Effect of High-fat Diet-induced Disorders on Rat with Endometrial Hyperplasia and Adiponectin System in Circulation and Uterus

Shang, Chenguang; Liu, Zhaohui; Wang, Xiaohui; Feng, Zong-Hao; Zhang, Yan

doi:10.4103/0366-6999.211551

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…These results were corroborated by a recent work of Shang, Liu, Wang, Feng, and Zhan () who reported a significant increase in the endometrial thickness as well as hyperplasia of epithelial lining cells in rats fed on high fat diet for 40 weeks. It was hence plausible that this hyperplasic profile of endometrial epithelium would be mutagenic if prolonged over a long period of time.…”

Section: Discussionsupporting

confidence: 86%

Dietary supplementation of barley and/or dates attenuate hypercholesterolemic‐induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity

et al. 2019

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Our study was conducted to characterize the efficacy of barley and/or date palm fruits (10%) in alleviation of hypercholesterolemic endometrial insults in obese rat model. Sixty‐four Wistar albino rats were randomized into eight groups (n = 8); control, hypercholesterolemic‐ and hypercholesterolemic‐treated groups. Animals were subjected to treatment for 4 months. After sacrifice, serum and uterine tissues were collected and processed for biochemical, histological, immunohistochemical, and electron microscopic investigations. In hypercholesterolemic rats, the endometrium displayed hyperplasia with necrotic patches in the surface epithelium and its glandular lining cells. Also, there was a remarkable increase in the endometrial thickness and significant decrease in corresponding glandular numbers. Prompted by these findings, immunohistochemical localization revealed that expression of proliferating cell nuclear antigen was downregulated, while cleaved caspase‐3 was upregulated in the endometrial cells in hypercholesterolemic group. Accordingly, there was remarkable depletion of antioxidant enzymatic activities associated with increased lipid peroxidation and apoptotic markers. Contradictory, supplementation of barley and/or dates to hypercholesterolemic groups showed intriguing amelioration for the histological architecture of the endometrium and balancing its oxidative redox. In conclusion, the administration of barley and/or dates confers enhanced synergistic effects in attenuation of hypercholesterolemic induced‐endometrial dysfunction. This is clear evidence that endometrial amelioration was directly linked to the implication of highly potential antioxidant capacity of barley and/or dates phytochemicals, β‐glucan, polyphenols, and other trace elements, which can be utilized to establish a phyto‐therapeutic strategy for activating endometrial cell regeneration. Practical applications Barley and dates confer both hypoglycemic and hypocholesterolemic potentials. Therefore, their ingredients would be implicated in the amelioration of uterine functions in obese women. These favorable potentials were directly linked to the restraining of endometrial inflammation and retrieving the oxidative capacity. Furthermore, our findings demonstrated that barley and dates substantially diminished the expression of TNF‐α, mitigated DNA damage and prevented leukocytic infiltration in the endometrial tissue; based on their high content of dietary phytochemicals, β‐glucan, polyphenols, and other trace elements.

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Section: Discussionsupporting

confidence: 86%

Dietary supplementation of barley and/or dates attenuate hypercholesterolemic‐induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity

et al. 2019

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“…Several factors such as a gland/stroma ratio, the presence/absence of nuclear atypia, a high nuclear cytoplasmic ratio are examined in the evaluation/classification of the presence of endometrial hyperplasia in human-derived preparations [ 34 , 35 ]. However, our study was a rat study, and the histopathological evaluation of the preparations was performed by epithelial cell height and luminal epithelial cell height measurements based on the previous studies reported [ 15 , 36 , 37 , 38 , 39 , 40 ]. In our opinion, this evaluation gave us quantitative data creating the opportunity for statistical comparisons in the experimental models.…”

Section: Discussionmentioning

confidence: 99%

Effects of melatonin on uterine hypertrophy/hyperplasia: A preliminary experimental rat study

