Effect of high glucose, Porphyromonas gingivalis lipopolysaccharide and advanced glycation end‐products on production of interleukin‐6/‐8 by gingival fibroblasts

Abstract

A synergistic effect of the production of IL-8 could be induced in HGFs with the combination of high glucose, LPS and AGEs.

Advanced glycation end‐products increase IL‐6 and ICAM‐1 expression via RAGE, MAPK and NF‐κB pathways in human gingival fibroblasts

“…AGEs are known to accumulate at greater amounts in the gingival tissues of patients with DM than in those of individuals without DM . The combination of high glucose concentrations and AGEs more strongly upregulated IL‐6 production, while the combination of AGEs and P.g ‐LPS under high glucose conditions synergistically increased IL‐8 expression in HGFs . In the present study, AGEs increased IL‐6 expression in HGFs and promoted the production of IL‐6 and ROS activity in combination with P.g ‐LPS (data not shown).…”

“…When peripheral blood from patients with periodontitis and type 2 DM was stimulated with Porphyromonas gingivalis lipopolysaccharide ( P.g ‐LPS), IL‐6 levels in blood increased more than in that from individuals without DM . Chiu et al recently showed that high glucose concentrations and AGEs as well as P.g ‐LPS increased IL‐6 and IL‐8 levels in HGFs. IL‐6 is strongly expressed in periodontitis and DM and appears to play a role in the associated inflammatory responses.…”

Association of advanced glycation end products with peri‐implant inflammation in prediabetes and type 2 diabetes mellitus patients

“…6 The underlying mechanism is associated with the accumulation of continuous inflammatory response stimulated by bacterial biofilm. 8 Similar mechanisms may be implicated in the pathogenesis of tissue destruction around dental implants in T2DM and prediabetic state. 8 Similar mechanisms may be implicated in the pathogenesis of tissue destruction around dental implants in T2DM and prediabetic state.…”

Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus healthy patients: A meta‐analysis

“…The role of hyperglycemia in the pathogenesis of peri‐implant diseases has been described by several authors . Animal studies have shown that hyperglycemia has negative effects not only on bone formation but also on bone strength osseointegration and fracture healing .…”