Effect of Heat Stress, Hypoxia and Hypoxia-hyperoxia on Free Radical Production in mice Mus musculus

., A.S.A. Haffor; Al-Johany, Awadh M.

doi:10.3923/jms.2005.89.94

Cited by 16 publications

(4 citation statements)

References 24 publications

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“…Buffalo raised at low altitudes with high ambient temperature and relative humidity in summer may suffer from chronic heat stress, and HA buffalo adapt to hypoxia with highly efficient blood oxygen delivery. Heat stress induces local tissue hypoxia due to blood flow redistribution for increased skin heat dissipation [ 38 , 39 , 40 ], and it was reasonable that no significantly enriched GO terms related to blood oxygen delivery were detected between LA and HA buffalo.…”

Section: Discussionmentioning

confidence: 99%

Physiological and Proteomic Responses of Dairy Buffalo to Heat Stress Induced by Different Altitudes

Lan

Cao²,

Yang³

et al. 2022

Metabolites

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Buffalo are mainly distributed in low-altitude (LA), medium-altitude (MA), and high-altitude (HA) regions characterised by different thermal and oxygen environments in Yunnan province, China. Due to black skin, sparse hair, and the low density of skin sweat glands, buffalo are more sensitive to heat stress. Here, we used data-independent acquisition (DIA) proteomics to reveal a broad spectrum of proteins that play roles in adaptation to the heat stress of buffalo raised at low altitude or hypoxia at high altitude. LA buffalo showed higher body temperatures than MA- and HA buffalo, and HA buffalo had higher levels of GSH and SOD and lower levels of ROS compared to LA and MA buffalo. In 33 samples, 8476 peptides corresponding to 666 high-confidence proteins were detected. The levels of circulating complement proteins in the immune pathways were lower in LA and MA buffalo than in HA buffalo. There were higher levels of alpha-1 acid glycoprotein in LA buffalo than in MA and HA buffalo. Relative to MA buffalo, levels of blood oxygen delivery proteins were higher in LA and HA buffalo. A higher abundance of apolipoproteins was detected in LA and MA buffalo than in HA buffalo. In summary, buffalo adopted similar adaptation strategies to oxidative stress induced by heat stress or hypoxia, including immunological enhancement, high efficiency of blood oxygen delivery, and the inhibition of lipid oxidation.

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Section: Discussionmentioning

confidence: 99%

Physiological and Proteomic Responses of Dairy Buffalo to Heat Stress Induced by Different Altitudes

Lan

Cao²,

Yang³

et al. 2022

Metabolites

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“…A progressive accumulation (build up) of proton (H + ) leak from the inter-mitochondria membrane region to the matrix. It has been shown that exposure to hyperoxia for 24 h resulted in morphologic changes in the inner mitochondrial membrane (Haffor and Al-Johany, 2005;Bin-Jaliah et al, 2009) that are similar to brain inflammation (Manizheh et al, 2011;Fridovich, 1998;Jankov et al, 2003;Jafari et al, 2004). During long duration of hyperoxia exposure such as 48 h the body's antioxidant defenses are overwhelmed by the buildup of ROS in the mitochondria, nucleus, cytosol, membranes and extracellular fluid compartments.…”

Section: Discussionmentioning

confidence: 99%

“…An effective antioxidants system has been shown to protect both rats and mice from hyperbaric hyperoxia (Haffor and Al-Johany, 2005). However, the exact period of exposure for O2 of protection provided by exogenous glutathione administration remain unknown.…”

Section: Ajesmentioning

confidence: 99%

Selenium Effect on Hyperoxia-Induced Glutathione Peroxidase Activity and Free Radicals Production in the Brain

