Effect of high concentration of phytase supplementation on energy and nutrient digestibility of growing pigs fed with reduced dietary crude protein balanced with limiting amino acids

Lala, A. O.; Oso, A.O.; Osafo, E.L.K.; Houdijk, J.G.M.; Eyarefe, David O.

doi:10.1016/j.livsci.2020.104143

Livestock Science

2020

DOI: 10.1016/j.livsci.2020.104143

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Effect of high concentration of phytase supplementation on energy and nutrient digestibility of growing pigs fed with reduced dietary crude protein balanced with limiting amino acids

A. O. Lala

A.O. Oso

E.L.K. Osafo

et al.

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2023

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Recombinant Phytase Modulates Blood Amino Acids and Proteomics Profiles in Pigs Fed with Low-Protein, -Calcium, and -Phosphorous Diets

Shili,

Kiyimba,

Hartsen

et al. 2023

IJMS

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A beneficial effect of corn-expressed phytase (CEP) on the growth performance of pigs fed with very low-protein (VLP) diets was previously shown. Little is known whether this improvement is related to alterations in the expression profiles of blood proteins and amino acids (AAs). The objective of this study was to investigate whether supplementation of VLP, low-calcium (Ca), and low-P diets with a CEP would alter the blood AAs and protein expression profiles in pigs. Forty-eight pigs were subjected to one of the following groups (n = 8/group) for 4 weeks: positive control (PC), negative control-reduced protein (NC), NC + low-dose CEP (LD), NC + high-dose CEP (HD), LD with reduced Ca/P (LDR), and HD with reduced Ca/P (HDR). Plasma leucine and phenylalanine concentrations were reduced in NC; however, the LD diet recovered the concentration of these AAs. Serum proteomics analysis revealed that proteins involved with growth regulation, such as selenoprotein P were upregulated while the IGF-binding proteins family proteins were differentially expressed in CEP-supplemented groups. Furthermore, a positive correlation was detected between growth and abundance of proteins involved in bone mineralization and muscle structure development. Taken together, CEP improved the blood profile of some essential AAs and affected the expression of proteins involved in the regulation of growth.

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Recombinant Phytase Modulates Blood Amino Acids and Proteomics Profiles in Pigs Fed with Low-Protein, -Calcium, and -Phosphorous Diets

Shili,

Kiyimba,

Hartsen

et al. 2023

IJMS

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show abstract

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Effect of high concentration of phytase supplementation on energy and nutrient digestibility of growing pigs fed with reduced dietary crude protein balanced with limiting amino acids

Cited by 1 publication

References 43 publications

Recombinant Phytase Modulates Blood Amino Acids and Proteomics Profiles in Pigs Fed with Low-Protein, -Calcium, and -Phosphorous Diets

Recombinant Phytase Modulates Blood Amino Acids and Proteomics Profiles in Pigs Fed with Low-Protein, -Calcium, and -Phosphorous Diets

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