Effect of H1 and H2 agonists on the chemiluminescence of human blood mononuclear cells induced by phytohaemagglutinin

Merétey, K; Bohm, U.; Falus, András

doi:10.1016/0162-3109(85)90013-x

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…Moreover no inhibition occurred at concentrations 10'6-10"10 M The interindividual variation of histamine action was also larger in WB-CL assay and in some cases 10'lu M histamine was capable of slightly activating the leuko cytes. A similar activation of mononuclear cells at his tamine concentrations 10-8-10"11 M was demonstrated by Meretey et al [22,23], who suggested H 1-specific The results of two experiments are given as percentage of the drug-free control.…”

Section: Discussionmentioning

confidence: 55%

“…A similar, but slighter effect of another H 1-antagonist mepyramine has been reported [22,23]. On the other hand, Ozaki et al [24] were unable to demonstrate any action of me pyramine.…”

Section: Discussionmentioning

confidence: 63%

“…On the other hand, Ozaki et al [24] were unable to demonstrate any action of me pyramine. As mepyramine alone at physiological concentrations was inactive it has been suggested that mepyramine blocks the HI-receptors and increases the relative concentration or activity of histamine at the H2-receptors [22,23]. Since diphenhydramine was a potential inhibitor of CL of separated leukocytes also in the absence of histamine, it is likely that di phenhydramine is able to suppress the function of leukocytes also by another mechanism than HI-an tagonism.…”

Section: Discussionmentioning

confidence: 99%

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Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Leino¹,

Lilius²

1990

Int Arch Allergy Immunol

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The effect of histamine and histamine antagonists on the respiratory burst activity of leukocytes was studied. The activity was measured as zymosan-induced luminol-dependent chemiluminescence (CL) of isolated leukocytes and 1:2,500 diluted whole blood (WB). Histamine caused a dose-dependent inhibition of CL. For separated leukocytes the ID50 was 8 × 10^––5M and for WB it was 1.5 × 10^––3M. Diphenhydramine, an H1-antagonist increased the inhibitory effect of histamine while H2-antagonist cimetidine blocked the inhibition of CL of separated leukocytes. Cimetidine was not capable of reversing the effect of histamine on WB-CL. These data suggest that the histamine receptors on leukocytes are associated with Fc and/or complement receptors and the expression and function of histamine receptors can be studied by measuring the respiratory burst activity. The results also provide evidence of differences in histamine action in vitro and ex vivo conditions in WB.

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Section: Discussionmentioning

confidence: 55%

“…A similar, but slighter effect of another H 1-antagonist mepyramine has been reported [22,23]. On the other hand, Ozaki et al [24] were unable to demonstrate any action of me pyramine.…”

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Leino¹,

Lilius²

1990

Int Arch Allergy Immunol

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“…However, these effects were observed with high concentrations of His and H 1 -antagonists (10 to 50 mmol/L), which were 1000-times above the saturable concentration for membrane histamine receptors on PMNL [29]. On the other hand, low concentration of His (0.01-0.1 mmol/L) stimulated human mononuclear cell CL [25]. In fact, His in concentrations which fully occupy its receptors had no effect or slightly potentiated (fMLP) stimulated CL.…”

Section: Discussionmentioning

confidence: 83%

Effect of H1-antagonist Dithiaden® on human PMN-leukocyte aggregation and chemiluminescence is stimulus-dependent

Nosáľ¹,

Drábiková²,

Čı́ž

et al. 2002

Inflamm. res.

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Dithiaden, depending on the stimuli applied, inhibited human neutrophils, both isolated or in whole blood, more markedly than histamine. The inhibition of aggregation and CL was dose- and stimulus-dependent. Histamine administered simultaneously abolished the effect of Dithiaden on fMLP-stimulated PMN-leukocytes. It seems likely that the interaction of Dithiaden with neutrophils operated both at an extra- and intracellular level.

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“…We started our studies in the early eighties with Katalin Merétey on the effect of histamine on the mitogen response of T cell [13]. It has been revealed that histamine inhibits the growth and activation of T cells.…”

Section: Histamine and Immune Responsementioning

confidence: 99%

Histamine, part of the metabolome

Falus

2003

Acta Biologica Hungarica

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Histamine, a decarboxylated amino acid with a molecular mass of 112 daltons reveals multicoloured functional activities. Its role in allergy and inflammation is abundantly characterized. Moreover histamine is one of the neuotransmitters, has a role in gastric acid production and in maintenance of blood-brain barrier. In the last decade, many data were collected suggesting an important function of histamine in events of immune response and also in both benign and malignant cell proliferation. Our group collected data on the relevance of histamine as an autocrine factor in human melanoma. The outcome of the action seems to be closely related to the local and actual balance of histamine receptors (H1R, H2R, H3R and H4R) on tumor cells. Recently, using a gene targeted mouse strain (lacking an enzyme, histidine decarboxylase, the only one responsible for histamine production) many phenotype of the histamine-free mice were demonstrated. Our data suggest, that histamine, as part of the poorly characterized metabolome of the mammalian cells plays significant role in many physiological and pathological processes.

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Effect of H1 and H2 agonists on the chemiluminescence of human blood mononuclear cells induced by phytohaemagglutinin

Cited by 10 publications

References 19 publications

Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Histamine Receptors on Leukocytes Are Expressed Differently in vitro and ex vivo

Effect of H1-antagonist Dithiaden® on human PMN-leukocyte aggregation and chemiluminescence is stimulus-dependent

Histamine, part of the metabolome

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