Effect of Haemodialysis on Acoustic Shear Wave Propagation in the Skin

Abstract

Background: Diverse skin alterations may develop in patients under chronic haemodialysis. Among them, signs of premature photo-ageing have been described. Aim: To assess alterations in the physical properties of skin consistent with ageing effects and with cutaneous fluid exchanges during haemodialysis sessions. Methods: In the first part of the study, 45 haemodialysed patients were compared to 45 age-, sex- and body-mass-index-matched healthy subjects. In the second part of the study, skin of 30 haemodialysed patients was assessed immediately before and after a haemodialysis session. The speed of ultrasound shear wave propagation was measured in each subject. Series of 16 multidirectional resonance running time measurements (RRTM) were performed on the forehead and/or the volar forearm. They were averaged for each subject. The corresponding intra-individual coefficients of variation were calculated as an estimate of the skin mechanical anisotropy. Results: In both haemodialysed patients and their matched controls, RRTM values were significantly higher on the forearms than on the forehead. By contrast, no significant difference was found in RRTM values that could be ascribed to chronic haemodialysis. However, RRTM values were significantly increased as an immediate and probably transient effect of haemodialysis sessions. In healthy subjects, ageing was associated with increased RRTM values. Conclusion: Chronic haemodialysis does not appear to influence significantly the functional expression of the dermal ageing process. Subtle fluid movements occurring in the skin during haemodialysis sessions can be assessed by measuring non-invasively the speed of ultrasound shear wave propagation in the skin.

Cutaneous resonance running time is decreased in psoriatic lesions

“…Previous studies have shown that changes of CRRTs occur in various cutaneous and systemic disorders (14,22,25). Besides decreased SC hydration, reduced CRRTs in psoriatic lesions are also demonstrated in present study.…”

“…Maximum CRRT is seen when acoustical shockwave runs cross langer's lines and minimum, along langer's lines, indicating that collagen fibers are determinant of CRRT. It has also been demonstrated that CRRT is negatively correlated with skin stiffness or firmness (21,22). In addition, SC hydration and inflammation influence CRRT (21,23).…”

Decreased Cutaneous Resonance Running Time in Cured Leprosy Subjects

“…CRRT represents another highly sensitive tool to assess skin biophysical properties. With age, CRRT changes with skin stiffness, firmness, thickness, as well as tissue composition [18,19,[47][48][49][50] . Skin firmness is positively correlated with CRRT, while skin stiffness is negatively correlated with CRRT [18] .…”

Cellulite histopathology and related mechanobiology

“…Extensibility, elasticity and resiliency can be improved upon treatment [13, 14]. The speed of shear wave propagation is also an indicator of the intrinsic skin tensions [15–20]. There is evidence that this parameter is affected by cellulite and its treatment.…”