Effect of halofantrine administration on some liver and heart enzymes in healthy human volunteers

Bassi, PU; Buratai, BI; Kuchali, W

doi:10.4314/ajbr.v9i1.48770

Cited by 4 publications

(4 citation statements)

References 10 publications

(9 reference statements)

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“…In addition, all of our above-mentioned findings are in agreement with those of Bassi et al , who found that halofantrine exhibited cardiotoxic and hepatotoxic effects 20 …”

supporting

confidence: 93%

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Is halofantrine ototoxic? Experimental study on guinea pig cochlea model

et al. 2010

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“…In addition, all of our above-mentioned findings are in agreement with those of Bassi et al , who found that halofantrine exhibited cardiotoxic and hepatotoxic effects 20 …”

supporting

confidence: 93%

“…20 Based on the above data, it was impossible to determine whether the ototoxic effects of halofantrine were reversible or not. 20 Based on the above data, it was impossible to determine whether the ototoxic effects of halofantrine were reversible or not.…”

Section: Discussionmentioning

confidence: 99%

Is halofantrine ototoxic? Experimental study on guinea pig cochlea model

et al. 2010

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“…There is a consistent cardio toxicity reports on large scale use of Halofantrine, a phenatrane-methanol that is highly effective for P. falciparum malaria [27]. Bassi et al, (2006) [28], reported significantly increase activities of liver transaminase (ALT and AST) as well as cardiac enzymes (CK and LDH) following administration of halofantrine compared to baseline values. Damage to any of these tissues (cardiac and skeletal muscles, liver, kidney and erythrocytes) due to toxic injury such as drugs may increase plasma AST levels.…”

Section: Introductionmentioning

confidence: 98%

Biochemical Indices of Cardaic Function of Albino Wistar Rats Exposed to Hippocratea Africana Root Bark Extract

Ndem¹,

David²

2017

IOSR JBB

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“…However, halofantrine is known to have some unwanted side effects, such as abdominal pain, nausea, vomiting, diarrhea, orthostatic, hypertension, prolongation of QTc intervals, pruritus, rash, and hepatotoxic (Karbwang et al 1991;Bassi et al 2006). The 1,10-phenanthroline derivatives are similar to halofantrine as antimalarial drug which its added at heterocyclic with two nitrogen atoms.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimalarial Activity of 2-Phenyl-1,10-Phenanthroline Derivative Compounds

2014

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To develop new potential antimalarial drugs of 2-phenyl-1,10-phenanthroline 5 derivatives from 8-aminoquinoline as starting material were synthesized in good yields. The synthesis of 2-phenyl-1,10-phenanthroline 5 derivatives compounds with 8-aminoquinoline 4 as starting material through three steps has been carried out. The first step of reactions is aldol condensation of benzaldehyde 1 with acetaldehyde 2. The result of reactions is cinnamaldehyde 3 (92.14%) in the form of yellow solid. The second step of reactions was synthesized of 2-phenyl-1,10-phenanthroline 5 (brown solid, 54.63%) through cyclization of 8-aminoquinoline 4 with cinnamaldehyde 3 compound. The third step of reactions is methylation and ethylation of 2-phenyl-1,10-phenanthroline using dimethyl sulphate (DMS) and diethyl sulphate (DES) reagents that it was refluxed for 17 and 19 h, respectively. The results of reactions are (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6 and (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 in yield from 90.62% and 89.70%, respectively. The results of testing in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum FCR3 strain to 2-phenyl-1,10phenanthroline 5 derivatives obtained that (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 compound has higher antimalarial activity (IC 50 :0.13 ± 0.02 µM) than antimalarial activity of (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6 compound (IC 50 :0.25 ± 0.01 µM) and 2-phenyl-1,10-phenanthroline 5 compound (IC 50 :2.45 ± 0.09 µM). While, the results of testing in vitro antiplasmodial activity at chloroquine-resistant Plasmodium falciparum D10 strain to 2-phenyl-1,10phenanthroline 5 derivatives obtained that (1)-N-methyl-9-phenyl-1,10-phenanthrolinium sulphate 6 compound has higher antimalarial activity (IC 50 :0.10± 0.04 µM) than antimalarial activity of (1)-N-ethyl-9-phenyl-1,10-phenanthrolinium sulphate 7 (IC 50 :0.18 ± 0.01 µM) and 2-phenyl-1,10-phenanthroline 5 compound (IC 50 :0.55 ± 0.07 µM).

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Effect of halofantrine administration on some liver and heart enzymes in healthy human volunteers

Abstract: ABSTRACT

Cited by 4 publications

References 10 publications

Is halofantrine ototoxic? Experimental study on guinea pig cochlea model

Is halofantrine ototoxic? Experimental study on guinea pig cochlea model

Biochemical Indices of Cardaic Function of Albino Wistar Rats Exposed to Hippocratea Africana Root Bark Extract

Synthesis and Antimalarial Activity of 2-Phenyl-1,10-Phenanthroline Derivative Compounds

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