Effect of Heparinoid and Spirolactone on the Renal Excretion of Sodium and Aldosterone

Cejka, V.; Vries, L.A. De; Smorenberg-Schoorl, M.E.; Daatselaar, J.J. Van; Borst, Jannie; Majoor, C.L.H.

doi:10.1016/s0140-6736(60)90242-7

Cited by 38 publications

(10 citation statements)

References 3 publications

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“…One additional factor which must be considered is the effect of heparin administration during each of the dialyses. Heparin in doses of 300-400 mg per day has been shown to suppress aldosterone excretion and promote natriuresis and potassium retention (27,28).…”

Section: Resultsmentioning

confidence: 99%

The Regulation of Aldosterone Secretion in Anephric Man

Bayard¹,

Cr²,

Dj³

et al. 1971

J. Clin. Invest.

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A B S T R A C T The regulation of aldosterone secretion in anephric man was investigated in studies on nephrectomized patients who were being intermittently hemodialyzed while awaiting renal transplantation. The effects of supine and upright posture on the concentration of plasma aldosterone on the 1st day postdialysis and on a 3rd or 4th day postdialysis were compared to the effects of postural variation in normal subjects who were on a low sodium intake and on a high sodium intake. In contrast with the normal subjects who exhibited higher concentrations of plasma aldosterone after 2 hr of upright posture than in the supine position and low concentrations of plasma aldosterone on a high sodium intake, the anephric patients showed less consistent variations in plasma aldosterone due to changes in posture and exhibited higher concentrations of plasma aldosterone on the 3rd or 4th day postdialysis, despite an increase in body weight, than on the 1st day postdialysis.The increase in the concentration of plasma aldosterone in the anephric patients between the 1st day postdialysis and the 3rd or 4th day postdialysis indicates that aldosterone secretion is not responding primarily, in this situation, to volume-related stimuli.There was a high degree of correlation between the concentration of plasma aldosterone and the corresponding levels of serum potassium concentration, which also rose significantly between the 1st day postdialysis and the 3rd or 4th day postdialysis. Furthermore, when poParts of this work were presented at the 3rd Annual

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Section: Resultsmentioning

confidence: 99%

The Regulation of Aldosterone Secretion in Anephric Man

Bayard¹,

Cr²,

Dj³

et al. 1971

J. Clin. Invest.

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“…Aldosterone studies in this species are now in progress in the authors' laboratory in order to elucidate the somewhat different results of Muldowney and Banks' and the present observations. Since kaliuresis was most striking in dogs treated with very toxic compounds (SP 54 and sulfated lignane derivatives 4 ) and was only seen in man during treatment with the high molecular compound SN-175, it is possible that this phenomenon is somehow linked with the toxicity of the compound tested.…”

Section: Discussionmentioning

confidence: 99%

“…We cannot exclude with certainty the possibility that the difference found between the first day of heparin administration and each of the pretreatment days could not be caused by the fact that the patients had not yet reached complete sodium balance on their sodium restricted diets. It must be emphasized, however (as indicated in Table 3), that 4 In a short series of unpublished experiments in dogs, the diuretic effect of intramuscular administration of 3 sulfated lignane derivatives, obtained by courtesy of Drs. Fr.…”

Section: Discussionmentioning

confidence: 99%

“…The effect upon sodium excretion was delayed for a period of 36 to 48 hours after the first injection; the response continued for about 48 hours after therapy had been stopped. In some patients with severe heart failure, the onset of natriuresis was even delayed until the fourth to eighth day of drug administration (2,4,6,13). In many patients a slight potassium retention was found (1,2), usually most pronounced when the natriuresis was large, but insufficient to explain the effect of heparin on the basis of a blocked sodiumpotassium exchange in the renal tubules alone.…”

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confidence: 99%

“…In 1960, Schlatmann et al (3) reported experiments showing that the heparinoids thrombocid (xylan polysulfuric acid) and Rol-8307 (N-formylchitosan polysulfuric acid) have a diuretic action similar to that of natural heparin. Evidence was presented to show that during heparin-or heparinoidinduced natriuresis urinary aldosterone excretion fell to very low levels (4,5). This finding, which was surmised in 1957 (1) because of the potassium retention during heparin administration, was substantiated in subsequent studies (6,7).…”

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confidence: 99%

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The Natriuretic and Aldosterone-Suppressive Action of Heparin and Some Related Polysulfated Polysaccharides1

Schlatmann

Jansen

Prenen

et al. 1964

The Journal of Clinical Endocrinology & Metabolism

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In order to extend earlier observations on the natriuretic effect of heparinoids in man, the effect of several sulfated polysaccharides on urinary sodium and potassium excretion was studied in dogs receiving low sodium diets. In patients, the effect of heparinoids, not tested before, on the excretion of sodium, potassium, creatinine and aldosterone was studied to extend previous observations in man. The pattern of sodium excretion observed in dogs during treatment with certain heparinoids differs from that seen in man in that natriuresis starts on the first day of drug administration. As in man, the enhanced sodium output continues for several days after injections of the drug are terminated. As in earlier studies, it was observed that urinary aldosterone excretion in man during natriuresis induced by the heparinoid, Rol-8307 (N-formyl-chitosan polysulfuric acid), fell to very low levels. The same result was obtained with SP 54 (xylan polysulfuric acid). On the contrary, chondroitin sulfate A showed only a slight and indefinite fall in urinary aldosterone excretion. From a survey of the results obtained with 4 heparinoids in dogs and 6 polysulfated polysaccharides in man, the tentative conclusion is reached that a relatively high sulfate content of the drugs is necessary for a natriuretic effect to occur. Although the mechanism by which heparin and related polysaccharides cause natriuresis and elicit a fall of urinary aldosterone excretion is not known, some facts from the literature suggest that these compounds may interfere with the renin-angiotensin system. (J. Clin. Endocrinol. & Metab. 24: 35,1964)

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Effect of an anionic polyelectrolyte (polyethylene sulfonate) in patients with cancer Clinical pharmacology of a macromolecule

Regelson

Holland

1962

Clin Pharma and Therapeutics

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Polyethylene sulfonate, an anionic polymer of average molecular weight (13,000) Department of Medicine A, Roswell Park Memorial InstituteThe anionic polyelectrolyte polyethylene sulfonate, in the form of the sodium salt of polymeric ethylene sulfonic acid, has been shown by us to be an active inhibitor of seven transplanted solid tumors in mice. 103 ,105 Polyethylene sulfonate, of an average molecular weight of 13,000, has been reported to be a less potent anticoagulant than native heparin but to have similar lipolytic activity. 26,37,38,42,73 Like heparin, polyethylene sulfonate showed no bone marrow depression on chronic administration to animals but produced pathologic fracture as well as evidence of ulceration of the gastrointestinal tract.26 Earlier clinical study of its lipolytic activity in man was uneventful. 37, 38, 73 Because of its tumor-inhibiting activity in mice, a trial against advanced cancer in man was undertaken.

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Effect of Heparinoid and Spirolactone on the Renal Excretion of Sodium and Aldosterone

Cited by 38 publications

References 3 publications

The Regulation of Aldosterone Secretion in Anephric Man

The Regulation of Aldosterone Secretion in Anephric Man

The Natriuretic and Aldosterone-Suppressive Action of Heparin and Some Related Polysulfated Polysaccharides1

Effect of an anionic polyelectrolyte (polyethylene sulfonate) in patients with cancer Clinical pharmacology of a macromolecule

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