Bin-Jaliah¹

2013

American Journal of Environmental Sciences

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The purpose of this study was to examine the behavior of Glutathione Peroxidase (GPx) activity and Free Radicals (FR) production in the brain during graded hyperoxia exposure with and without selenium preventive intake. Forty two adult male rats were assigned to seven groups, six animals each. The first group served as control and the second, third and fourth groups were exposed to hyperoxia for 24, 48 and 72 h, respectively. The fifth, six and seventh groups were exposed to hyperoxia for 24, 48 and 72 h with selenium treatment. Following the exposure period for each group animals were sacrificed and brain tissues were homogenized for GPx and FR analysis. The results of 2-way ANOVA showed that the main effects of both selenium and hyperoxia were significant (p<0.05) for GPx. However, FR production was significantly (p<0.05) affected by hyperoxia only. Pair-wise means comparisons showed that the corresponding means (±) SD of GPx activity decreased significantly (p<0.05), from baseline non-selenium values of 13841.72±1245.67 and 14594.89±6711.50 to 5741.72±949.31 and 4829.98±775.52 following 24 and 48 h of hyperoxia exposure respectively, then increased to 7846.19±2467.69, following 72 h of hyperoxia exposure, as compared with non-selenium mean value of 4346.38±349.14. These differences were attributed to the ability of brain tissue to use selenium to reduce the requirements for GPx during 24 and 48 h as such to spare the integrity of its antioxidant mechanism during 72 h. Based on the results of the present study selenium's supplement and diet rich selenium are recommended for TBI patients.

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“…In addition, IHHT has been used to accelerate the recovery of athletes with over training syndrome ( Susta et al, 2017 ). The underlying physiological mechanism may be associated with upregulation of adaptive reactive oxygen species (ROS) signaling, because of increased ROS production during ischemic–reperfusion stress ( Haffor and Al-Johany, 2005 ), resulting in better antioxidant capacity adaptation ( Sazontova et al, 1994 ). However, the effects of acute systemic hypoxia–hyperoxia preconditioning on EIMD are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Effects of Hypoxia–Hyperoxia Preconditioning on Indicators of Muscle Damage After Acute Resistance Exercise in Male Athletes

et al. 2022

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PurposeThe purpose of this study was to investigate the effects of acute repeated hypoxia–hyperoxia preconditioning on resistance exercise (RE)-induced muscle damage in male athletes.MethodsEleven young male athletes participated in this randomized double-blind counter-balanced crossover study, and were divided into Normoxia (N) and Hypoxia–Hyperoxia (HH) trials. Subjects of the respective trials were supplied with normoxic (FiO2 = 0.21), or alternating hypoxic/hyperoxic air (FiO2 = 0.10/0.99, 5 min each) for 60 min. Thirty minutes after preconditioning, subjects performed acute bouts of RE consisting of bench press, deadlift, and squats. Each exercise included 6 sets of 10 repetitions at 75% one-repetition maximum (1RM) with 2 min rest between sets. After a 2-week washout period, subjects changed trials and completed the same study procedure after the alternate preconditioning. Muscle soreness, maximal voluntary contraction (MVC), and circulating biochemical markers were tested before preconditioning (baseline) and during recovery at 0, 24, and 48 h after exercise.ResultsAcute RE significantly increased levels of muscle soreness, creatine kinase (CK) and myoglobin (Mb), and decreased levels of peak knee extension torque in the N trial. Muscle soreness, CK, and Mb levels of the HH trial were significantly lower than that of the N trial after exercise. Interestingly, interleukin-6 (IL-6) levels of the HH trial increased significantly 0 h after exercise compared to baseline and were significantly higher than that of the N trial 0 and 24 h after exercise. However, no significant differences of thiobarbituric acid reactive substances (TBARS), cortisol, testosterone, peak torque, and average power levels were found between N and HH trials during recovery.ConclusionOur data suggest that pre-exercise treatment of alternating hypoxic/hyperoxic air could attenuate muscle damage and pain after acute RE, but has no effect on muscle strength recovery in young male athletes.

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Effect of Heat Stress, Hypoxia and Hypoxia-hyperoxia on Free Radical Production in mice Mus musculus

Cited by 16 publications

References 24 publications

Physiological and Proteomic Responses of Dairy Buffalo to Heat Stress Induced by Different Altitudes

Physiological and Proteomic Responses of Dairy Buffalo to Heat Stress Induced by Different Altitudes

Selenium Effect on Hyperoxia-Induced Glutathione Peroxidase Activity and Free Radicals Production in the Brain

Effects of Hypoxia–Hyperoxia Preconditioning on Indicators of Muscle Damage After Acute Resistance Exercise in Male Athletes

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