Effect of Hexamethonium Iodide on Gastric Secretion and Motility

Kay, A. W.; Smith, A. N.

doi:10.1136/bmj.1.4651.460

Cited by 41 publications

(12 citation statements)

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“…The resting state is modeled with some pump activity, yielding H ϩ secretion that is 2% of maximal. The normal stomach maintains a pH of ϳ2 in the absence of food (21,28), requiring that basal acid secretion exceed surface-cell HCO 3 Ϫ secretion (41). In addition, the parietal cell's H2 histamine receptors have been found to have a basal level of activity that can be further lowered by "H2 blockers" that are now known to function as "inverse agonists" (51).…”

Section: Resultsmentioning

confidence: 99%

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K⁺]

Crothers

Forte

Machen

2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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Section: Resultsmentioning

confidence: 99%

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K⁺]

Crothers

Forte

Machen

2016

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Moreover, while the oral administration of glucose is satisfactory for aborting early and minimal hypoglycaemic symptoms in a patient receiving both hexamethonium and small doses of insulin, once deeper hypoglycaemic levels have appeared, particularly coma, then the administration of sugared water either orally or by stomach tube is both valueless and dangerous. Interruption in this case must be by the intravenous route, a stricture endorsed by the work of Kay and Smith (1950) and Douthwaite and Thorne (1951), who reported that hexamethonium interferes with the motility and secretion of the stomach.…”

Section: Discussionmentioning

confidence: 84%

Modification of Hypoglycaemia with Hexamethonium Bromide

Marley¹

1957

BMJ

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“…In a previous paper (Kay and Smith, 1950) we have shown that this compound, when given intramuscularly, inhibits the gastric secretion and motility. In the present paper we give the results obtained with the same drug administered by mouth, and also compare the effects of the other halides.…”

mentioning

confidence: 86%

Effect of Oral Hexamethonium Salts on Gastric Secretion

Kay¹,

Smith²

1950

BMJ

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Hexamethylene-bistrimethyl-ammonium (hexamethonium) iodide (C6) has been shown by Paton and Zaimis (1949) to exert a blocking effect at the synapses of autonomic ganglia. In a previous paper (Kay and Smith, 1950) we have shown that this compound, when given intramuscularly, inhibits the gastric secretion and motility. In the present paper we give the results obtained with the same drug administered by mouth, and also compare the effects of the other halides.In the first series of experiments we have observed the effect of a single dose of the iodide salt on the gastric secretion; in the second, the effect of repeated administration; and in the third, the comparative effects of equivalent doses of the iodide, bromide, and chloride.Effect on Spontaneous Gastric Secretion Ten male patients with duodenal ulceration were selected for study. Cases of peptic ulcer complicated by organic stenosis were excluded, since it was felt that the use of hexamethonium iodide would exaggerate gastric retention. Secretion tests were begun at 9 a.m., after a 12-hour fasting period. In the control test, specimens were aspirated every 30 minutes for a period of three hours. On the following day 500 mg. of the drug was given by stomach tube immediately on removal of the fasting juice. After one hour specimens were aspirated at 30-minute intervals. This method was used for six patients. In the other four, to avoid aspiration of unabsorbed drug retained in the stomach, the first aspiration was delayed until two hours after giving the drug.At each aspiration the stomach was emptied, and the volume, bile staining, and titratable free ml. Nil hydrochloric acid were noted. All saliva was % expectorated. It will be seen from Figs. 1 60 and 2 that achlorhydria was reached in five patients, being of short duration in three and 40 lasting four hours in the other two. Of the remainder, three patients showed an appre-500 20 ciable fall in the level of acidity. Two, how-C6 ever, showed no significant change. That the reduction of acidity was due to diminished -2 -21 secretion and not to regurgitation of duodenal juice was indicated by the small volume of the 80 fluid withdrawn and the absence of bile. Effect of a Repeated Dose on SpontaneousGastric Secretion In view of the variable results noted above, it seemed desirable to determine if consistent results were obtained in individual patients. With this in view 500 mg. of hexamethonium iodide was administered to four patients on two successive occasions and the results compared with preliminary and final controls. As in the first group, the drug was given

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Effect of Hexamethonium Iodide on Gastric Secretion and Motility

Cited by 41 publications

References 1 publication

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K⁺]

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K⁺]

Modification of Hypoglycaemia with Hexamethonium Bromide

Effect of Oral Hexamethonium Salts on Gastric Secretion

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Effect of Hexamethonium Iodide on Gastric Secretion and Motility

Cited by 41 publications

References 1 publication

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K+]

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K+]

Modification of Hypoglycaemia with Hexamethonium Bromide

Effect of Oral Hexamethonium Salts on Gastric Secretion

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Product

Resources

About

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K⁺]

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K⁺]