Effect of high flux versus low flux hemodialysis on serum beta-2 microglobulin, advanced oxidation protein products and protein carbonyl

El-Wakil, Hala S; Abou-Zeid, Abla A.; El-Gohary, Iman E; El-Seoud, Nahla A Abou; El-Yazeed, Manar A. Abou; El-Leithy, Maha A.

doi:10.1016/j.ajme.2011.04.004

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…In the same study, however, the use of low-flux membrane revealed all three indexes were significantly increased. The findings confirmed that the use of high-flux membrane will significantly better the diffusion of uremic toxins ( 22 ). This finding was consistent with our study.…”

Section: Discussionsupporting

confidence: 67%

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High-Flux and Low-Flux Membranes: Efficacy in Hemodialysis

Oshvandi¹,

Kavyannejad²,

Borzuo³

et al. 2014

Nurs Midwifery Stud

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Background: Inadequacy of dialysis is one of the main causes of death in hemodialysis patients. Some studies have suggested that highflux membrane improves the removal of moderate-sized molecules while other studies indicate no significant effect on them. Objectives: This study aimed to investigate the dialysis efficacy of low-flux versus high-flux membranes in hemodialysis patients. Patients and Methods: Forty hemodialysis patients participated in this cross-over clinical trial. Two sessions of low-flux and high-flux membrane dialysis were performed consecutively, in the first and second stage of the trial. In both stages, blood samples before and after the dialysis were taken and sent to the laboratory for assessment. Blood urea nitrogen (BUN), KT/V and the urea reduction ratio (URR) indexes were used to determine dialysis efficacy. Data were analyzed using t test and paired t test. Results: The mean KT/V was 1.27 ± 0.28 in high-flux and 1.10 ± 0.32 in low-flux membrane which, these differences were statistically significant (P = 0.017). The mean of URR was 0.65 ± 0.09 in high-flux and 0.61 ± 0.14 in low-flux membrane, which these differences were not statistically significant (P = 0.221). Conclusions:The high-flux membrane had better dialysis adequacy, so we suggest using high-flux membrane in hemodialysis centers.

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Section: Discussionsupporting

confidence: 67%

“…UF is the ultrafiltration per liter and T is the time of dialysis per hour. URR is estimated based on this formula: URR = (urea pre-dialysis - urea post-dialysis)/urea pre-dialysis x100 ( 20 - 22 ).…”

Section: Methodsmentioning

confidence: 99%

High-Flux and Low-Flux Membranes: Efficacy in Hemodialysis

Oshvandi¹,

Kavyannejad²,

Borzuo³

et al. 2014

Nurs Midwifery Stud

View full text Add to dashboard Cite

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“…It was shown by El-Wakil et al that high-flux membranes are more efficient in removing middle molecules like beta-two microglobulin as compared to low-flux membranes. 11 Another study showed that variations in materials and the general structure of the dialyzer could affect protein loss. However, differences in the pore size of the dialyzer do not have a large effect.…”

Section: Discussionmentioning

confidence: 99%

Effect of Different Dialysis Membranes on Protein Loss During Hemodialysis

Mir

Raja

Azam

et al. 2023

PAFMJ

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Objective: To compare the loss of proteins with high and low flux hemodialysis membranes. Study Design: Cross-sectional analytical study. Place and Duration of Study: Department of Nephrology, Pak Emirates Military Hospital, Rawalpindi Pakistan, from Nov 2019 to Feb 2020. Methodology: This study was conducted on patients with end-stage renal disease on maintenance haemodialysis. We excluded patients on haemodialysis for less than one month, those with poor compliance to hemodialysis, those undergoing hemodialysis for less than four hours per session and unwilling patients. Patients were divided into two groups: one was dialyzed with high flux membranes, whereas low flux membranes were used for the other group. Dialysate samples were collected during the first hour and then during the last hour of each haemodialysis session to estimate protein losses in each group. Results: Data were recorded during 133 hemodialysis sessions, the patients underwent. There were 22 patients, including 12 (54.55%) males, having a mean age of 46.45±13.99 years. Most patients (17, 77.27%) were on twice-a-week dialysis, whereas the rest were dialyzed thrice weekly. Protein loss was 0.45± 0.23g/L with low flux membranes and 1.20±0.60g/L with high flux membranes. This difference was statistically significant (p= <0.001). Conclusion: High flux dialysis membranes are associated with greater protein loss during hemodialysis.

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