Effect of height on alveolar liquid pressure in isolated edematous dog lung

Kc, Beck; Sj, Lai-Fook

doi:10.1152/jappl.1983.54.3.619

Cited by 7 publications

(1 citation statement)

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“…This anomaly in the pev curve is attributed to the dissipation of energy form the lung: part of the energy generated during inspiration is not fully recovered during expiration. Similar hysteresis between the pressure/flow curves was demonstrated in dogs and cats early on; at the time, it was attributed to the "stress relaxation" or stress history of the vessel walls during the decreasing flow limb of the pulmonary blood pressure/flow cycle (Fung and Sobin, 1972a;Frank et al, 1959;Beck and Lai-Fook, 1983). This finding was not a universal one because other studies did not demonstrate such hysteresis (Maseri et al, 1972;Rosenzweig et al, 1970).…”

Section: Hysteresismentioning

confidence: 55%

Pulmonary Hemodynamics

Aggarwal¹,

Groß²,

Porcelli³

et al. 2015

Comparative Biology of the Normal Lung

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Section: Hysteresismentioning

confidence: 55%

Pulmonary Hemodynamics

Aggarwal¹,

Groß²,

Porcelli³

et al. 2015

Comparative Biology of the Normal Lung

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Pulmonary interstitial resistance

Lai-Fook

Conhaim

1987

Ann Biomed Eng

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The mechanical properties of the perivascular interstitium surrounding large pulmonary blood vessels are defined in terms of interstitial fluid pressure, interstitial compliance, and interstitial hydraulic resistance. Interstitial pressure is one of the main forces which determine liquid filtration across the microvascular barrier. Interstitial compliance is a measure of the ability of the interstitium to swell with hydration which increases interstitial pressure and reduces the filtration rate. Interstitial pressure and compliance are functions of the elastic properties of the surrounding lung parenchyma and the vessel wall. Solid continuum mechanics are used to describe the behavior of the lung parenchyma. The transport properties of the interstitium are described in terms of a porous material whose fluid resistance is determined by a permeability constant. The dynamics of interstitial fluid are governed by the coupling of the flow with the elastic environment. An electrical analog model is developed to predict the growth of interstitial fluid cuffs during edema formation.

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