Effect of high-dose intravenous ascorbic acid on cancer patients following ketogenic diet

Sebastian, Stelvin; Paul, Aby; Joby, Joel; Saijan, Sanjo; Vilapurathu, Jobin Kunjumon

doi:10.4103/jcrt.jcrt_973_19

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Studies in adults with cancer using IVC have found reductions in several inflammatory markers, including C-reactive protein, erythrocyte sedimentation rate, 19,20 neutrophil-to-lymphocyte ratio, 21 and F2-isoprostanes. 22 This is particularly important and highlights an indication for use of IVC in cancer settings, given that those with cancer are documented to have increased inflammation.…”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

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Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners

Conte,

Rizzolo,

Flower

et al. 2024

CANDJ

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Intravenous vitamin C (IVC) is a common therapy used by naturopathic doctors and other licensed integrative practitioners. With several proposed mechanisms of action related to cancer care, it is often used in integrative oncology settings. Despite its common use, there are no published evidence-based resources on the efficacy, safety, and procedural considerations for the use of IVC in practice. The objectives of this review are to summarize the evidence on high-dose IVC in supportive cancer care and to provide a resource of practical clinical guidance for IVC application. In cancer care, IVC is most commonly used at doses high enough to achieve a potential cancer cell cytotoxicity. This review focuses on IVC at doses of ≥15 g which we have defined as high-dose. To date, there are 23 published clinical trials evaluating the use of high-dose IVC in cancer support. Based on data from these clinical studies, IVC used concurrently with oxidative therapies, such as chemotherapy and radiotherapy, seems to produce the greatest likelihood for improvements in quality of life and additive anti-tumour effects compared with IVC as monotherapy or with non-oxidative therapies. IVC has shown promise in improving quality of life in patients with breast cancer and advanced pancreatic and ovarian cancers. Limited evidence suggests survival and/or tumour response may be improved with the inclusion of IVC in patients with advanced pancreatic cancer, non-small cell lung cancer, and RAS-mutated colorectal cancer. IVC does not offer curative potential, and further research is needed to explore its effectiveness relevant to mortality outcomes. Practical guidance including assessment, monitoring, dosing, safety, and communication with other healthcare providers is discussed.

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Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

“…49 The third study used IVC with a ketogenic diet in patients with advanced cancers and noted decreases in inflammatory markers. 20 Due to the multimodal interventions, it is difficult to know what impact IVC had compared with the other treatments.…”

Section: Impact On Quality Of Life and Treatment Toxicitymentioning

confidence: 99%

Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners

Conte,

Rizzolo,

Flower

et al. 2024

CANDJ

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“…W niszczeniu komórek nowotworowych witamina C wykorzystuje swoje strukturalne podobieństwo w budowie do glukozy. Gdy jest suplementowana dożylnie w dużych dawkach utleniana jest do kwasu dehydroaskorbinowego (DHA), który przechodzi szereg procesów utleniania i redukcji dzięki czemu dochodzi do wzrostu poziomu reaktywnych form tlenu, co przyczynia się do śmierci komórek na drodze apoptozy wywołanej kryzysem energetycznym [15,16]. Omawiane mechanizmy muszą zostać potwierdzone w dobrze kontrolowanych badaniach klinicznych, jednakże odkrycia dotyczące przeciwnowotworowych właściwości witaminy C są wysoce obiecujące i mogą pomóc zidentyfikować grupę chorych , która może odnieść największe korzyści z terapii dużymi dawkami witaminy C, opracować skuteczne strategie łączenia i poprawić ogólny projekt przyszłych badań klinicznych dotyczących witaminy C w różnych typach raka [17,18].…”

Section: Ivc Vit C I Jej Wpływ Na Proces Nowotworowyunclassified

New uses for vitamin C, and its versatile, pleiotropic antioxidant action. - Treatment of neoplasms, skin diseases, bone diseases and stimulation of the immune system

ADAMUS¹,

ABRAM²,

Patryk

et al. 2023

J Educ Health Sport

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Introduction: Vitamin C (Vit C) is an organic chemical compound from the group of unsaturated polyhydroxy alcohols. It influences physiological processes such as the facilitation of iron absorption, hormone and carnitine synthesis, and is also involved in epigenetic processes. It is a vitamin, which means that it must be provided in food. It is also an antioxidant used as a food additive. In recent times, its pleiotropic use has been proven in the treatment of immune deficiencies, the treatment of skin diseases, bone diseases and may also be used in new cancer treatment regimens. Aim of the study: To review the current literature on the use of vitamin C in various fields of health and science. Materials and Methods: We reviewed the literature available in PubMed, using the key words: "vitamin C"; "ascorbid acid"; "cancer treatment"; "vitamin C immune function". Results: Vitamin C has pleiotropic effects on the human body, both through its effects on cells and tissues and through its antioxidant mechanisms and regulation of gene expression. It has been shown to be a key antioxidant with anti-inflammatory and immune system supportive effects. Its effect of slowing down skin photo-ageing by reducing the amount of metalloproteinases induced by reactive oxygen species has been noted in the literature. Vitamin C has been shown in studies to reduce the risk of osteoporosis due to its osteoclast inhibitory properties. Beneficial effects of high-dose intravenous infusions have also been demonstrated in the treatment of cancer, as well as about reducing organ failure and vascular damage in patients with ARDS and sepsis. Summary: The versatile action of vitamin C has made it the subject of intense research. However, the reports in the literature to date on its use require further studies on larger groups of people to confirm its effects.

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“…Di Tano et al demonstrated that fasting-mimicking diet and VitC treatment exerted a synergistic effect on oxidative damage and chemotherapy-induced cytotoxicity in KRAS-mutant tumors [ 99 ]. In another study, patients who received IVC after ketogenic therapy had increased levels of ketone bodies and reduced generalized inflammation compared to pretreatment [ 98 ]. Despite the encouraging results, the safety of this calorie restriction strategy remains disputable, considering cancer patients often experience malnutrition and increased energy expenditure.…”

Section: Application Of Vitc As a Single Agent Or Adjuvant To Target ...mentioning

confidence: 99%

Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

Zhang

Feng

et al. 2022

Cancers

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Based on the enhanced knowledge on the tumor microenvironment (TME), a more comprehensive treatment landscape for targeting the TME has emerged. This microenvironment provides multiple therapeutic targets due to its diverse characteristics, leading to numerous TME-targeted strategies. With multifaced activities targeting tumors and the TME, vitamin C is renown as a promising candidate for combination therapy. In this review, we present new advances in how vitamin C reshapes the TME in the immune, hypoxic, metabolic, acidic, neurological, mechanical, and microbial dimensions. These findings will open new possibilities for multiple therapeutic avenues in the fight against cancer. We also review the available preclinical and clinical evidence of vitamin C combined with established therapies, highlighting vitamin C as an adjuvant that can be exploited for novel therapeutics. Finally, we discuss unresolved questions and directions that merit further investigation.

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Effect of high-dose intravenous ascorbic acid on cancer patients following ketogenic diet

Cited by 5 publications

References 8 publications

Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners

Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners

New uses for vitamin C, and its versatile, pleiotropic antioxidant action. - Treatment of neoplasms, skin diseases, bone diseases and stimulation of the immune system

Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment

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