Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Benazzouz, Abdelhamid; Gao, Dawei; Ni, Zhongge; Piallat, Brigitte; Bouali‐Benazzouz, Rabia; Benabid, Alim Louis

doi:10.1016/s0306-4522(00)00199-8

Cited by 305 publications

(212 citation statements)

References 46 publications

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“…For example, Baunez and colleagues reported that bilateral STN lesions enhance motivation for food, as measured by progressive ratio performance and conditioned place preference (Baunez et al, 2002(Baunez et al, , 2005. Furthermore, HFS of the STN, which is thought to mimic ablation of the STN by inducing depolarization block (Benazzouz et al, 1993(Benazzouz et al, , 1995(Benazzouz et al, , 2000Lozano et al, 2002) (but see Garcia et al, 2005), enhances motivation and decreases apathy and also increases the therapeutic potency of the dopamine-enhancing drug L-3,4-dihydroxyphenylalanine (L-DOPA) in patients with Parkinson's disease (Limousin et al, 1998;Houeto et al, 2002;Funkiewiez et al, 2003;Ashkan et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Subthalamic Nucleus Lesions Enhance the Psychomotor-Activating, Incentive Motivational, and Neurobiological Effects of Cocaine

Uslaner

Yang

Robinson³

2005

J. Neurosci.

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The subthalamic nucleus (STN) is traditionally thought to be involved in motor control, and dysfunction of the STN is thought to contribute to movement disorders. Here, we show that the STN also plays an important role in motivational processes and the response to drugs of abuse. Specifically, bilateral STN lesions produced a dose-dependent increase in the psychomotor-activating effects of cocaine, the rate at which animals acquired cocaine self-administration, and the motivation for cocaine assessed using a progressive ratio schedule. Furthermore, bilateral STN lesions enhanced the ability of cocaine to induce gene expression in the nucleus accumbens and caudate-putamen, two structures known to be involved in mediating the psychomotor-activating and incentive motivational effects of drugs of abuse. These findings suggest that engagement of the STN serves to dampen the psychomotor-activating and incentive motivational effects of drugs of abuse. Thus, the STN may serve as a novel target for therapeutic interventions aimed at treating drug dependence.

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Section: Discussionmentioning

confidence: 99%

Subthalamic Nucleus Lesions Enhance the Psychomotor-Activating, Incentive Motivational, and Neurobiological Effects of Cocaine

Uslaner

Yang

Robinson³

2005

J. Neurosci.

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“…7,17 Consistent with this hypothesis are several studies showing that HFS in either the subthalamic nucleus (STN) or globus pallidus pars interna (GPi) suppresses somatic activity around the stimulated electrode. [18][19][20][21][22][23][24][25][26][27] For example, Meissner et al 27 recorded STN neuronal activity for For movement disorders, deep brain stimulation is an effective therapy that, similar to surgical ablation, encompasses several therapeutic targets within the sensorimotor network. DBS targets are indicated by lightning bolts.…”

Section: Somatic Activity In the Stimulated Nucleusmentioning

confidence: 99%

Mechanisms and Targets of Deep Brain Stimulation in Movement Disorders

et al. 2008

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Summary:Chronic electrical stimulation of the brain, known as deep brain stimulation (DBS), has become a preferred surgical treatment for medication-refractory movement disorders. Despite its remarkable clinical success, the therapeutic mechanisms of DBS are still not completely understood, limiting opportunities to improve treatment efficacy and simplify selection of stimulation parameters. This review addresses three questions essential to understanding the mechanisms of DBS. 1) How does DBS affect neuronal tissue in the vicinity of the active electrode or electrodes? 2) How do these changes translate into therapeutic benefit on motor symptoms? 3) How do these effects depend on the particular site of stimulation? Early hypotheses proposed that stimulation inhibited neuronal activity at the site of stimulation, mimicking the outcome of ablative surgeries. Recent studies have challenged that view, suggesting that although somatic activity near the DBS electrode may exhibit substantial inhibition or complex modulation patterns, the output from the stimulated nucleus follows the DBS pulse train by direct axonal excitation. The intrinsic activity is thus replaced by high-frequency activity that is time-locked to the stimulus and more regular in pattern. These changes in firing pattern are thought to prevent transmission of pathologic bursting and oscillatory activity, resulting in the reduction of disease symptoms through compensatory processing of sensorimotor information. Although promising, this theory does not entirely explain why DBS improves motor symptoms at different latencies. Understanding these processes on a physiological level will be critically important if we are to reach the full potential of this powerful tool.

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“…Indeed, application of either muscimol or electrical stimulation directly in the anterior SNR is anticonvulsant, and the anterior SNR may mediate the anticonvulsant effects of STN manipulations (23,24). The mechanisms through which 130-Hz electrical stimulation of the STN may decrease the spontaneous firing rate in the SNR includes (a) depletion of glutamate in the presynaptic terminal of STN projections, (b) retrograde activation of pallidal neurons resulting in increased inhibition from the pallidum on the substantia nigra pars reticulata (SNR) and the entopeduncular nucleus, and (c) firing blockade at the STN neuron (16,25,26).…”

Section: Figmentioning

confidence: 99%

The Effect of Electrical Stimulation of the Subthalamic Nucleus on Seizures Is Frequency Dependent

2003

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Summary:Purpose: Animal studies and anecdotal human case reports have indicated that the subthalamic nucleus (STN) may be a site of anticonvulsant action.Methods: We tested the hypothesis that continuous electrical stimulation of the STN inhibits seizures acutely. We determined the effects of three stimulation frequencies, 130 Hz, 260 Hz, and 800 Hz, on generalized clonic and tonic-clonic flurothyl seizures. Adult male rats were implanted with concentric bipolar stimulating electrodes in the STN bilaterally. After recovery, rats underwent flurothyl seizures to compare the effects of each stimulation frequency on seizure threshold. Rats were tested 4 times, twice in the stimulated condition, and twice in the unstimulated condition. The order of trials was random, except that stimulation trials alternated with control trials. Flurothyl seizure thresholds under each stimulation condition were compared with control values from the same animal.Results: Bilateral stimulation of the STN at 130 Hz produced a significant increase in the seizure threshold for clonic flurothyl seizures, whereas stimulation at 260 Hz did not appear to have any effect on seizures. STN stimulation at 800 Hz significantly lowered seizure threshold for tonic-clonic seizures.Conclusions: We conclude that electrical stimulation of the STN can be anticonvulsant, but the effects appear to depend on the stimulation frequency and the type of seizure.

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Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat

Cited by 305 publications

References 46 publications

Subthalamic Nucleus Lesions Enhance the Psychomotor-Activating, Incentive Motivational, and Neurobiological Effects of Cocaine

Subthalamic Nucleus Lesions Enhance the Psychomotor-Activating, Incentive Motivational, and Neurobiological Effects of Cocaine

Mechanisms and Targets of Deep Brain Stimulation in Movement Disorders

The Effect of Electrical Stimulation of the Subthalamic Nucleus on Seizures Is Frequency Dependent

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