Effect of high-intensity exercise on cerebral, respiratory and peripheral muscle oxygenation of HF and COPD-HF patients

Goulart, Cássia da Luz; Arêas, Guilherme Peixoto Tinoco; Caruso, Flávia Cristina Rossi; Araújo, Adriana; Moura, Sílvia Cristina Garcia de; Catai, Aparecida Maria; Beltrame, Thomas; Carvalho, Luiz Carlos de; Santos, P.B. dos; Roscani, Meliza Goi; Mendes, Renata Gonçalves; Arena, Ross; Borghi‐Silva, Audrey

doi:10.1016/j.hrtlng.2020.06.013

Cited by 6 publications

(18 citation statements)

References 28 publications

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“…The skinfold was < 12.5 mm in all patients to ensure that the amount of fat between the muscle probe did not interfere with the signals ( van der Zwaard et al, 2016 ). The light probe was placed to the belly of the vastus lateralis muscle, approximately 15 cm from the upper edge of the patella, and firmly attached to the skin using adhesive tape ( Goulart et al, 2020b ) and involved in a black closed mesh with a velcro. Briefly, one fiberoptic bundle carries the NIR light produced by the laser diodes to the tissue of interest while a second fiberoptic bundle returns the transmitted light from the tissue to a photon detector in the spectrometer.…”

Section: Methodsmentioning

confidence: 99%

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Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction

et al. 2021

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BackgroundRespiratory muscle unloading through proportional assist ventilation (PAV) may enhance leg oxygen delivery, thereby speeding off-exercise oxygen uptake (V.⁢O2) kinetics in patients with heart failure with reduced left ventricular ejection fraction (HFrEF).MethodsTen male patients (HFrEF = 26 ± 9%, age 50 ± 13 years, and body mass index 25 ± 3 kg m2) underwent two constant work rate tests at 80% peak of maximal cardiopulmonary exercise test to tolerance under PAV and sham ventilation. Post-exercise kinetics of V.⁢O2, vastus lateralis deoxyhemoglobin ([deoxy-Hb + Mb]) by near-infrared spectroscopy, and cardiac output (QT) by impedance cardiography were assessed.ResultsPAV prolonged exercise tolerance compared with sham (587 ± 390 s vs. 444 ± 296 s, respectively; p = 0.01). PAV significantly accelerated V.⁢O2 recovery (τ = 56 ± 22 s vs. 77 ± 42 s; p < 0.05), being associated with a faster decline in Δ[deoxy-Hb + Mb] and QT compared with sham (τ = 31 ± 19 s vs. 42 ± 22 s and 39 ± 22 s vs. 78 ± 46 s, p < 0.05). Faster off-exercise decrease in QT with PAV was related to longer exercise duration (r = −0.76; p < 0.05).ConclusionPAV accelerates the recovery of central hemodynamics and muscle oxygenation in HFrEF. These beneficial effects might prove useful to improve the tolerance to repeated exercise during cardiac rehabilitation.

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Section: Methodsmentioning

confidence: 99%

“…Due to the uncertainty of the differential pathlength factor (DPF) for the quadriceps, we did not use a DPF in the present study. The distance between the light emitters and the receiver was 3.5 cm ( Goulart et al, 2020b ).…”

Section: Methodsmentioning

confidence: 99%

Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction

et al. 2021

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“…(2) peak oxygen consumption ( VO 2 ) (in ml/min and mlO 2 kg −1 min −1 ); (3) carbon dioxide production VCO 2 (ml/min); (4) minute ventilation peak ( VE ) (ml/min); 5) WR (W); (6) HR at rest and peak (bpm); (7) peak peripheral oxygen saturation (SpO 2 , %); and (8) Borg dyspnea and leg effort 0-10. The VO 2 (in ml/min and mlO 2 kg −1 min −1 ), VCO 2 (ml/min), and VE (ml/min) were reported as 20-s averaged data.…”

Section: Ventilatory Metabolic Cardiac and Hemodynamic Measurementsmentioning

confidence: 99%

“…Transmitter light and receiver fiber were separated by 40 mm, corresponding to ∼20 mm of penetration depth. This method allows dynamic evaluation of relative blood concentration changes of oxyhemoglobin (OxyHb+Mb) and deoxyhemoglobin (DeoxyHb+Mb) (7).…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

“…Exercise intolerance may be directly associated with the increased ventilatory response to metabolic demand (5, 6). Goulart et al (7) found that the patients with COPD-HF have a marked exercise intolerance with greater deoxygenation of both the respiratory and peripheral musculature when compared with HF patients. Therefore, interventions aimed at improving the peripheral muscle dysfunction, unloading respiratory muscles during exercise, and local energy supply to the locomotor muscles are of great importance.…”

Section: Introductionmentioning

confidence: 99%

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Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF?

Goulart

Caruso

Araújo

et al. 2022

Front. Cardiovasc. Med.

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AimTo evaluate the effect of non-invasive positive pressure ventilation (NIPPV) on (1) metabolic, ventilatory, and hemodynamic responses; and (2) cerebral (Cox), respiratory, and peripheral oxygenation when compared with SHAM ventilation during the high-intensity exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF).Methods and ResultsOn separate days, patients performed incremental cardiopulmonary exercise testing and two constant-work rate tests receiving NIPPV or controlled ventilation (SHAM) (the bilevel mode—Astral 150) in random order until the limit of tolerance (Tlim). During exercise, oxyhemoglobin (OxyHb+Mb) and deoxyhemoglobin (DeoxyHb+Mb) were assessed using near-infrared spectroscopy (Oxymon, Artinis Medical Systems, Einsteinweg, The Netherlands). NIPPV associated with high-intensity exercise caused a significant increase in exercise tolerance, peak oxygen consumption (V·O2 in mlO2·kg−1·min−1), minute ventilation peak (V·E in ml/min), peak peripheral oxygen saturation (SpO2, %), and lactate/tlim (mmol/s) when compared with SHAM ventilation. In cerebral, respiratory, and peripheral muscles, NIPPV resulted in a lower drop in OxyHb+Mb (p < 0.05) and an improved deoxygenation response DeoxyHb+Mb (p < 0.05) from the half of the test (60% of Tlim) when compared with SHAM ventilation.ConclusionNon-invasive positive pressure ventilation during constant work-rate exercise led to providing the respiratory muscle unloading with greater oxygen supply to the peripheral muscles, reducing muscle fatigue, and sustaining longer exercise time in patients with COPD-HF.

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Cerebral oxygenation during cardiopulmonary exercise testing in cardiorespiratory diseases: A systematic review

et al. 2023

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Effect of high-intensity exercise on cerebral, respiratory and peripheral muscle oxygenation of HF and COPD-HF patients

Cited by 6 publications

References 28 publications

Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction

Proportional Assist Ventilation Improves Leg Muscle Reoxygenation After Exercise in Heart Failure With Reduced Ejection Fraction

Can Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF?

Cerebral oxygenation during cardiopulmonary exercise testing in cardiorespiratory diseases: A systematic review

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