Effect of hemolysis on HIV-1 protease and reverse transcriptase genotyping and phenotyping success: a 2-year analysis

Abstract

Interference of clinical laboratory assays by endogenous and exogenous substances in the blood is well known. To date, there are no clear guidelines on the testing of hemolyzed plasma in clinical laboratories. A conservative approach of alerting the physician with re-sampling is advised. This study focuses on the effect of processed (2006/2007), hemolyzed (in vivo/in vitro) plasma (visual inspection) on genotyping (virco ® TYPE HIV 1) and phenotyping (Antivirogram ®) success at Virco.