Effect of high-fiber diet on plasma high density lipoprotein (HDL) cholesterol level in streptozotocin-induced diabetic rats.

Yamashita, Sono; Yamashita, Kamejiro

doi:10.1507/endocrj1954.27.671

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…Our data confirm previous reports in the literature 1020 " 25 which examined the addition of various dietary fibers in which specific attention to the soluble or insoluble character of the fiber was not identified as a potential factor in predicting the metabolic response of rats to the diet. Considering the 18 groups of animals fed differing fiber-supplemented diets, it is clear that those fibers that are predominantly soluble (such as pectin, gum guar, carrageenan, or oat bran) are regularly associated with a reduction in both plasma and hepatic cholesterol concentrations, and a rise in plasma HDL.…”

Section: ^25supporting

confidence: 90%

“…1020 " 25 The present investigation was designed to examine the theory that eating fiber enriched in water-soluble, mucilaginous materials may selectively result in these cholesterol-lowering effects. Our data are consistent with the concept that plasma low density lipoprotein may be reduced by the dietary addition of pectin fiber which contains soluble components.…”

Section: Discussionmentioning

confidence: 99%

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Dietary fiber and lipoprotein metabolism in the genetically obese Zucker rat.

Wilson¹,

S²,

Eaton³

1984

Arteriosclerosis

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The present investigation was designed to examine the influence of dietary fibers with differing soluble fiber compositions upon the metabolism of lipids in a hyperlipemic animal model, the Zucker fatty rat. The response to fiber was examined using a diet supplemented with cellulose, oat bran, or pectin which have a soluble/insoluble fiber ratio of 0:100, 33=66, and 100=0, respectively. These fibers provided 10% of the total diet weight; the control diet contained no fiber. A rapid increase in plasma triglyceride concentration was observed in all animals given fiber-supplemented diets in correlation with the increased carbohydrate content of the defined diets relative to the prestudy diets. This increase in plasma triglyceride was due to increased production of triglycerides with no change in the rates of clearance. The plasma total cholesterol levels were relatively constant on all diets. However, after 7 weeks on the pectinsupplemented diet, rats showed a 39% elevation in HDL and a 44% reduction in LDL concentration. This diet also resulted in reduced weight gain, in spite of a caloric intake equivalent to the control diets. Our data suggest that the ability of dietary fiber to alter plasma lipoproteins might be predictable from the soluble fiber composition or the pectin content of a given dietary fiber in this model of genetic endogenous hyperlipemia. (Arteriosclerosis

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Section: ^25supporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Dietary fiber and lipoprotein metabolism in the genetically obese Zucker rat.

Wilson¹,

S²,

Eaton³

1984

Arteriosclerosis

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“…A higher cellulose diet (10 g/100 g diet) was been shown to alleviate hyperglycemia in diabetic rats. ( 24 ) Our okara diet contained smaller amounts of active ingredients (isoflavones, β-conglycinin, and fiber) than previously tested diets. Nevertheless, the combination of these ingredients may have had synergistic or additive effects on improving glucose tolerance.…”

Section: Discussionmentioning

confidence: 91%

Okara ameliorates glucose tolerance in GK rats

Hosokawa

Katsukawa

Tanaka

et al. 2016

J. Clin. Biochem. Nutr.

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Okara, a food by-product from the production of tofu and soy milk, is rich in three beneficial components: insoluble dietary fiber, β-conglycinin, and isoflavones. Although isoflavones and β-conglycinin have recently been shown to improve glucose tolerance, the effects of okara have not yet been elucidated. Therefore, we herein investigated the effects of okara on glucose tolerance in Goto-Kakizaki (GK) rats, a representative animal model of Japanese type 2 diabetes. Male GK rats were fed a 10% lard diet with or without 5% dry okara powder for 2 weeks and an oral glucose tolerance test was performed. Rats were then fed each diet for another week and sacrificed. The expression of genes that are the master regulators of glucose metabolism in adipose tissue was subsequently examined. No significant differences were observed in body weight gain or food intake between the two groups of GK rats. In the oral glucose tolerance test, increases in plasma glucose levels were suppressed by the okara diet. The mRNA expression levels of PPARγ, adiponectin, and GLUT4, which up-regulate the effects of insulin, were increased in epididymal adipose tissue by the okara diet. These results suggest that okara provides a useful means for treating type 2 diabetes.

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“…Increased intake of non-digestible plant material in the dietary fibre could also have a beneficial effect on atherosclerosis development and cardiovascular health [ 572 ]. Among others, the observed increase in HDL cholesterol and HDL to TC levels ratio by fibre from animal [ 573 ] and human [ 574 ] studies could contribute to this protective activity. The effect of more nutraceuticals on atherosclerosis in numerous cohort studies, clinical trials, and epidemiological studies was in more detail summarised elsewhere [ 575 ].…”

Section: Currently Available Hdl-targeted Therapiesmentioning

confidence: 99%

Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies

2022

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Chronic inflammatory diseases, such as rheumatoid arthritis, steatohepatitis, periodontitis, chronic kidney disease, and others are associated with an increased risk of atherosclerotic cardiovascular disease, which persists even after accounting for traditional cardiac risk factors. The common factor linking these diseases to accelerated atherosclerosis is chronic systemic low-grade inflammation triggering changes in lipoprotein structure and metabolism. HDL, an independent marker of cardiovascular risk, is a lipoprotein particle with numerous important anti-atherogenic properties. Besides the essential role in reverse cholesterol transport, HDL possesses antioxidative, anti-inflammatory, antiapoptotic, and antithrombotic properties. Inflammation and inflammation-associated pathologies can cause modifications in HDL’s proteome and lipidome, transforming HDL from atheroprotective into a pro-atherosclerotic lipoprotein. Therefore, a simple increase in HDL concentration in patients with inflammatory diseases has not led to the desired anti-atherogenic outcome. In this review, the functions of individual protein components of HDL, rendering them either anti-inflammatory or pro-inflammatory are described in detail. Alterations of HDL proteome (such as replacing atheroprotective proteins by pro-inflammatory proteins, or posttranslational modifications) in patients with chronic inflammatory diseases and their impact on cardiovascular health are discussed. Finally, molecular, and clinical aspects of HDL-targeted therapies, including those used in therapeutical practice, drugs in clinical trials, and experimental drugs are comprehensively summarised.

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Effect of high-fiber diet on plasma high density lipoprotein (HDL) cholesterol level in streptozotocin-induced diabetic rats.

Cited by 6 publications

References 7 publications

Dietary fiber and lipoprotein metabolism in the genetically obese Zucker rat.

Dietary fiber and lipoprotein metabolism in the genetically obese Zucker rat.

Okara ameliorates glucose tolerance in GK rats

Alterations of HDL’s to piHDL’s Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies

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