Effect of Helicobacter pylori on marginal ulcer and stomal stenosis after Roux-en-Y gastric bypass

Risk Factors for Marginal Ulcer After Gastric Bypass Surgery for Obesity

“…13 However, other studies have found no support for H. pylori being a risk factor for MU. 10,14 It is possible that a subgroup of patients with MU have H. pylori infection with ulcers that behave more like regular peptic ulcers, and thus are easier to treat with standard regimens. 13 Hypertension was indicated as a risk factor for MU in a retrospective single-center study comprising 763 GBP operated patients.…”

“…13 MUs often heal slowly, which results in prolonged PPI treatment, 10 and any effects of Helicobacter pylori (H. pylori) eradication seem limited. 10,14 Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed to enhance the risk of MU, but this is under debate. 8 Use of serotonin re-uptake inhibitors (SSRIs) increase the risk of peptic ulcer bleeding, which might be due to anticoagulant properties, and also ulcerogenic effects on the intestinal mucosa.…”

Is Helicobacter Pylori Associated with an Increased Complication Rate after Sleeve Gastrectomy?

“…14 Similarly, Rawlins et al looked at complication rates of gastric bypass patients who tested positive for H. pylori preoperatively and found no significant difference with those who tested negative. 15 When looking at complications after SG and H. pylori infection there were two reports in the literature that showed no statistically relation. 6,7 One study including 89 SG patients demonstrated a prevalence of H. pylori of 44% based on specimen analysis.…”

The influence of prophylactic proton pump inhibitor treatment on the development of symptomatic marginal ulceration in Roux-en-Y gastric bypass patients: a historic cohort study

“…Moreover, most of the literature found no association between H. pylori and MU formation. There is evidence that MUs are formed by a different pathophysiology than general peptic ulcer disease [15,18,25].…”