a b s t r a c tMetallic glass Ta 38 Ni 62 strips, metallic W, and V 87.5 Cr 4.17 Ti 4.17 Nb 4.17 alloy were irradiated using a 500 keV He 2+ ion beam at different fluence to compare the metallic glass resistance to irradiation. Metallic glass Ta 38 Ni 62 remained amorphous at different He 2+ irradiation fluence. Transmission electron microscopy analysis revealed the presence of helium bubbles at the end of the range of helium ions in the metallic glass. No significant damage resulted in the metallic glass surface, and the root mean square roughness increased nonlinearly with the increase in fluence. At 1 × 10 18 ions/cm 2 , metallic W appeared in larger sunken areas on the surface and V 87.5 Cr 4.17 Ti 4.17 Nb 4.17 alloy experienced multi-layer flaking. The metallic glass Ta 38 Ni 62 resistance to He 2+ ion beam irradiation was better than that of metallic W, and that of the V 87.5 Cr 4.17 Ti 4.17 Nb 4.17 alloy was the poorest.