Effect of hemoglobin status on humoral immune response of weanling pigs differing in coping styles.

Schrama, J.W.; Schouten, J.M.; Swinkels, J.W.G.M.; Gentry, J.; Reilingh, G. de Vries; Parmentier, H.K.

doi:10.2527/1997.75102588x

Cited by 48 publications

(26 citation statements)

References 15 publications

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“…Piglets that were iron deficient on the weaning day also had lower body weight at the end of the study. These findings are similar to the observations by other authors that piglets that were iron deficient and anaemic at weaning were lighter than pigs with normal Hb levels at weaning [40,41]. In experimental animals lower serum iron levels in cachectic animals did not interfere with higher TIBC, as it was published previously [7,42].…”

Section: Discussionsupporting

confidence: 82%

“…The collected data seem to confirm the thesis about a delicate balance between possible benefits and risks of iron supplementation -the efficacy of iron supplements in combating anaemia and oxidative damage caused by iron excess [40,41]. Well chosen iron supplementation strategy for the post-weaning period may be essential when looking for the best rearing solutions to help farmers produce at optimal level.…”

Section: Discussionmentioning

confidence: 50%

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Can iron work for pigs as a booster?

Urbaniak

Spyrka

Rząsa

2017

Advances in Cell Biology

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Iron deficiency is a common health problem in mammals, especially in growing piglets hence iron administration to suckling piglets is a routine practice in swine production. A total number of 160 weaners were allotted to two experimental groups according to body weight (I -cachectic underweight piglets; II -piglets with appropriate weaning body weight). Additionally, each group was divided into two subgroups, with iron administered to piglets in subgroups IA and IIA on the first day of the experiment. In order to monitor the weight gains in pigs, they were weighed twice. To estimate the haematological status, blood samples were taken on the weaning day from selected piglets (10 in each subgroup). Haematological analyses were conducted using Hb, Ht, RBC, MCV, MCH, MCHC as early anaemia indicators. Additionally plasma iron (PI) and total iron-binding capacity (TIBC) were assessed as parameters of the actual and potential circulating extracellular iron. The aim of the study was to investigate the effect of additional postweaning Fe supplementation on production results. A lower concentration of PI was noted in weaker piglets (Group IA and IB). Throughout the experiment higher daily gains were noted in Group II; differences between Group IIA and IA as well as IB were statistically confirmed at p≤ 0,01. It might be expected that an additional Fe dose applied in weaning piglets can be used as a growth promoter. On the other hand, in case of cachectic animals toxicity of supplemental iron must be taken into consideration. Running title:

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 50%

Can iron work for pigs as a booster?

Urbaniak

Spyrka

Rząsa

2017

Advances in Cell Biology

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“…Blood samples without anti-coagulant were left to clot for 3 h at room temperature and were centrifuged at 3000 3 g for 15 min at 48C. Sera samples were stored at 2208C until analysis for anti-KLH IgG by ELISA as described previously (Schrama et al, 1997). Measurements were performed in duplicates.…”

Section: Measurementsmentioning

confidence: 99%

Behavioural, endocrine and immune responses to repeated social stress in pregnant gilts

