Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression

Rippe, Catarina; Berger, Karin; Böiers, Charlotta; Ricquier, Daniel; Erlanson–Albertsson, Charlotte

doi:10.1152/ajpendo.2000.279.2.e293

Cited by 70 publications

(82 citation statements)

References 39 publications

(44 reference statements)

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“…Consistent with previous reports, the levels of UCP1 mRNA continued to rise (18,19). The additional increase in UCP1 expression did not prevent weight gain and glucose intolerance, which is in agreement with Margareto et al (31).…”

Section: Discussionsupporting

confidence: 92%

“…In these studies, colipase expression was found to increase in response to a diet with a higher protein content (10,28). Colipase expression has also been shown to be sensitive to surrounding temperature, being maximally expressed at 5°C (19,30). Clearly, the genes encoding lipase and colipase are not coordinately regulated since they respond differently to high-fat diets, dietary protein, and temperature.…”

Section: Discussionmentioning

confidence: 99%

“…The probes for UCP1 and UCP2 as well as for mouse pancreatic lipase, PLRP1, and PLRP2 have been described previously (14,19). The 18S rRNA probe was purchased from DNA Technology (Denmark).…”

Section: Probesmentioning

confidence: 99%

“…This results in increased heat production and decreased ATP production (16). UCP1 has been shown to increase during high-fat feeding, thereby contributing to diet-induced non-shivering thermogenesis and protecting against obesity (17)(18)(19). Uncoupling protein 2 (UCP2) is a protein with 59% sequence homology to UCP1, which has also been suggested to be involved in the defense against obesity and type 2 diabetes, based on reports of an increased expression during highfat feeding (18,20).…”

mentioning

confidence: 99%

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Effect of Long-term High-Fat Feeding on the Expression of Pancreatic Lipases and Adipose Tissue Uncoupling Proteins in Mice

Rippe

Berger

Mei³

et al. 2003

Pancreas

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Probesmentioning

confidence: 99%

mentioning

confidence: 99%

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Effect of Long-term High-Fat Feeding on the Expression of Pancreatic Lipases and Adipose Tissue Uncoupling Proteins in Mice

Rippe

Berger

Mei³

et al. 2003

Pancreas

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“…The vitamins were added to water bottles at a concentration of 1 g/liter and replaced daily (21). The diet containing enterostatin was prepared as described earlier (22).…”

Section: Targeting Construct and Generation Of Mice With Null Allele Formentioning

confidence: 99%

Decreased Postnatal Survival and Altered Body Weight Regulation in Procolipase-deficient Mice

D’Agostino¹,

Cordle²,

Kullman³

et al. 2002

Journal of Biological Chemistry

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In vitro, pancreatic triglyceride lipase requires colipase to restore activity in the presence of inhibitors, like bile acids. Presumably, colipase performs the same function in vivo, but little data supports that notion. Other studies suggest that colipase or its proform, procolipase, may have additional functions in appetite regulation or in fat digestion during the newborn period when pancreatic triglyceride lipase is not expressed. To identify the physiological role of procolipase, we created a mouse model of procolipase deficiency. The Clps ؊/؊ mice appeared normal at birth, but unexpectedly 60% died within the first 2 weeks of life. The survivors had fat malabsorption as newborns and as adults, but only when fed a high fat diet. On a low fat diet, the Clps ؊/؊ mice did not have steatorrhea. The Clps ؊/؊ pups had impaired weight gain and weighed 30% less than Clps ؉/؉ or Clps ؉/؊ littermates. After weaning, the Clps ؊/؊ mice had normal rate of weight gain, but they maintained a reduced body weight compared with normal littermates even on a low fat diet. Despite the reduced body weight, the Clps ؊/؊ mice had a normal body temperature. To maintain their weight gain in the presence of steatorrhea, the Clps ؊/؊ mice had hyperphagia on a high fat diet. Clps ؊/؊ mice had normal intake on a low fat diet. We conclude that, in addition to its critical role in fat digestion, procolipase has essential functions in postnatal development and in regulating body weight set point.

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Of mice and men – environmental temperature, body temperature, and treatment of obesity

Reitman

2018

FEBS Letters

104

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Mice are widely used for exploring obesity physiology and treatment. However, thermal biology is different between small and large mammals. In this Review, we discuss how the effect of environmental temperature must be understood to ensure applicability of mouse experiments to human obesity. At ambient environmental temperature (~ 22 °C), over one-third of energy expenditure in mice is devoted to maintaining core body temperature, largely by brown adipose tissue. To conserve this energy, mice can enter a regulated hypothermia, while humans do not. Since humans expend little or no energy specifically to keep warm, mice studied at thermoneutrality (~ 30 °C) may be a better model for human energy homeostasis. Studies indicate that environmental temperature also affects the efficacy of drugs that increase energy expenditure. In mice, dinitrophenol, a protonophore, and CL316243, a β3-adrenergic agonist, both increase metabolic rate at thermoneutrality, but only CL316243 increases it at 22 °C. Furthermore, mice housed at thermoneutrality may become more obese than mice at 22 °C. Thus, we discuss the importance of studying mice at both thermoneutrality and at lower temperatures in obesity research.

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Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression

Cited by 70 publications

References 39 publications

Effect of Long-term High-Fat Feeding on the Expression of Pancreatic Lipases and Adipose Tissue Uncoupling Proteins in Mice

Effect of Long-term High-Fat Feeding on the Expression of Pancreatic Lipases and Adipose Tissue Uncoupling Proteins in Mice

Decreased Postnatal Survival and Altered Body Weight Regulation in Procolipase-deficient Mice

Of mice and men – environmental temperature, body temperature, and treatment of obesity

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