Effect of high-dose progesterone on the pre-menstrual syndrome; a double-blind cross-over trial

Abstract

ReferencesI PERSKY M, O'BRIAN CP, KHAN MA: Reproductive hormone levels, sexual activity and moods during the menstrual cycle. Psychosom Med 38:62, 1976 z ABPLANALP JM, DONELLY AF, ROSE RM: Psychoendocrinology of the menstrual cycle. Psychmom Med 41587, I979 Mood and the menstrual cycle. Unpublished manuscript, 1981 4 DENNERSEIN L, ABRAHAM SF: Affective changes and the menstrual cycle. In: Handbook ofpsychiaw and endocrinology, PJV Beumont and GD Burrows (eds). Amsterdam, Elsevier, pp 367-400, 1982 Sexual arousability and the menstrual cycle. Psychosom Med 43:1gg, 1981 6 RUBLE D, BROOKSCUNN D: Menstrual symptoms: a social cognition analysis. J Behav Med 2:171, 1979 Menstrual cycle as focus of study and self-reports of mood and behaviour. Motiv and Emot 2:75, 1978 8 PARLEE MB: Changes in moods and activation levels 3 SANDERS D, WARNER P, BACKSTROM T, BANCROFT J: 5 SCHWNER-ENGEL P, SCHIAVX RC, SMITH H, WHlTE D: 7 ENGLANDER-GOLDEN P, WHITMORE MR, DIENSTBIER RA: during the menstrual cycle in experimentally naive subjects. In: The menstrualcycle (Vol I), AJ Dan, EA Graham and CP Beecher (eds). New York, Springer, pp 247-263, 1980 g ROSSI AS: Mood cycles by menstrual month and social week. In: Themenstrualcycle (Vol. I), AJ Dan, EA Graham, CP Beecher (eds). New York, Springer, pp 10 KRUSE JA, GOITMANN JM: Time series methodology in the study of sexual hormonal and behavioural cycles. Arch Sex Behav I I 405, 1982 I I WIEUND BA, MEFFERD RB: Identification of periodic components in physiological measurements. Psychophysiology 6:160, 19% form of electrolyte abnormalities or hepatic or renal function disturbances, were not seen. In this trial, progesterone 200 mg twice daily by the rectal route was not more effective than the placebo. J Psychosom Obstet Gynaecol Downloaded from informahealthcare.com by McMaster University on 11/03/14 For personal use only. There are no significant differences in the mean values for oestradiol, prolactin, FSH, and LH. The Journal of Psychosomatic Obstetrics and Gynaecology, 2-4 (1983) 221 J Psychosom Obstet Gynaecol Downloaded from informahealthcare.com by McMaster University on 11/03/14 For personal use only. SAMSON G: Premenstrual syndrome: a double-blind controlled trial of progesterone and placebo. Br J Psychiarr 135:2og, 1979 EW, BENEDEK-JASZMANN u: Plasma progesterone concentrations after high-dose suppositories. A preliminary report. Pharm Weekbl (Sci Ed) 4:135, 1982 BENEDEK-JASZMANN u: The premenstrual syndrome. J Drug Res 6361, ~wg I983 MEER YG VAN DER, LOENEN AC VAN, LOENDERSLOOT 222 Journal of Psychosomatic Obstetrics and Gynaecology, 2-4 (1983) J Psychosom Obstet Gynaecol Downloaded from informahealthcare.com by McMaster University on 11/03/14 For personal use only.

Efficacy of progesterone and progestogens in management of premenstrual syndrome: systematic review

“…Figure 1 shows the individual standardised mean difference for each trial, the type of preparation and dosage for that trial, and the pooled standardised mean difference with 95% confidence intervals for trials that used progesterone suppositories and those that used oral micronised progesterone. The inclusion of the data from the two low quality trials 25 26 did not significantly affect the overall result.…”

“…On our quality score four of the 10 progesterone trials 20 22 23 28 and two of the three progestogen trials 30 31 scored 6, five progesterone trials 16 – 18 21 25 and the other progestogen trial32 scored 7, and one trial of progesterone scored the maximum of 8 9…”

Premenstrual Syndrome

“…In seven studies there was no attempt to measure different types of premenstrual symptom, to allow assessment of differential treatment effects. Twelve studies used a double blind cross-over design, but in only five was the design, according to the description, methodologically adequate (Abraham & Hargrove, 1980;Andersen e l al., 1977;Mattson & von Schoultz, 1974;Sampson, 1979;Van der Meer et al, 1983) and only two studies were analysed for order or carry over effects (Abraham & Hargrove, 1980;Sampson. 1979).…”

Premenstrual symptoms and ovarian hormones: A review

“…However, placebo-controlled double-blind crossover trials have failed to support this (e.g. Jordheim, 1972;Williams et al, 1983;Dennerstein et al, 1986;Kerr et al, 1980;Sampson, 1979;van der Meer et al, 1983;Maddocks et al, 1986). The only exception is a study by Dennerstein et aL (1985) in which oral micronized progesterone was assessed and some beneficial effects were seen.…”