Effect of Hemodialysis on Plasma Beta Thromboglobulin Levels

Aj, Adler; Ap, Lundin; Ea, Friedman; Gm, Berlyne

doi:10.1097/00002480-197902500-00065

Cited by 13 publications

(3 citation statements)

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“…Previous attempts to correct incontinence have had only limited success, which depended totally on the etiology of the incontinence and the method used (1)(2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Failure of Platelet Markers to Evaluate Membrane Biocompatibility During a Combined Hemodialysis‐Hemoperfusion Treatment

et al. 1987

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Plasma levels of the platelet markers P-thromboglobulin (P-TG) and platelet factor 4 (PF,) are among the most sophisticated indexes of biocompatibility available to evaluate new members for hemodialysis. This investigation was designed to determine the extent of platelet activation by measuring the a-granule release products, P-TG and PF,; anticoagulation and thrombogenesis by monitoring plasma heparin; and fibrinopeptide A (FPA) and thromboxane B2 (TX B2) levels during treatment with a combined hemodialysis-hemoperfusion system. Both in vivo and in vitro results showed that the platelet markers had a pattern different from that generally observed during treatment with hemodialysis alone. This is due to the avidity of charcoal for the markers studied, which therefore cannot be used to evaluate the biocompatibility of the system.

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“…Previous attempts to correct incontinence have had only limited success, which depended totally on the etiology of the incontinence and the method used (1)(2)(3)(4)(5).…”

Section: Discussionmentioning

confidence: 99%

Failure of Platelet Markers to Evaluate Membrane Biocompatibility During a Combined Hemodialysis‐Hemoperfusion Treatment

et al. 1987

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show abstract

“…High P-thromboglobulin (p-TG) with normal platelet factor 4 (PF4) values have been observed by various authors in the platelet-poor plasma of uremic patients [47][48][49][50]. It is known that P-TG and PF4, two a granule platelet-specific proteins, are released into plasma in simi lar amounts during the process of platelet activation: how ever, PF4, once secreted, is rapidly taken up by endothe lial cells which are endowed with specific binding sites, whereas circulating P-TG is predominantly cleared by renal parenchyma as a tubular protein [49,51].…”

Section: Platelet Functionmentioning

confidence: 99%

“…It is known that P-TG and PF4, two a granule platelet-specific proteins, are released into plasma in simi lar amounts during the process of platelet activation: how ever, PF4, once secreted, is rapidly taken up by endothe lial cells which are endowed with specific binding sites, whereas circulating P-TG is predominantly cleared by renal parenchyma as a tubular protein [49,51]. The ele vated p-TG values found in uremic patients could be due to an increased release of P-TG into the plasma as a conse quence of accelerated platelet consumption into the bloodstream or.…”

Section: Platelet Functionmentioning

confidence: 99%