Effect of haemodialysis on the antibody-dependent and spontaneous cell-mediated cytotoxicity of patients with chronic renal failure

Làng, István; Taraba, I; Hering, A; Petrányi, G

doi:10.1016/0165-2478(82)90092-x

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…As opposed to renal transplant patients in which there is a disproportionate increase in lymphoreticular malignancies, HD patients have a non selective increase in neoplasms [12][13][14][15]. NK cells and ADCC arc felt to be part of the body's natural immune surveillance against tumors and infection [75,76], Ure mic serum has been found to be inhibitory to both NK and ADCC activity [77], Indepen dent of the 'uremic milieu' the NK cell is affected by HD. Badger et al [78] found improvement in NK function after dialysis.…”

Section: Tumor Surveillancementioning

confidence: 99%

Immune Abnormalities in Renal Failure and Hemodialysis

Kay¹,

Raij²

1986

Blood Purif

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Considerable work needs to be done in order to understand the immunosupressive effect of ‘uremia’ and the lymphocyte changes induced by hemodialysis. For example, the lymphocyte population dynamics can be further defined using monoclonal antibodies specific for lymphocyte subgroups. In vitro assays are available for lymphokine detection (i.e. IL-1, IL-2 which are important for T cell function) and may be correlated with both the clinical state and overall immunobiological status of hemodialyzed patients. The possibility of specifically delineating the extent of the immune system dysfunction in renal failure patients (on or off dialysis) is at hand. With this knowledge it will be possible to manipulate their management so as to minimize function alterations.

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Section: Tumor Surveillancementioning

confidence: 99%

Immune Abnormalities in Renal Failure and Hemodialysis

Kay¹,

Raij²

1986

Blood Purif

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“…Results were heterogeneous: PBMC from some patients performed better, some identical and some worse than PBMC from HI [16]. The other two studies can hardly be interpreted as they only used phagocyte-depleted lymphocytes as effectors [17,18]. We used the EGFR as a therapeutically established target antigen.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only three studies have addressed this subject. In all of them, only peripheral blood mononuclear cells (PBMC), not PMN, were investigated as effector cells, experiments were not performed with therapeutic Abs, and results were contradictory [16,17,18]. …”

Section: Introductionmentioning

confidence: 99%

Antibody-Dependent Cellular Cytotoxicity in Patients on Chronic Hemodialysis

Koch

Derer²,

Staudinger³

et al. 2013

Am J Nephrol

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Background: Antibody (Ab)-dependent cellular cytotoxicity (ADCC) is considered to be a relevant mechanism of action of Ab-based tumor therapies. However, knowledge about ADCC capacity of dialysis patients (DP) is limited. The aim of our study was to investigate if ADCC capacity of effector cells obtained from DP differed from those of healthy individuals (HI). Methods: First, we performed ADCC assays with isolated polymorphonuclear cells (PMN) and peripheral blood mononuclear cells (PBMC), mediated by the epidermal growth factor receptor Ab cetuximab or panitumumab. As cetuximab is of human IgG1 and panitumumab of human IgG2 isotype, both Abs differ in their affinity to Fcγ receptors and effector cell recruitment. Results: Using PMN as effectors, ADCC levels via panitumumab proved to be higher than via cetuximab, but did not differ between DP and HI. In contrast, IgG2-mediated ADCC with PBMC from DP was significantly enhanced compared to HI. IgG2 Abs predominantly bind to FcγRIIa. Within the PBMC, monocytes are the only cytotoxic cells physiologically expressing this receptor. ADCC experiments with isolated monocytes confirmed them to be the pivotal cells for the observed effect. Analysis of monocytes' Fc receptor expression demonstrated no difference between DP and HI, but monocytes of DP proved to be numerically increased and appeared preactivated. Conclusion: Our studies implicate that ADCC capacity is not impaired in DP and that it might particularly be reasonable to apply human IgG2 Abs as therapeutics for these patients.

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Rationalitäts- und Aufklärungskritik — Der Beitrag der ‘Kritischen Theorie’ zu einer Theorie moderner Herrschaft

Bruch¹

2000

Herrschaft in Der Modernen Gesellschaft

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Effect of haemodialysis on the antibody-dependent and spontaneous cell-mediated cytotoxicity of patients with chronic renal failure

Cited by 3 publications

References 11 publications

Immune Abnormalities in Renal Failure and Hemodialysis

Immune Abnormalities in Renal Failure and Hemodialysis

Antibody-Dependent Cellular Cytotoxicity in Patients on Chronic Hemodialysis

Rationalitäts- und Aufklärungskritik — Der Beitrag der ‘Kritischen Theorie’ zu einer Theorie moderner Herrschaft

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