Effect Of High-Fructose Solution On Body Weight, Body Fat, Blood Glucose And Triglyceride Levels In Rats

Sandeva, Rositsa V.; Mihaylova, Stanislava M.; Sandeva, G.; Trifonova, K.; Popova-Katsarova, Ruska D.

doi:10.1515/jbcr-2015-0143

Cited by 12 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fasting serum glucose was significantly higher in fructose control group than in normal control group (p = 0.007). This finding is in agreement with Sandeva et al's study, which reported that serum glucose level was significantly increased in male and female rats fed on 20% of fructose solution in drinking water for 8 weeks [23].…”

Section: Discussionsupporting

confidence: 93%

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

et al. 2019

View full text Add to dashboard Cite

Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high fructose diet. A post-test experimental study was conducted on a total of 30 (9-10 weeks old) male albino Wistar rats. The rats were divided into 6 groups: group I (normal control)-fed on standard chow and plain tap water only; group II (fructose control)-fed on standard chow and 20% of fructose solution; group III-VI (treatment groups)-fed on standard chow, 20% of fructose solution and treated with 71, 142, 213 and 284 mg/kg body weight/day of coffee respectively for six weeks. At the end, body weight, serum glucose, uric acid and lipid profile levels were investigated. Data was entered and cleared by epi-data software version 3.1 and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 23.00. Statistical significance was considered at p < 0.05. The results showed that body weight, fasting serum glucose and uric acid levels significantly lowered in rats treated with 213 (p = 0.047; 0.049; 0.026) and 284 (p = 0.035; 0.029; 0.010) mg/kg body weight/day of coffee compared to fructose control group. Fasting serum triglycide (TG) and low density lipoprotein (LDL-C) levels showed significant reduction in rats treated with 284 mg/kg body weight/day of coffee as compared to fructose control group (p = 0.031; 0.046) respectively. In conclusion, treating rats with coffee decreased body weight, fasting serum glucose, uric acid, TC, TG and LDL-C, and increased HDL-C in a dose dependent manner in rats feeding on high fructose diet, suggesting that coffee consumption may be helpful in ameliorating metabolic syndrome.

show abstract

Section: Discussionsupporting

confidence: 93%

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Thus, ascorbic acid may be beneficial in the treatment of obesity. However, more experimental studies are required to establish the use of ascorbic acid in obesity treatment because controversy abounds as to whether ascorbic acid is efficacious or not in inducing weight loss and lowering lipid in obese subjects [13]- [15]. Therefore, this study investigates the role of ascorbic acid in the treatment of obesity.…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity and Anti-lipidemic Properties of Ascorbic Acid in Fructose Induced Obese Wistar Rats

Fabiyi-Edebor

2020

EJMED

View full text Add to dashboard Cite

There are controversies as to whether ascorbic acid is efficacious in inducing weight loss and lowering lipid in obese subjects. Therefore, this study investigates the role of ascorbic acid in the treatment of obesity. Twenty-four male wistar rats were randomly divided into control, fructose, ascorbic acid and statin (n=6). Obesity was induced in the rats via free gavage drinking of fructose solution (20%w/v). Then, ascorbic acid group received 1g/kg/p.o ascorbic acid while statin group received 200mg/kg/p.o atorvastatin through oral canula for two weeks. The waist circumference, body weight, nose-anal length and Lee obesity index of the rats were measured using a vernier caliper, weighing balance and tape respectively. Serum Apolipoprotein A1 and B, Superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH) and ascorbic acid were determined spectrophotometrically. Analysis of variance (ANOVA) was used to analyze data at α=0.05. The significant (p<0.01) increases in waist circumference, body weight, nose-anal length, apolipoprotein B and a lee index >300 indicated that fructose induced obesity and dyslipidemia in the wistar rats. But ascorbic acid and statin decreased (p<0.05) the waist circumference, body weight, Lee index and apolipoprotein B in the obese rats. Also, serum MDA and SOD increased while glutathione and ascorbic acid decreased significantly (p<0.05) in the obese rats, however, these were reversed upon ascorbic acid and statin treatment. Thus, ascorbic acid may serve as an anti-obesity and anti-lipidemic agent via acting on oxidative stress pathway.

show abstract

“…It has contributed to the increasing epidemic of obesity and metabolic syndrome. 18 A high-fructose diet interferes with the secretion and production of neuropeptides such as ghrelin and leptin, associated with appetite control. It may stimulate the compensation system in the hypothalamus.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Angiotensin-Converting Enzyme Inhibitory Effects of Indonesian Traditional Medicine (Jamu)

2021

TJNPR

View full text Add to dashboard Cite

Hypertension represents a condition when blood pressure increase chronically. 1 It can occur because the heart works harder to adequately pump blood to meet the body's oxygen and nutritional needs. If allowed, this disease can interfere with other organs' function, especially vital organs like the heart and kidneys. 1 The prevalence of high blood pressure in Indonesia for people aged ≥ 18 years is 34.1%; the highest is in South Kalimantan (44.1%), while the lowest is in Papua (22.2%). The mortality rate due to hypertension in Indonesia is 427,218 of the 63,309,620 predicted number of cases. The percentage of hypertension based on the age group is 31.6% in the 31-44 years age group, 45.3% at the age 45-54 years, and 55.2% at the age 55-64 years. From 34.1% of hypertension sufferers, it is identified that 8.8% were diagnosed, 13.3% of hypertensive patients did not receive treatment, and 32.3% did not regularly take medicine. Many hypertensive patients do not get proper treatment because they do not know that they have hypertension. They do not take medication for several reasons; namely, the patient felt healthful (59.8%), did not regularly visit health care facilities (31.3%), used conventional medication (14.5%), handled another therapy (12.5%), skipped to receive medicine (11.5%), could not afford to buy medicine (8.1%), there were drug side effects (4.5%). Antihypertensive medicines were

show abstract

Effect Of High-Fructose Solution On Body Weight, Body Fat, Blood Glucose And Triglyceride Levels In Rats

Cited by 12 publications

References 16 publications

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

Anti-obesity and Anti-lipidemic Properties of Ascorbic Acid in Fructose Induced Obese Wistar Rats

Investigation of Angiotensin-Converting Enzyme Inhibitory Effects of Indonesian Traditional Medicine (Jamu)

Contact Info

Product

Resources

About