Effect of hemoglobin extracted from Tegillarca granosa on iron deficiency anemia in mice

Sun, Bolun; Zhang, Panxue; Wei, Huamao; Jia, Ru; Huang, Tao; Li, Chao; Yang, Wenge

doi:10.1016/j.foodres.2022.112031

Cited by 9 publications

(10 citation statements)

References 44 publications

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“…Food & Function our previously published article, we demonstrated that the administration of T. granosa hemoglobin at low and high doses resulted in a significant elevation of hemoglobin levels in the blood of IDA mice. 9 Specifically, hemoglobin levels increased from 68.88 g L −1 to 96.88 g L −1 and 126.63 g L −1 for the low and high dose groups, respectively. As shown in Fig.…”

Section: Papermentioning

confidence: 87%

“…Serum ferritin and serum iron were significantly increased in low dose and high dose groups, about 26.33-91.35% and 29.74-98.49% greater than in the anemia mouse group, respectively, while TIBC was reduced by 13.43% for the low dose group and 42.44% for the high dose group, respectively. 9 Ferritin is an important protein that stores iron in the body and is used as an additional indicator of iron deficiency. 51 A pronounced reduction in the levels of serum ferritin and serum iron was observed during iron deficiency, and these abnormal values were reversed upon subsequent administration of hemoglobin supplementation.…”

Section: Papermentioning

confidence: 99%

“…8 Recently, we also found that hemoglobin from T. granosa exhibited significant in vivo therapeutic effects on IDA mice. 9 Iron is mainly absorbed in the duodenum and then either stored by ferritin or released into the blood stream via ferroportin (FPN). 10 Unabsorbed iron enters the colonic lumen where the gut microbiota acquires iron via a siderophoremediated iron uptake system.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] Our previous studies using in vitro and in vivo assays confirmed the excellent iron bioavailability of hemoglobin from T. granosa. 9,21 Yet, little research on the effects of hemoglobin on the gut microbiota has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…8 Recently, we also found that hemoglobin from T. granosa exhibited significant in vivo therapeutic effects on IDA mice. 9…”

Section: Introductionmentioning

confidence: 99%

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Effects of hemoglobin extracted from Tegillarca granosa on the gut microbiota in iron deficiency anemia mice

et al. 2023

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Section: Papermentioning

confidence: 87%

Section: Papermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…8 Recently, we also found that hemoglobin from T. granosa exhibited significant in vivo therapeutic effects on IDA mice. 9…”

Section: Introductionmentioning

confidence: 99%

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Effects of hemoglobin extracted from Tegillarca granosa on the gut microbiota in iron deficiency anemia mice

et al. 2023

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Anti‐anemic potential of Eruca sativa L. in iron‐deficient rat model; network pharmacology profiling

Javed,

Shahzadi,

Yousaf

et al. 2024

Food Science & Nutrition

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Iron deficiency anemia is a global health concern, affecting around 2 billion people. Oral iron therapy often causes severe gastro‐intestinal issues. Eruca sativa, member of the Brassicaceae family, is valued in traditional medicine and renowned for its rich iron and vitamin C content. This study aims to evaluate the anti‐anemic properties of E. sativa extract in vivo and identify its compounds targeting anemia mechanisms using network pharmacology. Thirty‐two Sprague–Dawley rats (200 ± 250 g) were split into two distinct groups, iron‐deficient and iron‐sufficient. Three different doses (200, 400, and 800 mg/kg) of aqueous extract of E. sativa were checked against anemia by studying hematological, oxidative stress, and histopathological parameters. GC–MS analysis of E. sativa revealed its phytochemical profile, followed by ADME screening. Network pharmacology explored targets related to iron deficiency anemia, with oral bioavailability and drug likeness assessment for compounds. The administration of extracts significantly improved various blood parameters, including osmotic fragility, Hb, RBCs, MCV, PCV, and alkaline phosphatase; catalase activity; and histopathological parameters such as liver in both iron‐deficient and iron‐sufficient rats (p < .001). Seventy‐nine compounds were identified in E. sativa aqueous extract, with only six of them found to be bioavailable and drug‐like against multiple targets. Gene ontology and pathway analysis revealed their diverse molecular, biological, and cellular functions. One gene EGFR was found to have functional association with ID anemia, suggesting potential for using E. sativa extracts. The study concludes that E. sativa extract has potential for iron deficiency anemia treatment, offering hope for future pharmaceutical interventions.

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Hemocyte proliferation is associated with blood color shade variation in the blood clam, Tegillarca granosa

Yang

Jin

et al. 2023

Aquaculture

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Effect of hemoglobin extracted from Tegillarca granosa on iron deficiency anemia in mice

Cited by 9 publications

References 44 publications

Effects of hemoglobin extracted from Tegillarca granosa on the gut microbiota in iron deficiency anemia mice

Effects of hemoglobin extracted from Tegillarca granosa on the gut microbiota in iron deficiency anemia mice

Anti‐anemic potential of Eruca sativa L. in iron‐deficient rat model; network pharmacology profiling

Hemocyte proliferation is associated with blood color shade variation in the blood clam, Tegillarca granosa

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