A simple, reasonably accurate method was proposed for fatigue limit prediction in ductile cast irons (DCIs) containing small defects, employing an easy‐to‐use prediction equation. A technique was also presented for the estimation of the statistical effects of complex structural discontinuities, as characterized by graphite and casting defects. The validity of these approaches was confirmed by the experimental results obtained via rotating‐bending fatigue tests on six DCIs, with varying distributions of graphite nodule size and different matrix structures.