Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux

Abstract

Background/Aims: To evaluate the occurrence of gastroesophageal reflux and possible mechanisms in Helicobacter pylori infection. Materials and Methods: Symptoms of H. pylori-infected children, their total gastroesophageal reflux episodes, acid exposure percentage, gastrin, ghrelin, and motilin levels were evaluated before and after H. pylori eradication. Results: Forty-two H. pylori-infected children were eligible for this study. Acid exposure % and total reflux episodes before and after H. pylori eradication were 10.2%±14.8% vs. 7.71%±5.0% and 94.7%±102.1% vs. 64.6%±55.0%, respectively (p=0.28, p=0.082). There was an insignificant change in the serum gastrin (93.4±153.8 pmol/L vs. 1.28±149.4 pmol/L, p=0.67), ghrelin (7.69±197.5 pg/mL vs. 8.36±299.5 pg/mL, p=0.274), and motilin (75.1±81.2 pg/mL vs. 97.2±80.5 pg/mL, p=0.206) levels after eradication. Gastrin and ghrelin levels were negatively correlated after H. pylori eradication (r=−0.38, p=0.031). There was no association between gastroesophageal reflux episodes and gastrin, ghrelin, and motilin levels (r=0.25 and p=0.11; r= 0.24 and p=0.13; r=-0.23 and p=0.14, respectively) Conclusion: H. pylori infection is neither protective nor harmful in the gastroesophageal reflux. Neither ghrelin nor motilin levels was associated with gastroesophageal reflux. None of gastrin, ghrelin, and motilin levels was affected by H. pylori infection. There is an inverse association between gastrin and ghrelin levels after H. pylori eradication.

Hypergastrinemia in Long-Term Use of Proton Pump Inhibitors

“…It may be because the patients with spontaneous disappearance due to severe atrophy were may be enrolled as H. pylori -negative. Spontaneous eradication in the patients with severe atrophy would not change acid secretion and hypergastrinemia may continue to be present [42]. Interestingly, the gastrin levels were significantly associated with corpus atrophy only in the subgroup of non-users of PPI but not in the users.…”

Prevalence of Helicobacter pylori is still high among symptomatic Bulgarian children

“…Whether H. pylori infection is positively or inversely associated with GERD in pediatric patients is still a topic of controversy [17][18][19]. Almost half of the children with duodenal ulcer were H. pylori-positive versus only 14.5% of those with GERD, which can support the understanding about an inverse association between H. pylori infection and GERD [1,17].…”

H. pylori gastriti ve mukozal özefajit arasında bir ilişki var mı?

“…On the other hand, in antrum-limited H. pylori infection leads to destruction of somatostatin secreting cells, hypergastrinemia and hyperacidity occur during the H. pylori infection. 7 So, according to these theories, we can say that the risk of GERD increases in H. pylori infection. However, the acidity and therefore the risk of GER are only reduced in atrophic gastritis.…”