Sivas

Tapisiz

Ayik

et al. 2020

Heliyon

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Endometrial hyperplasia is a process of endometrial proliferation that results in a thickening of the endometrial tissue. Melatonin might be able to change the pathophysiological process and prognosis into a positive way that might prevent and heal endometrial hyperplasia, which is the first stage of endometrial cancer. For this perspective, we tried to investigate the effect of melatonin on uterine hypertrophy/hyperplasia in an experimental rat model. Forty Wistar-Albino rats were undergone bilateral oophorectomy and randomized into four groups. To create a model of uterine hypertrophy/hyperplasia in all groups, except the control group [C] (n = 10), 4 mg/kg/day estradiol hemihydrate were given for 14 days. The uterine hypertrophy/hyperplasia was evaluated histopathologically in the left uterine horns, then the groups were treated for 14 days as follows; melatonin (10 mg/kg/day/po) [M] (n = 10), melatonin + estradiol hemihydrate (10 mg/kg/day/po and 4 mg/kg/day/po) [M + E] (n = 10), and dark environment [D] (n = 10). Finally, the effects of the melatonin were examined histopathologically in the right uterine horns. An uterine hypertrophy/hyperplasia model was established in all groups compared to the control group (p < 0.05). In the [M] and [M + E] groups, epithelial cell height and luminal epithelial cell height significantly decreased (41μm vs 12μm, p = 0.005; 14μm vs 10μm, p = 0.005, respectively for [M] group) and (32μm vs 14μm, p = 0.012; 17μm vs 10μm, p = 0.017, respectively for [M + E] group). The [D] group exhibited a significant decrease in epithelial cell height (33μm vs 20μm, p = 0.017). With or without estrogen exposure, melatonin-treated and physiologically melatonin-released rats experienced a significant uterine hypertrophy/hyperplasia recovery. Melatonin may have protective effects on endometrial hyperplasia.

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“…Adiponectin is an adipokine that was shown to be a risk factor for endometrial cancer [66]. Shang et al built a rat model with insulin resistance (IR) and endometrial hyperplasia (EH) and analyzed morphological effects induced in the rat uterus after high-fat diet (HFD) feeding and estrogen treatment [67]. The uterine adiponectin gene and protein levels in the HFD-estradiol group were higher than those in the HFD group.…”

Section: Endometrial Cancermentioning

confidence: 99%

The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers

Koshiyama

2019

Healthcare

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The contribution of diet to cancer risk has been considered to be higher in advanced countries than in developing countries. In this paper, I review the current issues (a review of the relevant literature), and the effects of the dietary and nutrient intake on three types of gynecologic cancer (cervical, endometrial and ovarian cancers). In cervical cancer, the most important roles of diet/nutrition in relation to cancer are prophylaxis and countermeasures against human papillomavirus (HPV) infection. The main preventive and reductive factors of cervical cancer are antioxidants, such as vitamin A, C, D and E, carotenoids, vegetables and fruits. These antioxidants may have different abilities to intervene in the natural history of diseases associated with HPV infection. For endometrial cancer, the increase in peripheral estrogens as a result of the aromatization of androgens to estrogens in adipose tissue in obese women and insulin resistance are risk factors. Thus, we must mainly take care to avoid the continuous intake of fat energy and sugar. In ovarian cancer, the etiology has not been fully understood. To the best of our knowledge, the long-term consumption of pro-inflammatory foods, including saturated fat, carbohydrates and animal proteins is a risk factor. The intake of acrylamide is also a risk factor for both endometrial and ovarian cancer. Most papers have been epidemiological studies. Thus, further research using in vitro and in vivo approaches is needed to clarify the effects of the dietary and nutrient intake in detail.

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Effect of High-fat Diet-induced Disorders on Rat with Endometrial Hyperplasia and Adiponectin System in Circulation and Uterus

Cited by 10 publications

References 30 publications

Dietary supplementation of barley and/or dates attenuate hypercholesterolemic‐induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity

Dietary supplementation of barley and/or dates attenuate hypercholesterolemic‐induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity

Effects of melatonin on uterine hypertrophy/hyperplasia: A preliminary experimental rat study

The Effects of the Dietary and Nutrient Intake on Gynecologic Cancers

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