Effect of High-Fructose Diet on Physiological, Biochemical and Morphological Parameters of TAAR9 Knockout Female Rats

Apryatin, S A; Zhukov, Ilya S.; Manasyan, A. L.; Murtazina, Ramilya Z.; Khunagov, Temirkan A.; Lezina, A. I.; Клименко, В. М.

doi:10.1134/s0022093021050173

Cited by 1 publication

(2 citation statements)

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“…Moreover, SNARE proteins contribute to the interaction with extracellular matrix and cell-cell contacts [ 53 ]. Interestingly, it was previously demonstrated that TAAR9 expression may be related to decreased endogenous cholesterol absorption, biosynthesis, transport, or any other alterations in metabolism [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…TAAR9 is also known to be expressed at a low level in immune cells, including NK-cells, T-cells, B-cells, and monocytes [ 15 ]. TAAR1 and TAAR9 elimination in knockout rodents is associated with minor deregulation of lipid and protein metabolism [ 16 ], which becomes more pronounced under a high-carbohydrate diet [ 17 ]. Interestingly, total cholesterol and low-density lipoproteins are decreased in TAAR9-KO animals.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats

et al. 2022

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Trace amine-associated receptors (TAAR1-TAAR9) are a family of G-protein-coupled monoaminergic receptors which might have great pharmacological potential. It has now been well established that TAAR1 plays an important role in the central nervous system. Interestingly, deletion of TAAR9 in rats leads to alterations in the periphery. Previously, we found that knockout of TAAR9 in rats (TAAR9-KO rats) decreased low-density lipoprotein cholesterol levels in the blood. TAAR9 was also identified in intestinal tissues, and it is known that it responds to polyamines. To elucidate the role of TAAR9 in the intestinal epithelium, we analyzed TAAR9-co-expressed gene clusters in public data for cecum samples. As identified by gene ontology enrichment analysis, in the intestine, TAAR9 is co-expressed with genes involved in intestinal mucosa homeostasis and function, including cell organization, differentiation, and death. Additionally, TAAR9 was co-expressed with genes implicated in dopamine signaling, which may suggest a role for this receptor in the regulation of peripheral dopaminergic transmission. To further investigate how TAAR9 might be involved in colonic mucosal homeostasis, we analyzed the fecal microbiome composition in TAAR9-KO rats and their wild-type littermates. We identified a significant difference in the number of observed taxa between the microbiome of TAAR9-KO and wild-type rats. In TAAR9-KO rats, the gut microbial community became more variable compared with the wild-type rats. Furthermore, it was found that the family Saccharimonadaceae, which is one of the top 10 most abundant families in TAAR9-KO rat feces, is almost completely absent in wild-type animal fecal samples. Taken together, these data indicate a role of TAAR9 in intestinal function.

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Section: Discussionmentioning

confidence: 99%