamin D 3 [1α(OH)D 3 or alfacalcidol] have been widely used to treat a variety of metabolic bone diseases, such as rickets/osteomalacia, renal osteodystrophy, and osteoporosis (8, 41). Activated vitamin D can prevent fractures by improving bone quality, bone metabolism, and bone mineral density (BMD) (7,22,40,45,50). However, its preventive effects on fractures were more significant than its effects on bone quality or BMD. Several recent meta-analyses have demonstrated that native or activated vitamin D has preventive effects on falls (2, 16). This preventive effect on falls contributes to a partial reduction of fractures by vitamin D in elderly osteoporotic individuals (3, 37). However, the mechanisms by which activated vitamin D prevents falls remain unknown. Several factors have been reported as physical risk factors for falls, including decreased muscle strength or function of lower extremity, impaired physical function such as single-leg standing, and postural imbalance with aging (26,28,34,36). Vitamin D may act directly on muscle tissue to exert its preventive effect on falls. It has been known that osteomalacia and rickets cause muscular atrophy and decrease muscle strength and that the muscular symptoms associated with these diseases quickly improve with vitamin D treatment (39, 43). These findings indicate a potential association between vitamin D and muscle tissue. Therefore, the effects of vitamin D on muscle tissue with regard to fall prevention have been of focus in aged and osteoporotic patients. Muscle function is defined by several factors, including mu...

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Section: Muscle Fiber Composition and Lesser Diameter Of Muscle Fibermentioning

confidence: 87%

Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in normal and ovariectomized rats

et al. 2010

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“…Sections stained for ATPase activity were used to classify fibers as type I or II. Sections stained with NADH‐reductase reaction were used for a semiquantitative evaluation of oxidative capacity to confirm the fiber type (Diaz‐Herrera et al, 2001).…”

Section: Methodsmentioning

confidence: 99%

“…Immobilization is a frequently used treatment for musculoskeletal injuries despite the side‐effects of muscle cell atrophy, intramuscular fibrosis, loss of muscle extensibility, and joint movement limitation (Cooper, 1972; Herbison et al, 1978; Williams, 1988; Kannus et al, 1998a, b). Immobilization‐induced muscle atrophy includes biochemical and morphofunctional alterations of type I and type II fibers (Diaz‐Herrera et al, 2001), which indicate changes in fiber cross‐sectional area as well as fiber‐type composition, and pathological fiber alteration (Kannus et al, 1998a, b). Contracture of the joint by immobilization causes both muscle stiffness and changes in the connective tissue of the joint (Williams, 1988).…”

mentioning

confidence: 99%

“…In animal models of physical exercise, daily training at low‐ and high‐intensity and endurance training have often been used (Kasper et al, 1990; Kannus et al, 1998a, b; Diaz‐Herrera et al, 2001). The aim of this study was to examine whether physical training would promote the rate of recovery after hindlimb immobilization and whether the frequency of exercise (free cage activity, once‐, three‐, and six times‐treadmill running a week) affected the recovery of immobilization‐induced muscle atrophy and joint contracture in rats.…”

mentioning

confidence: 99%

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Different frequency treadmill running in immobilization‐induced muscle atrophy and ankle joint contracture of rats

Sakakima

Yoshida

Sakae

et al. 2004

Scandinavian Med Sci Sports

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We investigated the effects of different frequencies of treadmill running on immobilization-induced soleus and gastrocnemius muscle atrophy and ankle joint contracture in rats using morphology and histochemistry. The right ankle joint of rat was immobilized for 2 weeks. Thereafter, the rats were randomly assigned to four groups for 6 weeks of exercise under different conditions: free cage activity and free remobilization (FR), once-a-week treadmill running (lowfrequency running program (LFR)), three-time-a-week running (middle-frequency running program (MFR)), and six-time-a-week running (high-frequency running program (HFR)) groups. Two weeks of immobilization significantly reduced the cross-sectional area of soleus type I (62%, Po0.05) and type II muscle fibers (66%, Po0.05), gastrocnemius type I (78%, Po0.05) and type II muscle fibers (68%, Po0.05), and the range of ankle joint movement (46%, Po0.05). Immobilization also increased the ratio of type II to total fiber numbers in the soleus (Po0.05), and gastrocnemius (Po0.05), and induced pathological changes in muscle fibers. Some of these changes could not be corrected by free remobilization; however, the LFR, MFR, and HFR groups clearly recovered toward normal levels with exercise frequency, the effect on muscle recovery being more beneficial in the MFR and HFR groups. In addition, the range of ankle joint contracture was improved in LFR, MFR, and HFR groups in comparison with that in the FR group. These findings indicate that treadmill running exercise improved the immobilization-induced muscle fiber histochemical alterations and the range of the ankle motion in rats. Running three times and six times a week was more beneficial for recovery of immobilization-induced muscle atrophy and joint contracture compared with no running or once-a-week running.

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“…Immobilization-induced muscle atrophy involves biochemical and morphofunctional alterations of type I and type II fibers [5] , which indicate changes in fiber cross-sectional area, fiber type composition and pathological fiber alteration [4,6] . Independent of events leading to atrophy, reloading of the muscle is necessary to return to a pre-atrophy functional level.…”

Section: Introductionmentioning

confidence: 99%

Effects of Passive Stretching on Muscle Injury and HSP Expression during Recovery after Immobilization in Rats

Inoue

Suzuki²,

Hagiwara³

et al. 2009

Pathobiology

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Objective: Stretching exercise is known to induce muscle hypertrophy and is implicated in the modulation of muscle fiber behavior. We aim to determine whether stretching exercise is protective against reloading-induced muscle damage in immobilized rat soleus muscle. Methods: Rat hindlimbs in 54 eight-week-old male Wistar rats were immobilized by cast for 4 weeks, followed by reloading alone through normal ambulation in 24 (group NS) and after passive stretch in 25 rats (group S). Stretching exercise (30 min each day) lasted 6 days. To determine if passive stretching affects expression of heat shock proteins (HSPs) in rat soleus muscle during reloading following cast immobilization, the ratio of invading muscle fibers and HSPs expression were measured following cast removal. Results: The ratio of invading muscle fibers increased during the first and second days of reloading in group NS. Compared with reloading alone, stretching exercise reduced invading muscle fibers at most time points following cast removal (group S). Additionally, expression of HSP25 and HSP72 increased with time during reloading only in the group without passive stretch (group NS). Conclusion: Following immobilization, in the rat soleus muscle passive stretching exercise protects against injury induced by reloading. Furthermore, the protection provided by passive stretch is independent of HSPs.

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Effect of high‐intensity running in rectus femoris muscle fiber in rats

Cited by 10 publications

References 19 publications

Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in normal and ovariectomized rats

Effects of alfacalcidol on muscle strength, muscle fatigue, and bone mineral density in normal and ovariectomized rats

Different frequency treadmill running in immobilization‐induced muscle atrophy and ankle joint contracture of rats

Effects of Passive Stretching on Muscle Injury and HSP Expression during Recovery after Immobilization in Rats

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