Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig

Tossou, Myrlene Carine B.; Liu, Hongnan; Bai, Miaomiao; Chen, Shuai; Cai, Yinghua; Duraipandiyan, Veeramuthu; Liu, Hongbin; Adebowale, Tolulope; Al-Dhabi, Naïf Abdullah; Long, Lina; Tarique, Hussain; Oso, A.O.; Liu, Gang; Yin, Yulong

doi:10.1155/2016/2912418

Cited by 60 publications

(44 citation statements)

References 24 publications

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“…The present results also showed that the main antioxidant enzyme, GCLc, decreased in percentage in the jejunum after diquat injection. These results indicate that diquat induced oxidative stress in piglets, which is in accordance with the previous research [7,20,25,26].…”

Section: Discussionsupporting

confidence: 93%

Dietary Puerarin Supplementation Alleviates Oxidative Stress in the Small Intestines of Diquat-Challenged Piglets

Yuan

Liu

et al. 2020

Animals

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This study was conducted to demonstrate that dietary puerarin supplementation alleviates oxidative stress in the small intestine of diquat-challenged piglets. The results showed that puerarin administration markedly alleviated diquat-induced intestinal injury, which was indicated by the improvement of intestinal morphology, cell proliferation and barrier function. One of the potential mechanisms responsible for this was the decrease in oxidative stress, as evidenced by the increase in activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC) in the small intestine. Puerarin increased the protein expression levels of NF-E2-related factor 2 (Nrf2) and its downstream enzymes, including heme oxygenase 1 (HO-1), glutamate–cysteine ligase catalytic and its modifier subunit (GCLc and GCLm) in the jejunal mucosa of diquat-induced piglets. Puerarin administration improved intestinal morphology, cell proliferation, and barrier function, and increased Nrf2 and its downstream enzymes. These findings indicate that the dietary supplementation of puerarin attenuates the oxidative stress involving Nrf2 signaling pathways in diquat-challenged piglets.

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Section: Discussionsupporting

confidence: 93%

Dietary Puerarin Supplementation Alleviates Oxidative Stress in the Small Intestines of Diquat-Challenged Piglets

Yuan

Liu

et al. 2020

Animals

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“…An excessive increase in the activity of these viscera could depress the growth performance by decreasing the organic function and enzymatics of the birds. On the other hand, protein-rich feeds such as canola meal increase the relative weight of the liver in broiler by the high concentration of glucosinolate (Tossou et al, 2016;Woyengo, Kiarie, & Nyachoti, 2011). It is worth noting that the biological responses depend on dietary components.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary enzymolysis products of wheat gluten on the growth performance, serum biochemical, immune, and antioxidant status of broilers

Fang

Martínez

Deng

et al. 2017

Food and Agricultural Immunology

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This study is aimed at determining the effects of dietary enzymolysis products of wheat gluten on the growth performance, organ weights, serum and intestinal antioxidant indices, serum biochemical indicators, and immunoglobulins of broiler chickens. The treatments consisted of a basal control diet, 2% of wheat gluten, and 1%, 2%, 3%, and 4% of enzymolysis products of wheat gluten. The inclusion of up to 4% of enzymolysis products of wheat gluten improved body weight and average daily gain. At 21 days, serum superoxide dismutase (T-SOD) had increased in the 2% of wheat gluten treatment (P < .05). At 42 days, both serum T-SOD and blood urea nitrogen had increased while uric acid had decreased (P < .05) in 2% enzymolysis products of wheat gluten treatment. These results showed that dietary inclusion of 2% enzymolysis products of wheat gluten can have beneficial effects on the growth performance and intestinal antioxidant activities of broiler chickens.

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“…In addition to this, its production stimulated peripheral monocytes [40]. Tossou et al reported that tryptophan played the role of regulating physiological functions and intestinal permeability in the alimentary tract [41]. Hyeyoung Kim reviewed the glutamine, another essential immune nutrient.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Immunonutrition on the Postoperative Complications in Thymoma with Myasthenia Gravis

Cai

Wu³

et al. 2016

Mediators of Inflammation

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Object. To test whether preoperative immunonutrition is efficacious in reducing postoperative complications in patients of thymoma with myasthenia gravis (MG). Material and Methods. A total of 244 patients operated on for thymoma with myasthenia gravis were prospectively assigned to two groups, each receiving seven-day preoperative and seven-day postoperative nutrition. The patients in immunonutrition group were given oral immunonutrition (IN). The patients in control group received oral standard nutrition. Immunonutritional and inflammatory biomarkers (IgA, IgG, IgM, CD3t, CD4t, CD8t, CD4t/CD8t ratio, NK-cell, prealbumin, albumin, white blood cells counts, and C-reactive protein) and clinical variables (age, gender, BMI, performance status, type of thymoma, type of MG, operative time, pathology, operative approach, postoperative complications, quantity of drainage, hospital stays) were examined. Results. A significant reduction in the length of hospital stay, quantity of drainage, and postoperative complications was observed in the IN group (p < 0.05). An increase in the level of IgA, IgG, IgM, CD3+T, CD4+T, CD4+T/CD8+T, WBC, CRP, and NK-cell in the IN group was observed after thymectomy, while a decrease was seen with regard to prealbumin and albumin (p < 0.05). Conclusion. Preoperative immunonutrition support is effective in reducing postoperative complications in patients of thymoma with MG. It helps to lower the risk of postoperative infectious complications and hospital stays.

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Effect of High Dietary Tryptophan on Intestinal Morphology and Tight Junction Protein of Weaned Pig

Cited by 60 publications

References 24 publications

Dietary Puerarin Supplementation Alleviates Oxidative Stress in the Small Intestines of Diquat-Challenged Piglets

Dietary Puerarin Supplementation Alleviates Oxidative Stress in the Small Intestines of Diquat-Challenged Piglets

Effects of dietary enzymolysis products of wheat gluten on the growth performance, serum biochemical, immune, and antioxidant status of broilers

The Effect of Immunonutrition on the Postoperative Complications in Thymoma with Myasthenia Gravis

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