Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia

Kavurgacı, Suna; Melahat, Uzel Şener; YILDIZ>, Murat; Figen, Öztürk Ergür; Öztürk, Ayperi

doi:10.1016/j.medcle.2021.04.027

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Between those patients receiving vitamin C injections and those not receiving, a retrospective study by Suna et al [22] found not a significant difference in the mortality rates, the need for advanced oxygen support, intensive care, readmission rate, and stay in the hospital. Likewise, no significant benefit was found for the patients by the mendelian randomization study of vitamin C for treating the patients of COVID-19 by Hui et al [23]…”

Section: Progress In Clinical Researchmentioning

confidence: 96%

Effect and application of vitamin C on Immune function during the COVID-19 pandemic

2023

TNS

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To present a fresh idea for the COVID-19 treatment, the vitamin C influence on the immunity of the novel coronavirus was studied, by browsing through the pertinent literature. Using keywords such as "vitamin C", "COVID-19", "nutrition" and "immunity", Chinese and English searches were conducted in PubMed, Google Scholar, CNKI, Wanfang Medical, and other databases to analyze and summarize the vitamin C immune effect on the epidemic situation of COVID-19. In the treatment of COVID-19 patients, it could be concluded that vitamin C could have a certain positive influence, but the specific mechanism, the best use time, and the correct dose still need to be studied

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Section: Progress In Clinical Researchmentioning

confidence: 96%

Effect and application of vitamin C on Immune function during the COVID-19 pandemic

2023

TNS

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“…However, in clinical trials, where vitamin C has been investigated as an intervention for COVID-19, the results have not been encouraging. [12,[21][22][23][24] Much of the hype and hope surrounding free radicals and reactive oxygen species (ROS) stems from the article Aging: A Theory Based on Free Radical and Radiation Chemistry by Denham Harman. [8] Harman's paper is a landmark publication articulating the potential reactivity of ROS, however, it describes what reactions ROS can participate in but this does not necessarily translate into what reactions take place in vivo.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Antioxidant Therapies for COVID‐19

Holt,

Davies

2023

Advcd Theory and Sims

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Oxidative stress and inflammation are observed in critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). As oxidative stress is due to free radicals, free radical scavenging agents, such as vitamin C, are used in the hope of mitigating the severity of COVID‐19. In this paper an analytical model of free radical encounters within a cell is derived. It computes the effectiveness of free radical scavenging and the subsequent reduction in oxidative damage due to therapeutic intervention of exogenous antioxidants. Various publications make claims of success, albeit modest, treating critically ill COVID‐19 patients with high doses of vitamin C. The findings cast doubt on these claims and challenge the notion that any benefits attributed to vitamin C are due to free radical scavenging.

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Impacts of vitamin C and D supplement on COVID-19 treatment: possible patho-mechanisms and evidence from different countries

et al. 2023

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Background A balanced diet and nutrition greatly influence our immune system’s ability and regulate the risk and severity of infections. This review presented the possible patho-mechanisms of vitamins C and D in COVID-19 immunity. Main body Deregulation of the immune system including the decreased level of immune boosters is invariably reported in COVID-19. Vitamin C and vitamin D are among the immune boosters; homeostasis of those was found essential for fighting against the viruses, and COVID-19 is no exception. Statistical data strengthens the statements put forth on the effects of these vitamins regarding the complications, symptoms, and mortality. Short conclusion A comprehensive literature review revealed that vitamin C helps to reduce and in some cases eradicate the particular symptoms that pose major risks of COVID-19 while balanced vitamin D content in COVID-19 patients has been proved to possess a negative correlation with mortality.

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Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia

Cited by 3 publications

References 18 publications

Effect and application of vitamin C on Immune function during the COVID-19 pandemic

Effect and application of vitamin C on Immune function during the COVID-19 pandemic

An Analysis of Antioxidant Therapies for COVID‐19

Impacts of vitamin C and D supplement on COVID-19 treatment: possible patho-mechanisms and evidence from different countries

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