Effect Of HA/TCP Biphasic Ceramic on Osteoinduction

Abstract

The purpose of this study was to evaluate the effect of HA/TCP biphasic ceramic on osteoinduction. HA/TCP ceramic cylinders with Φ8mm*10mm were prepared. The cylinder materials were stained by the calcein and alizarin red respectively, which were implanted into pigs’ dorsal muscle. The samples were harvested at 1, 2 and 3 month post-implantation. At 3 month post-implantation, the new bone tissues were observed in the inner pores of cylinders, which were stained by calcein or alizarin red at the same time, it was also found that the osteoblast in the margin of new bony tissue were stained by calcein and alizarin red. This result indicated that HA/TCP biphasic ceramic are osteoinductive in muscles of pigs, and participate in the process of new bone formation and calcification.