Effect of Helicobacter pylori infection on oxidative stresses in patients with chronic gastritis

Abstract

The Helicobacter pylori infection is currently endemic worldwide with high prevalence in developing regions. The infection causes chronic gastritis, gastric and gastric adenoid carcinoma. Infection by H. pylori may act as a risk factor for proteins, lipids and DNA damages. In this study, gastric biopsies were obtained in patients with a chronic gastric to investigate effects of H. pylori infection on oxidative stress in patients with chronic gastritis. Urease test and polymerase chain reaction (PCR) were performed on endoscopic gastric biopsy obtained from 150 subjects. The result showed that the presence of a 492-bp DNA fragment was indicative of a positive reaction, also fresh samples had a positive urease test for H. pylori. Malondialdehyde (MDA) in patients with gastritis as a result of H. pylori were significantly increased as compared to the control groups (p<0.05). Mean ± SE of reduced glutathione (GSH) and total antioxidant capacity (TAC) in patients were decreased significantly (p<0.05). The result shows mean ± SE of oxidized glutathione (GSSG) in patients showed significant increased as compared to the control groups. These finding show that H. pylori infection can cause oxidative stress disorders that may act as risk factors.

Studying Association between Thyroid Disorders and Helicobacter pylori infection in Iraqi Patients

“…The explanation of thyroid hormones affected on lipid metabolism is that thyroid hormone regulates the activity of some key enzymes in lipoproteins transport and ,therefore, alter the lipoprotein levels in hypothyroid patients [26]. As well as there was an association between Helicobacter pylori and lipid abnormalities so, these results were closely related to Ansari et al ., [27] when they found that there was an association between H. pylori infection and increased level of cholesterol and decreased level of HDL thus they suggested that H. pylori infection can be caused a lipid metabolism disorders. Results of the present study were closed to those of Peppa et al, [25] and Kim et al, [28] who recorded significant differences among the low density lipoprotein (LDL) levels in both hyperthyroidism and hypothyroidism groups of patients .…”