Couret

Otten

Puppe

et al. 2009

Animal

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Pregnant sows are exposed to various stressors in intensive pig husbandry that may have negative consequences on their health, reproductive performances and welfare. Social stress is one of these challenges, because gestating sows have to be housed in groups according to EU guidelines (2001/88/CE). The purpose of this study was to determine the consequences of repeated social stress in pregnant female pigs on their behavioural, endocrine and immunological responses and on pregnancy outcome. Pregnant gilts were submitted to a repeated social stress procedure induced by housing unfamiliar gilts in pairs changed twice a week between days 77 and 105 of gestation (S group, n 5 18). Control gilts were housed in stable pairs during the same period (C group, n 5 18). Agonistic behaviour was observed during the first 3 h after each grouping. Skin lesions were numbered 2 h after each grouping. Salivary cortisol was measured before and repeatedly during the 4 weeks of grouping. Gilts were immunized against keyhole limpet haemocyanin (KLH) on days 81 and 95 of gestation. Immunoglobulins G against KLH, proliferative responses to concanavalin A, lipopolysaccharide, pokeweed mitogen and KLH and peripheral blood leukocyte numbers were evaluated 1 week before the first grouping and 3 days after the last one. Agonistic interactions and skin lesions were observed in S gilts at each grouping, although there was a decline between the first and the last grouping ( P , 0.05). The repeated social stress induced a sustained endocrine response as shown by elevated salivary cortisol levels from 1 to 48 h after grouping in S gilts compared to C gilts. The cellular as well as the humoral immunity and the leukocyte numbers were not influenced by social stress. Gestation length tended to be shorter in S gilts ( P 5 0.09), but litter size, piglet weight or mortality at birth were not affected. Variability of the response of S gilts to groupings was partly explained by their average success value determined according to the outcome (defeat or win) of all the groupings. In conclusion, our study demonstrates that the application of repeated social stress to pregnant gilts during the last third of their gestation repeatedly activates their hypothalamo-pituitary-adrenal axis but does not impair their immune function and pregnancy outcome.

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“…Interestingly, cellmediated adaptive immunity was suppressed by weaning stress in the proactive but not the reactive pigs. In a separate study, pigs classified by the backtest as proactive also had lower antibody responses (adaptive immunity) to ovalbumin, keyhole limpet hemocyanin and tetanus toxoid than reactive coping-style pigs (Schrama et al 1997). It is noteworthy that behavioural tests used in the identification of coping styles are also used to define temperament in farm animals.…”

Section: Coping Stylesmentioning

confidence: 99%

Resilience in farm animals: biology, management, breeding and implications for animal welfare

2016

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Abstract.A capacity for the animal to recover quickly from the impact of physical and social stressors and disease challenges is likely to improve evolutionary fitness of wild species and welfare and performance of farm animals. Salience and valence of stimuli sensed through neurosensors, chemosensors and immunosensors are perceived and integrated centrally to generate emotions and engage physiological, behavioural, immune, cognitive and morphological responses that defend against noxious challenges. These responses can be refined through experience to provide anticipatory and learned reactions at lower cost than innate less-specific reactions. Influences of behaviour type, coping style, and affective state and the relationships between immune responsiveness, disease resistance and resilience are reviewed. We define resilience as the capacity of animals to cope with short-term perturbations in their environment and return rapidly to their pre-challenge status. It is manifested in response to episodic, sporadic or situation-specific attributes of the environment and can be optimised via facultative learning by the individual. It is a comparative measure of differences between individuals in the outcomes that follow exposure to potentially adverse situations. In contrast, robustness is the capacity to maintain productivity in a wide range of environments without compromising reproduction, health and wellbeing. Robustness is manifested in response to persistent or cyclical attributes of the environment and is effected via activity of innate regulatory pathways. We suggest that for farm animals, husbandry practices that incorporate physical and social stressors and interactions with humans such as weaning, change of housing, and introduction to the milking parlour can be used to characterise resilience phenotypes. In these settings, resilience is likely to be more readily identified through the rate of return of variables to pre-challenge or normal status rather than through measuring the activity of diverse stress response and adaptation mechanisms. Our strategy for phenotyping resilience of sheep and cattle during weaning is described. Opportunities are examined to increase resilience through genetic selection and through improved management practices that provide emotional and cognitive enrichment and stress inoculation.Additional keywords: affective state, allostasis, animal behaviour, animal temperament, animal welfare, disease resistance, genetic selection, homeostasis, resilience, robustness, stress inoculation.

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Effect of hemoglobin status on humoral immune response of weanling pigs differing in coping styles.

Cited by 48 publications

References 15 publications

Can iron work for pigs as a booster?

Can iron work for pigs as a booster?

Behavioural, endocrine and immune responses to repeated social stress in pregnant gilts

Resilience in farm animals: biology, management, breeding and implications for animal welfare

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