Effect of Harmane on Mononeuropathic Pain in Rats

Arıcıoğlu, Feyza; Korcegez, Eylem; Özyalçín, Süleyman

doi:10.1196/annals.1304.021

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…Agmatine and harmane are the potent endogenous ligands that activate imidazoline I 1 and I 2 receptor. It is important to note that these agents themselves exhibit antinociceptive profile in neuropathic pain [68,69]. Interestingly, we found that pretreatment of these agents potentiated the antinociceptive effect of ethanol as well as nicotine.…”

Section: Discussionmentioning

confidence: 65%

Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in rats

Aglawe¹,

Taksande²,

Kuldhariya³

et al. 2013

Fundamemntal Clinical Pharma

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Despite synergistic morbidity and mortality, concomitant consumption of alcohol and tobacco is increasing, and their antinociceptive effect has been linked with co-abuse. Present study was designed to investigate the role of imidazoline binding sites in the antinociceptive effect of nicotine, ethanol, and their combination. Separate group of male Sprague-Dawley rats (200-250 g) were treated with different doses of alcohol (0.50-2 g/kg, i.p.) or nicotine (0.25-1 mg/kg, i.p.), and their combination evaluated in tail flick test. Influence of endogenous imidazoline binding site ligands, agonist, and antagonists were determined by their prior treatment with effective or subeffective doses of either ethanol or nicotine. Ethanol, nicotine, or their subeffective dose combination exhibited significant antinociceptive effects in dose-dependent manner. Antinociceptive effect of ethanol and nicotine was significantly augmented by intracerebroventricular (i.c.v.) administration of endogenous imidazoline receptor ligands, harmane (25 μg/rat, i.c.v.) and agmatine (10 μg/rat, i.c.v.), as well as imidazoline I1 /α2 adrenergic receptor agonist, clonidine (2 μg/rat, i.c.v.), I1 agonist moxonidine (25 μg/rat, i.c.v.), and imidazoline I2 agonist, 2-BFI (10 μg/rat, i.c.v.). Conversely, antinociception elicited by ethanol or nicotine or their subeffective dose combination was antagonized by pretreatment with imidazoline I1 antagonist, efaroxan (10 μg/rat, i.c.v.), and I2 antagonist, idazoxan (4 μg/rat, i.c.v.), at their per se ineffective doses. These findings project imidazoline binding ligands as important therapeutic molecules for central antinociceptive activity as well as may reduce the co-abuse potential of alcohol and nicotine.

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Section: Discussionmentioning

confidence: 65%

Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in rats

Aglawe¹,

Taksande²,

Kuldhariya³

et al. 2013

Fundamemntal Clinical Pharma

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“…On the other hand, H induced antidepressant and antianxiety effects in rats, as well as a vasorelaxant effect (19,20), and showed anti-HIV activity by inhibiting replication in H9 lymphocyte cells (21). Meanwhile, it was described that H may have beneficial effects on mononeuropathic pain in rats (22) and on naloxone-precipitated withdrawal syndrome in morphine-dependent rats (23). H also increased insulin secretion from isolated human islets of Langerhans (24).…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Norharman and Harman Contents in Espresso Coffee

Alves

Casal

Oliveira

2007

J. Agric. Food Chem.

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Espresso coffee (EC) brews were analyzed for beta-carboline [norharman (NH) and harman (H)] contents, by RP-HPLC with fluorescence detection. The influence of the coffee species (arabica or robusta), the roast degree, and the brew length was studied. The results show that the content of NH and H in EC is dependent primarily on the coffee species, followed by brew length. The roast degree has only a minor influence on the final content of NH and H in EC. When compared with other coffee brews, EC has an amount of these beta-carbolines (in micrograms per liter) similar to that of mocha coffee, both being more concentrated than filter and press-pot coffees. Therefore, the consumer's preferences will determine the amount of NH and H ingested daily. For the caffeinated 30 mL of EC, the arabica coffees contain about 4.08 microg of NH and 1.54 microg of H. Commercial blends (usually with a maximum of 30% robusta) range from the cited arabica values to 10.37 microg of NH and 4.35 microg of H.

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