1980
DOI: 10.1111/j.1365-2125.1980.tb05829.x
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Effect of heparin administration on plasma binding of benzodiazepines.

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Cited by 59 publications
(12 citation statements)
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“…Heparin causes a release of the enzymes lipoprotein lipase and hepatic lipase, which in turn hydrolyse plasma triglycerides into non-esterified fatty acids (NEFA) [Fielding et aI., 1974;Krauss et ai., 1974;LaRosa et al, 1972]. Non-esterified fatty acids have been shown to competitively inhibit drug binding to plasma proteins (Desmond et al, 1980;Kessler et al, 1979;Routledge et ai., 1979;Storstein and Janssen, 1976;Van der Vijgh and Oe, 1977;Wood et ai., 1979b). Wood et ai.…”
Section: Administration Of Heparinmentioning
confidence: 96%
“…Heparin causes a release of the enzymes lipoprotein lipase and hepatic lipase, which in turn hydrolyse plasma triglycerides into non-esterified fatty acids (NEFA) [Fielding et aI., 1974;Krauss et ai., 1974;LaRosa et al, 1972]. Non-esterified fatty acids have been shown to competitively inhibit drug binding to plasma proteins (Desmond et al, 1980;Kessler et al, 1979;Routledge et ai., 1979;Storstein and Janssen, 1976;Van der Vijgh and Oe, 1977;Wood et ai., 1979b). Wood et ai.…”
Section: Administration Of Heparinmentioning
confidence: 96%
“…Pharmacokinetic parameters were estimated in each patient by simultaneous fi tting of the observed data in the three phases to Eqs. (1), (17), and (18) using the nonlinear least-squares regression program MULTI. 8 …”
Section: Appendix 1 Appendixmentioning
confidence: 99%
“…A heparin (Pularin, Duncan Flockhart) saline solution (2 units/ml) was used at each sampling time to flush the butterfly needle; no more than 5 ml was used on each occasion. This concentration of heparin is well below that known to influence diazepam binding to serum proteins (Desmond et al, 1980;Naranjo et al, 1980). Blood samples were taken before the injection and 2, 5, 10, 20, 30, 60, 90, 120 inin and 4, 8, 12, 24, 28, 32, 48, 56, 72, 80, and 96 h after drug administration.…”
Section: Methodsmentioning
confidence: 99%