Effect of health education intervention on hepatocellular carcinoma risk factor prevention in Menoufia governorate, Egypt

Abstract

Background: Hepatocellular carcinoma is an important public health problem worldwide and in Egypt. It has a bad prognosis and few treatment options. HCV and HBV infection and exposure to pesticides and aflatoxins are major risk factors for its development, so paying more attention to prevention via raising population awareness about its risk factors may be useful in lowering HCC incidence. This study was implemented to study knowledge, attitude, and practice (KAP) of a rural community of Menoufia governorate, Egypt, pre-and post-health education intervention about HCC and prevention of its risk factors. Results: Seroprevalence of HCV among study participants was 12.3%, and the health education intervention about HCC and the prevention of its risk factors was effective in increasing the percent of pre-intervention good knowledge score groups about HCC, HBV, and HCV, pesticides, aflatoxins, and total knowledge score from 66.5%, 88.8%, 83.8, 41.9%, and 73.7% respectively to 98.9%, 100%, 100%, and 98.9% post-intervention (p value = 0.000 for each) and was also effective in increasing the pre-intervention positive attitude score groups from 61.5 to 98.9% post-intervention. It was also effective in increasing the pre-intervention safe practice score groups of male and female study participants from 20% and 23% respectively to 94.3% and 93.1% post-intervention.Conclusions: Health education intervention was effective in improving KAP about HCC and prevention of its risk factors and could be adopted by MOHP as a part of comprehensive program for HCC prevention in rural communities of Menoufia governorate.

Profile of Patients of Hepatocellular Carcinoma in The Internal Medicine Inpatient Room at Dr. Soetomo General Academic Hospital

“…High school is the education most patients take in the Internal Medicine Inpatient Room at Dr. Soetomo General Academic Hospital because of HCC with 39 patients (65%). The same thing happened in the research of Yehia et al (2020) that 49.2% of HCC patients had reached the secondary level of education. However, Turati et al (2013) research stated that patients with HCC who reached the level of education for 12 years were the lowest at 14 (8%).…”

CTNNB1 polymorphism (rs121913407) in circulating tumor DNA (ctDNA) in Egyptian hepatocellular carcinoma patients

“…Hepatocellular carcinoma is a primary tumor of the liver, which arises from liver cells and constitutes about 90% of all primary liver cancer types that usually develops in the setting of chronic liver disease, particularly in patients with chronic hepatitis B and C. HCC has a rising incidence in Egypt mostly due to high prevalence of viral hepatitis and its complications [1,2].…”